Protein Alignment CG3842 and HSD11B2

DIOPT Version :10

• Sequence 1: NP_572316.1
• Gene: CG3842 / 31576
• FlyBaseID: FBgn0029866
• Length: 406
• Species: Drosophila melanogaster
• Sequence 2: NP_000187.3
• Gene: HSD11B2 / 3291
• HGNCID: 5209
• Length: 405
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 80/300 - (26%)
• Similarity: 108/300 - (36%)
• Gaps: 76/300 - (25%)

  Fly    45 LIVLGILLFM-WLLRKCIQGPAYRKANRIDG-----------------KVVIVTGCNTGIGKETV 91
            |..|.:|..: ||.::.:..||........|                 :.|::|||::|.||||.
Human    35 LAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETA 99

  Fly    92 LELAKRGARV---YMACRDPG-----RCEAARLDIMDRSRNQQLFNRTLDLGSLQSVRNFVERFK 148
            .:|...|..|   .:....||     .|.:.||.::.           :||.....:...:|..|
Human   100 KKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQ-----------MDLTKPGDISRVLEFTK 153

  Fly   149 AEESRLDI--LINNAG---VMACPRTLTADGFEQQFGVNHLGHFLLTNLLLDRLKHSSPSRIVVV 208
            |..:...:  |:||||   |:|.........|.....||..|...||..||..|: ||..|||.|
Human   154 AHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLR-SSRGRIVTV 217

  Fly   209 SSAAHLFGRINREDLMSEKNYSKFFGAYSQSKLANILFTLKLSTILKDTGVTVNCCHPGVVRTEI 273
            .|.|            .:..| ...|||..||.|..|.....|..|...||.|:...||..:||.
Human   218 GSPA------------GDMPY-PCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTES 269

  Fly   274 NRHFSGPGWMKTALQKGSLYFFKTPKAGAQTQLRLALDPQ 313
            .|:..  .|.|                  :.||.||..||
Human   270 VRNVG--QWEK------------------RKQLLLANLPQ 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3842	NP_572316.1	Rossmann-fold NAD(P)(+)-binding proteins	74..347	CDD:473865	72/269 (27%)
HSD11B2	NP_000187.3	type2_17beta_HSD-like_SDR_c	83..363	CDD:187665	71/251 (28%)
		Essential for protein stability	335..339
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..405