Protein Alignment Rpt4 and YME1L1

DIOPT Version :10

• Sequence 1: NP_572308.3
• Gene: Rpt4 / 31567
• FlyBaseID: FBgn0028685
• Length: 397
• Species: Drosophila melanogaster
• Sequence 2: NP_647473.1
• Gene: YME1L1 / 10730
• HGNCID: 12843
• Length: 773
• Species: Homo sapiens
• Alignment Length: 413
• Identity: 129/413 - (31%)
• Similarity: 199/413 - (48%)
• Gaps: 74/413 - (17%)

  Fly    13 RVKALSEYRKKLLEHKEIEGR------LKEKREEIKDLTKLYDKSENDLKALQSV-------GQI 64
            |.:.|....::|.|.:.|...      |:::..:::.|.||. |::|..:|.|..       |.:
Human   214 RTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLM-KTKNIPEAHQDAFKTGFAEGFL 277

  Fly    65 VGEVLKQLTEDKFIVKATNGPRYVVGCRRQLDKAKLKSGTRVALDMTTL-----------TIMRY 118
            ..:.|.|.|.|..              ||          ||:.|.:..|           ..:|:
Human   278 KAQALTQKTNDSL--------------RR----------TRLILFVLLLFGIYGLLKNPFLSVRF 318

  Fly   119 -----LPREVDPLVYNMSHEDPGDVTYSAIGGLTDQIRELREVIELPLLNPELFLRVGITPPKGC 178
                 |...|||:...       :||:..:.|:.:..:||:||:|. |.||:.|..:|...|||.
Human   319 RTTTGLDSAVDPVQMK-------NVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGI 375

  Fly   179 LLYGPPGTGKTLLARAVASQLDANFLKVVSSAIVDKYIGESARLIREMFNYARDHQPCIIFMDEI 243
            ||.|||||||||||||||.:.|..|.....|...:.::|..|..||.:|..|:.:.||:||:||:
Human   376 LLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDEL 440

  Fly   244 DAIGGRRFSEGTSADREIQRTLMELLNQMDGFDSLGQVKMIMATNRPDTLDPALLRPGRLDRKIE 308
            |::||:|..  :......::|:.:||.:||||.....|.:|.|||.|:.||.||:||||.|.::.
Human   441 DSVGGKRIE--SPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVT 503

  Fly   309 IPLPNEQARLEILKIHALKIAKHGEIDYEAIVKLSDNFNGADLRNVCTEAGLFAIRAEREYVIQE 373
            :|.|:.:.|.||||.:..||.....:|.|.|.:.:..|:||:|.|:..:|.|.|....:|.|..:
Human   504 VPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMK 568

  Fly   374 DFMKAVRKV----------SDNK 386
            :...:..|:          .|||
Human   569 ELEFSKDKILMGPERRSVEIDNK 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpt4	NP_572308.3	PRK03992	13..387	CDD:179699	129/413 (31%)
YME1L1	NP_647473.1	HflB	<332..767	CDD:440233	100/270 (37%)