DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3781 and JOSD1

DIOPT Version :9

Sequence 1:	NP_572303.4	Gene:	CG3781 / 31560	FlyBaseID:	FBgn0029853	Length:	221	Species:	Drosophila melanogaster
Sequence 2:	NP_001347164.1	Gene:	JOSD1 / 9929	HGNCID:	28953	Length:	202	Species:	Homo sapiens

Alignment Length:	181	Identity:	80/181 - (44%)
Similarity:	116/181 - (64%)	Gaps:	7/181 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PHGIYHERQTRHLCGLHALNNLFQGPDMFSKSELDDYCTTLTPRNWLNPH-RSWIGWGNYDVNVI 99
            |..||||:|.|.||.||||||:||..:.|::..|.:....|:|...:.|| :|.:|.||||||||
Human    23 PPQIYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVI 87

  Fly   100 MYALQQRNCEAVWFDRRRDPHCLNLSVIFGFILNVPAQMSLGYYIPLPFHMRHWLALRRLNGSYY 164
            |.|||.:..||||:|:|||...:.|:.:.|||:|:|:.:..| .:.||...:||:.:|.:.|:||
Human    88 MAALQTKGYEAVWWDKRRDVGVIALTNVMGFIMNLPSSLCWG-PLKLPLKRQHWICVREVGGAYY 151

  Fly   165 NLDSKLREPKCLGTEQQFLEFLATQLQ-MDHELFLVLDEETDCKDKSQQRW 214
            ||||||:.|:.:|.|.:..:||...|: .:.||.||:.||.:    :.|.|
Human   152 NLDSKLKMPEWIGGESELRKFLKHHLRGKNCELLLVVPEEVE----AHQSW 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3781	NP_572303.4	Josephin	44..184	CDD:280299	64/140 (46%)
JOSD1	NP_001347164.1	Josephin	31..173	CDD:396601	64/142 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154182
Domainoid	1	1.000	145	1.000	Domainoid score	I4586
eggNOG	1	0.900	-	-		E1_KOG2934
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I4249
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59780
OrthoDB	1	1.010	-	-		D1482722at2759
OrthoFinder	1	1.000	-	-		FOG0002676
OrthoInspector	1	1.000	-	-		otm40633
orthoMCL	1	0.900	-	-		OOG6_104335
Panther	1	1.100	-	-	LDO	PTHR13291
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8572
SonicParanoid	1	1.000	-	-		X1788
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800