Protein Alignment dtn and Tmem132a

DIOPT Version :10

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_001365847.1
• Gene: Tmem132a / 98170
• MGIID: 2147810
• Length: 1019
• Species: Mus musculus
• Alignment Length: 1159
• Identity: 290/1159 - (25%)
• Similarity: 466/1159 - (40%)
• Gaps: 264/1159 - (22%)

  Fly     4 YCLIIALQLSLAYSVEVHFEAPDSGFFLKHARQPPVTPEIANVQTSSAVPP----LRQRSSYDSV 64
            :||::||.|.:. .|..:.:..|. .:|..|.:....||...||.....||    |..||
Mouse    17 FCLLVALALEVV-RVSSNHDTLDP-IYLPVALELLDAPEHFRVQQVGHYPPANSSLASRS----- 74

  Fly    65 LSLDRFTVVE---TTQPVSIRASYGPFSTKQTVPARYIVPDTMDSQSGDYMNNATLLELQQPNMH 126
               :.|.:::   ..||: :||||.||:|:|.||.|...|.                  ::| :.
Mouse    75 ---ETFLLMQPWPRAQPL-LRASYPPFATQQVVPPRVTEPH------------------RRP-VP 116

  Fly   127 LDISAHLVRSSVSQDAPVLRVLFH-AGAD--PG-GHLQRQKVCVLLHVAMGSEQPLKGRCMPEGE 187
            .|:.|..|.::|:...|..||||| .|.|  || |.|.    |..||....:....:. |..:..
Mouse   117 WDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGPGSLP----CARLHATHPAGTAHRA-CRFQPS 176

  Fly   188 DGVCVAEVVVPLGWWPQLPAPTQDGSGQAPPKVPQRYAQVSYSVFEPPLRNPEQC------EPKV 246
            .|.||.|:..|..|:.| .|.|:              |:::|:: ||....|..|      ||:.
Mouse   177 LGACVVELQFPSHWFSQ-SATTR--------------AELAYTL-EPAGEGPGGCGLGTEEEPRE 225

  Fly   247 QIQPLTTFAQVPLLAARTP-YRMLRADDAVTFLLPQHPLYPLSRLHVPVFL--HQYPDQRVAAFT 308
            |..|:   ..|.|.....| |:.:..|:|||...|..|:.| .:|.....|  |.:   ..:..|
Mouse   226 QALPV---GGVELHPEDPPQYQEVPLDEAVTLRAPDVPMRP-GQLFTATLLLRHNF---TASLLT 283

  Fly   309 VRARVKAGLKILGA-TASTDQWSVSVEK-ENPKHTTARVTAFR-----KEAESSLESGGNLTSEV 366
            :|.:||.||:::.| .|....|:..::: :..||.|:.:|..|     .::.|.||     .||
Mouse   284 LRIKVKKGLQVIAARPAQPTLWTAKLDRFKGSKHHTSLITCHRAGPAGPDSSSPLE-----LSE- 342

  Fly   367 FEVFSWLLEVAEDTNDIVDGGKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQA 431
               |.|:....|  |....|..:...||...:.|     |:  .|:..|.:::.::.:::.||:|
Mouse   343 ---FLWVDFAVE--NSTGGGVAVTRPVTWQLEYP-----GQ--APEAEKDKMVWEILVSERDIRA 395

  Fly   432 VLPMAKIWEVMNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVD 496
            ::|:||..|::|||.|||......:::..|...|.:.:||....|.:.:..|::||.:|.:|:|.
Mouse   396 LIPLAKAEELVNTAPLTGVPQRIPVRLVTVDSGGALEEVTEHIGCESANTQVLQVSEACDAVFVA 460

  Fly   497 GSEQRGSSNASVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKV--TDDNHYLHNKQS 559
            |.|.||:....|...:.......|..||.|..||.:.::|..|.||:||:|  :.:........:
Mouse   461 GQESRGAKGVRVDFWWRRLRASLKLTVWAPLLPLRIELTDTTLEQIRGWRVPGSAEGQLEPETAA 525

  Fly   560 RRRKKRSYVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNSG-RTSYFISRRTGLR 623
            ...::||     .|             ||.:||::.|.....|.|...:.| |.::.:.....|.
Mouse   526 EEVERRS-----RG-------------CRLQYQRAGVRFLVPFAAHPLDGGRRLTHLLGPDWLLD 572

  Fly   624 VTDLVQPLLRVADPKIASLK-GRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLIV 687
            |:.||.....|.||:||||: ||||.|:..|.|.::|.||::..::|.:.:.|..|||::..|.|
Mouse   573 VSHLVAAHAHVQDPRIASLEGGRILVGREPGVTSIEVRSPLSDAILGEQALAVTDDKVSVLDLRV 637

  Fly   688 RVISGLQLTISPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLLV 752
            :.:.|:.|::|...:......|.......|.|..||..|.:.|.|:|.:..|.......|..|.|
Mouse   638 QPVMGISLSLSRGMSHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTLAPAELYDRNDLGLSV 702

  Fly   753 ESLDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRRGTLSSSKQNKSNAAPLASA 817
            .:.:...|..|....:....|::.....|..|.|.|...|.||:.|           :..||||.
Mouse   703 SAEEPSAVLPAEEQGAQLGVVVSGVGAEGLPLHVALHPPEPCRRGR-----------HRVPLASG 756

  Fly   818 LASIEVDFNNVDIVSKQEAIQNDGTVGRERKNYRQTGDLADIIVGIPLRDSSQLYEPTVQARQHR 882
            .|.:.:.    .:.:...|:.:.                       |:| :|...|.||:.::..
Mouse   757 TAWLGLP----PLPTPVPALPSS-----------------------PVR-TSPFTEATVEGKRQI 793

  Fly   883 GSIQAVHKGHHGK------------------------GLAGTGTMTTMELGMYVLLTAFCFAIIV 923
            ......|.|..||                        .:.....:|.:|||||.||..||.||::
Mouse   794 AGDMGGHVGIRGKFERAEEEAGKEENEAKEEEEDEEEMVPAPQRVTDLELGMYALLGIFCLAILI 858

  Fly   924 FVISCVVYASKF-RPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDWVWLGRSTIDRQ 987
            |:::.||:..:: |....:|..||.|                      ...|:|||||
Mouse   859 FLVNGVVFVLRYQRKEPPDSATDPAS----------------------PQPHNWVWLG------- 894

  Fly   988 SIVAETNTHLNPRDSRMRITSNPIVNYDNGRRVSSFDQQPKLQ-------------THIVPASNL 1039
                 ||.....|......:|.|                ||.:             :.:.|:::.
Mouse   895 -----TNQEELSRQLDRCSSSGP----------------PKGEGGCPCESGAGGDASTVAPSASE 938

  Fly  1040 NKQHADHYLANER---KDNALDY-----KPPV-PPHRNVGARACLPVQPVLGTG 1084
            :...:...||.:.   :...:::     .||. ||...|||.|   ||.:|..|
Mouse   939 SPAGSSSTLARKEAGGRRKRVEFVTFAPAPPTQPPEEPVGAPA---VQSILVAG 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:464813	47/162 (29%)
		TMEM132	440..796	CDD:465003	101/359 (28%)
		TMEM132D_C	881..982	CDD:464814	30/125 (24%)
Tmem132a	NP_001365847.1	TMEM132D_N	44..164	CDD:464813	45/151 (30%)
		TMEM132	404..746	CDD:465003	101/359 (28%)
		Binds to HSPA5/GRP78. /evidence=ECO:0000250	607..912		83/377 (22%)
		Confers cellular localization similar to full-length form. /evidence=ECO:0000250	667..1019		87/415 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..834		0/25 (0%)
		TMEM132D_C	<831..896	CDD:464814	26/98 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	901..957		8/71 (11%)