Protein Alignment dtn and TMEM132A

DIOPT Version :10

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_016873440.1
• Gene: TMEM132A / 54972
• HGNCID: 31092
• Length: 1037
• Species: Homo sapiens
• Alignment Length: 1048
• Identity: 268/1048 - (25%)
• Similarity: 423/1048 - (40%)
• Gaps: 224/1048 - (21%)

  Fly     8 IALQLSLAYSVEVHFEAPDSGFFLKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTV 72
            :.:..|.|.||:.. :||....:|..|.:....||...||.....||.....|..|    :.|.:
Human    37 VIISPSYASSVDCG-QAPLDPVYLPAALELLDAPEHFRVQQVGHYPPANSSLSSRS----ETFLL 96

  Fly    73 VE---TTQPVSIRASYGPFSTKQTVPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLDISAHLV 134
            ::   ..||: :||||.||:|:|.||.|...|.                  |:| :..|:.|..|
Human    97 LQPWPRAQPL-LRASYPPFATQQVVPPRVTEPH------------------QRP-VPWDVRAVSV 141

  Fly   135 RSSVSQDAPVLRVLFH-AGAD--PG-GHLQRQKVCVLLHVA--MGSEQPLKGRCMPEGEDGVCVA 193
            .::|:...|..||||| .|.|  || |.|.    |..||..  .|:...   .|..:...|.||.
Human   142 EAAVTPAEPYARVLFHLKGQDWPPGSGSLP----CARLHATHPAGTAHQ---ACRFQPSLGACVV 199

  Fly   194 EVVVPLGWWPQLPAPTQDGSGQAPPKVPQRYAQVSYSVFEPPLRNPEQC------EPKVQIQPLT 252
            |:.:|..|:.|.....               |:::|:: ||....|..|      :|..|..|:
Human   200 ELELPSHWFSQASTTR---------------AELAYTL-EPAAEGPGGCGSGEENDPGEQALPV- 247

  Fly   253 TFAQVPLLAARTP-YRMLRADDAVTFLLPQHPLYPLSRLHVPVFL-HQYPDQRVAAFTVRARVKA 315
              ..|.|..|..| |:.:..|:|||..:|..|:.|.......:.| |.:   ..:..|:|.:||.
Human   248 --GGVELRPADPPQYQEVPLDEAVTLRVPDMPVRPGQLFSATLLLRHNF---TASLLTLRIKVKK 307

  Fly   316 GLKILGA-TASTDQWSVSVEK-ENPKHTTARVTAFR-----KEAESSLESGGNLTSEVFEVFSWL 373
            ||.:..| .|....|:..::: :..:|.|..:|..|     .::.|.||     .||    |.|:
Human   308 GLHVTAARPAQPTLWTAKLDRFKGSRHHTTLITCHRAGLTEPDSSSPLE-----LSE----FLWV 363

  Fly   374 LEVAEDTNDIVDGGKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKI 438
            ..|.|  |....|..:...||...:.|     |:  .|:..|.:::.::.:::.||:|::|:||.
Human   364 DFVVE--NSTGGGVAVTRPVTWQLEYP-----GQ--APEAEKDKMVWEILVSERDIRALIPLAKA 419

  Fly   439 WEVMNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGS 503
            .|::|||.|||......:::..|...|.:.:||....|.:.:..|::||.:|.:|:|.|.|.||:
Human   420 EELVNTAPLTGVPQHVPVRLVTVDGGGALVEVTEHVGCESANTQVLQVSEACDAVFVAGKESRGA 484

  Fly   504 SNASVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKV-------TDDNHYLHNKQSRR 561
            ....|...:.......:..||.|..||.:.::|..|.|::||:|       .:......::..||
Human   485 RGVRVDFWWRRLRASLRLTVWAPLLPLRIELTDTTLEQVRGWRVPGPAEGPAEPAAEASDEAERR 549

  Fly   562 RKKRSYVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNSG-RTSYFISRRTGLRVT 625
            .:.                      |..:||::.|...|.|.|...:.| |.::.:.....|.|:
Human   550 ARG----------------------CHLQYQRAGVRFLAPFAAHPLDGGRRLTHLLGPDWLLDVS 592

  Fly   626 DLVQPLLRVADPKIASLK-GRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLIVRV 689
            .||.|..||.|.::|||: ||::.|:..|.|.::|.||::..::|.:.:.|..|||::.:|.|:.
Human   593 HLVAPHARVLDSRVASLEGGRVVVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQP 657

  Fly   690 ISGLQLTISPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLLVES 754
            :.|:.||:|..........|.......|.|..||..|.:.|.|:|.:..|.......|..|.|.:
Human   658 VMGISLTLSRGTAHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTVAPAELYDRRDLGLSVSA 722

  Fly   755 LDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRR-------GTLSSSKQNKSNAA 812
            .:...:..|....:....|::.....|..|.|.|...|.||:.|       ||........|..|
Human   723 EEPGAILPAEEQGAQLGVVVSGAGAEGLPLHVALHPPEPCRRGRHRVPLASGTAWLGLPPASTPA 787

  Fly   813 P-LASALA----SIEVDF-----------NNVDIVSK----QEAIQNDGTVGRERKNYRQTGDLA 857
            | |.|:.|    :.|...           .|..:..|    :|..:.:.|..||.:...:
Human   788 PALPSSPAWSPPATEATMGGKRQVAGSVGGNTGVRGKFERAEEEARKEETEAREEEEEEE----- 847

  Fly   858 DIIVGIPLRDSSQLYEPTVQARQHRGSIQAVHKGHHGKGLAGTGTMTTMELGMYVLLTAFCFAII 922
                           |..|.|.||                     :|.:|||||.||..||.||.
Human   848 ---------------EEMVPAPQH---------------------VTELELGMYALLGVFCVAIF 876

  Fly   923 VFVISCVVYASKF-RPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDWVWLGRS---- 982
            :|:::.||:..:: |....:|..||.|                      ...|:|||||..
Human   877 IFLVNGVVFVLRYQRKEPPDSATDPTS----------------------PQPHNWVWLGTDQEEL 919

  Fly   983 --TIDRQS 988
              .:||||
Human   920 SRQLDRQS 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:464813	48/158 (30%)
		TMEM132	440..796	CDD:465003	96/364 (26%)
		TMEM132D_C	881..982	CDD:464814	27/101 (27%)
TMEM132A	XP_016873440.1	TMEM132D_N	61..181	CDD:464813	45/147 (31%)
		TMEM132	421..764	CDD:465003	96/364 (26%)
		TMEM132D_C	<850..915	CDD:464814	30/107 (28%)