Protein Alignment dtn and Tmem132c

DIOPT Version :10

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_780641.2
• Gene: Tmem132c / 208213
• MGIID: 2443061
• Length: 1107
• Species: Mus musculus
• Alignment Length: 1200
• Identity: 309/1200 - (25%)
• Similarity: 494/1200 - (41%)
• Gaps: 261/1200 - (21%)

  Fly    18 VEVHFEAPDSGFFLKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIR 82
            |..|....::.||||.|     .|:           |||..|....|   :.|.:.:..||..:.
Mouse    58 VSFHVLRAETAFFLKEA-----NPD-----------PLRNASLQSRV---ESFFIYKAQQPPVLN 103

  Fly    83 ASYGPFSTKQTVPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLD----ISAHLVRSSVSQDAP 143
            .||||:|.::.:|.             |.|.|...|   .|.....    :.|::::..|....|
Mouse   104 VSYGPYSAEKVIPL-------------DLMLNPNFL---GPTSKFPFDWRLKAYILQEKVYLSHP 152

  Fly   144 VLRVLFH-AGADPGGHLQRQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPA 207
            .::|||| .|.|...|...:..|:.: .|....:.::|.|...|..|:|||::.:..||:    :
Mouse   153 KVQVLFHIVGRDWDDHRDEKLPCLRV-FAFRDSREVRGSCRLGGPLGLCVAQLEMLPGWF----S 212

  Fly   208 PTQDGSG-QAPPKVPQRYAQVSYSVFEP----------PLRNPEQCEP-----KVQIQPLTTFAQ 256
            |....|| :.|.:.|:......|...:|          ..|......|     :.:...|.....
Mouse   213 PPAVVSGRRRPAERPEGSPVELYYAVQPGDERGDCTGGDTRKDNAIRPGKDGQEGRTSHLQKIGT 277

  Fly   257 VPLLAAR--TPYRMLRADDAVTFLLPQHPLYPLSRLHVPVFLHQYPDQRVAAFTVRARVKAGLKI 319
            :.|..|:  |....||.|..|...||..|:.....:...|.:..  :..|..|.:||:||.|:.|
Mouse   278 ISLYRAQDSTQLSELRLDGNVVIWLPSQPVKQGDIVTASVTIAN--NSTVDHFILRAKVKKGVNI 340

  Fly   320 LGA-TASTDQWSVSVEKEN-PKHTTARVTAFRKEAESSLESGGNLTSEV----FEVFSWLLEVAE 378
            |.. |:...||.|..|..| .||||..| |.::....:.....||.|||    ||:.|:
Mouse   341 LTVQTSEPRQWDVRQEVGNGGKHTTTSV-ACQRLGPGARNRSSNLFSEVMQMNFEIASF------ 398

  Fly   379 DTNDIVDGGKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEVMN 443
              :.:.....|.|.|.:    |: |.:.::.         ::::.|::.|:.|::|:|...|::|
Mouse   399 --SSLSGTQPITWQVEY----PR-KGATDIA---------VSEIFISQKDLVAIVPLAMDTELLN 447

  Fly   444 TAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNASV 508
            ||:|||:.||..::|..|.:...:.|::....|.|.||:|||||..|..|:|:|.|.:|..::.|
Mouse   448 TAILTGKTVAMPVRVVSVEENSTLRDISELVECKATDENVIKVSDHCDYVFVNGKEIKGKMDSVV 512

  Fly   509 IVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKVTDDNHYLHNKQSRRRKKRSYVWGQHG 573
            ...|..........||:|..||::.:||..|||:|||:|.    .:.:|:..|..:......|.|
Mouse   513 NFTYQHLSAPLHVTVWVPRLPLQIEVSDTELSQVKGWRVP----IVASKRPTRDSEEEEEEEQKG 573

  Fly   574 TNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNS-GRTSYFISRRTGLRVTDLVQPLLRVADP 637
            ..           |..::|.:.|.|..:|::..... |:.|:.:|......:|.||...:::..|
Mouse   574 RG-----------CTLQFQHATVRVLTQFVSEGAGPWGQLSHLLSPDWQFDITHLVADFMKLESP 627

  Fly   638 KIASLK-GRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLIVRVISGLQLTISPDN 701
            .||:|: .|:|.|:.:|.|.:|||||::..::..|.:.|..|||:::.|.|:|::||.:|:.|.:
Mouse   628 HIATLQDSRVLVGREVGMTTIQVLSPLSDSILAEKTVTVLDDKVSVTDLAVQVVAGLSVTLHPIS 692

  Fly   702 TIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLLVESLDTEVVAFAPML 766
            .......|.......|.|..:|.::...|:|:|||.|||.....:|:.|...|||..||:....|
Mouse   693 ENNKATSAVAMAEELLRAPKKEAIISTWLQFSDGSVTPLDIYDSKDFSLTAISLDEAVVSIPQPL 757

  Fly   767 ASHHPRVIAVGEGNGNLLRVTLLLSEECRQRRGTLSSSKQNKSNAAPLASALASIEVDFNNVDIV 831
            :...|.|:|.|||.|.||||.:.::|.|           |.....:.||..:..:.|.|...|..
Mouse   758 SPWWPTVVAEGEGQGPLLRVDMSIAEAC-----------QKSKRKSVLAVGIGHVGVKFGWDDAD 811

  Fly   832 SKQ------EAIQNDGTVGRER--------------KNY---RQTG---------DLADIIVG-I 863
            |.|      |.|:|..:..|::              .|:   |:.|         .|.|..|| .
Mouse   812 SSQTGEKDEEEIKNHASDRRQKIQDLERPGQDELYHGNFPGDREEGALSATTTTKSLLDNNVGKS 876

  Fly   864 PLRDSSQLYE--------------PTVQAR---QHRGSIQAVHKGHHGKGLAGTGTMTTMELGMY 911
            ..||.::|:.              |..:.|   :..|.:|..|      ||      :.:|:|||
Mouse   877 GRRDGARLHSIPIDFTNFPAHVDLPKAKTRGTLEENGLMQTAH------GL------SDLEIGMY 929

  Fly   912 VLLTAFCFAIIVFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDW 976
            .||..||.||:||:|:|..:|.|:|...:     ||..                 :.|.|::|||
Mouse   930 ALLGVFCLAILVFLINCATFAFKYRHKQV-----PLEG-----------------QASMTHSHDW 972

  Fly   977 VWLGR-------------------STIDRQSIVAETNTHLNPRDSRMRITSNPIVN--YDNGRRV 1020
            ||||.                   :.|||.....|.|.||.......:.|.:.:..  ...||:.
Mouse   973 VWLGNEAELLENIGDLSPPQDEHTTIIDRGLGGCEENNHLLLNGGSQKPTQSQVHRPPGSGGRQT 1037

  Fly  1021 SSFDQQPKLQTHIVPASNLNKQHADHYLANERKDNALDYKPPVPPHRNVGARACLPVQPVL-GTG 1084
                ::|:.:....|.|.:.|.....:              .:||.     .:|..|..:| |..
Mouse  1038 ----REPRQEPANSPTSKMKKVKFATF--------------TIPPE-----ESCPTVNSILSGED 1079

  Fly  1085 SVK-------DAAPNKRHSQLYRREHLQNS 1107
            .:|       ..||.:..:.|   |..|:|
Mouse  1080 DIKWVCQDLDVGAPKELRTYL---EKFQDS 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:464813	38/156 (24%)
		TMEM132	440..796	CDD:465003	117/357 (33%)
		TMEM132D_C	881..982	CDD:464814	33/119 (28%)
Tmem132c	NP_780641.2	TMEM132D_N	58..185	CDD:464813	39/162 (24%)
		TMEM132	444..787	CDD:465003	117/368 (32%)
		TMEM132D_C	892..978	CDD:464814	35/119 (29%)