Protein Alignment dtn and Tmem132b

DIOPT Version :10

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_001177281.1
• Gene: Tmem132b / 208151
• MGIID: 3609245
• Length: 1078
• Species: Mus musculus
• Alignment Length: 1163
• Identity: 289/1163 - (24%)
• Similarity: 488/1163 - (41%)
• Gaps: 308/1163 - (26%)

  Fly    21 HFEAPDSGFFLKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRASY 85
            |....:..||||.|.|..:  ..|::|..||...:.:..|                 |.:|.|||
Mouse    46 HVTDAEEAFFLKEANQDLM--RNASLQARSATLFIHRAQS-----------------PPAINASY 91

  Fly    86 GPFSTKQTVPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLDISAHLVRSSVSQDAPVLRVLFH 150
            ||||.::|||..:::   |.:..|:         :::...:..:.:|::.||:..:.|.::.||:
Mouse    92 GPFSVEKTVPWDFLL---MPTPFGN---------MERFPFNWRLKSHILDSSIFSNRPKVQTLFY 144

  Fly   151 AGA------DPGGHLQRQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWW------- 202
            ...      |||..|.    ||.: .|....:.:...|..:|..|:||||:.:...|:
Mouse   145 VTGMGWDENDPGDDLP----CVKM-FAFPEAREVAASCRLQGAPGLCVAELELLPEWFSSGLDLE 204

  Fly   203 PQ--LPA--------------PTQDGSGQAPPKVPQRYAQVSYSVFEPPLRNPEQCEPKVQIQPL 251
            ||  :||              |..: :||.|.:...::....:|         ||.||:
Mouse   205 PQEEIPALLGGTAMELYFALYPANE-AGQCPLEEEGKWENNIHS---------EQEEPQ------ 253

  Fly   252 TTFAQVPLLAAR--------------TPYRMLRADDAVTFLLPQHPLYPLSRLHVPVFLHQYPDQ 302
                  |:|.||              ..:.::..||.|...:   ||..:.......||......
Mouse   254 ------PVLPARERIGSVVVYPTQDDLRWSLVTLDDNVALSI---PLNLIREGDTATFLVSLTSG 309

  Fly   303 RVA-AFTVRARVKAGLKILGATAS-TDQWSVSVE-KENPKHTTARVTAFRKEAESSLESGGNLTS 364
            .:| .||:|.:..||:||.....| .|||:|..| :::...|||.::......::...:.|:
Mouse   310 SLAEKFTLRIKAAAGVKITAVRVSHEDQWAVQEEIEQDGTQTTAVLSCMGHHPDTQSRANGS--- 371

  Fly   365 EVFEVFSWLLEV---AEDTNDIVDGGKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINK 426
                 |..:|:|   .::::.:....:|.|.|             |..:.|...:..::::.|::
Mouse   372 -----FYEILQVDFGVDNSSSLAGAQQITWQV-------------EYPVEDSMSELFVSEIFISQ 418

  Fly   427 DDIQAVLPMAKIWEVMNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCS 491
            .....::|:....|::|||:|||:.|:..:||..|.:.|.|.||.....|.:.||.|:|||::|.
Mouse   419 TTFVGIVPLTMDTEILNTAILTGKPVSVPVKVVGVQEDGSVVDVLESVECRSADEDVVKVSNTCD 483

  Fly   492 SVYVDGSEQRGSSNASVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKV--------- 547
            |::|:|.|.:......|...:..:....:..||:|..||::.|||..|||||||::
Mouse   484 SIFVNGKEMKSKVGTIVNFTHQHFTSQVEITVWVPRLPLQIEISDTELSQIKGWRIPVASNRRPT 548

  Fly   548 --TDDNHYLHNKQSRRRKKRSYVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNSG 610
              :||      ::...:|.|.                    |..:||.:.|.|..:|::...:.|
Mouse   549 RESDD------EEDEEKKGRG--------------------CTLQYQHALVRVLTQFVSESPDLG 587

  Fly   611 RTSYFISRRTGLRVTDLVQPLLRVADPKIASLK-GRILQGKSMGRTDVQVLSPITGRVIGTKEIR 674
            :.:|.:.......:|:||...::|.:||||.|: ||||.|:..|.|.||||||::..::..|.:.
Mouse   588 QLTYMLGPDWQFDITNLVTEFVKVEEPKIAQLQNGRILAGREPGITTVQVLSPLSDSILAEKTVI 652

  Fly   675 VGSDKVNLSKLIVRVISGLQLTISPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTP 739
            |..|:|.:::|.|::::||.|::.|....:...::..:....|.|..||.::...:.|:||:.||
Mouse   653 VLDDRVTITELGVQLVAGLSLSLQPHRADKRAIVSTVAAQDVLQAPQQEAIVSSWILFSDGAVTP 717

  Fly   740 LRDIAVEDYFLLVESLDTEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECR--QRRGTLS 802
            |....::|:.:.|.|||..||:..|.|.:..|.|:|.|||.|.|:::.:.:||.|:  :|:.||:
Mouse   718 LDIYDLKDFSVTVSSLDEMVVSVQPNLQTRWPIVVAEGEGQGPLIKLEMSISESCQKNKRKSTLA 782

  Fly   803 SSKQN-KSNAAP-------LASALASIEVDF-----NNVDIVSKQEA-----IQNDGTVGRERKN 849
            ..|.| |....|       .::.:..|..::     |:::....||.     .|:...||.|.:.
Mouse   783 VGKGNVKVRFEPGMHEQQGGSNDIGGINREYKGHLSNSIEREGSQERAAQEWFQHGTPVGHEDRT 847

  Fly   850 YRQT-------GDL----ADIIVGIP----LRDSSQLYEPTVQARQHRGSIQAVHKGHHGKGLAG 899
            .:.|       |.|    ||.....|    |.:||           :.|.:....:|
Mouse   848 NKSTTPQSPMGGKLLKAGADAFTSFPTQGKLPESS-----------NPGDLTMTSRG-------- 893

  Fly   900 TGTMTTMELGMYVLLTAFCFAIIVFVISCVVYASKFRP---AMIESGLDPLSAGKSNGSGGSGGF 961
               :|.:|:|||.||..||.||:||:|:||.:|.|:|.   |:.|.|..|
Mouse   894 ---LTDLEIGMYALLCVFCLAILVFLINCVAFAWKYRHKRFAVSEQGNIP--------------- 940

  Fly   962 RDVRLKESTTNAHDWVWLGR-------------------STIDRQSIVAETNTHLN--------- 998
                      ::|||||||.                   :.|||.....|.|..||
Mouse   941 ----------HSHDWVWLGNEVELLENPVDITLPSEECTTMIDRGLQFEERNFLLNGSSQKTFHS 995

  Fly   999 -----------------------PRDSRMRITS-NPIVNYDNGRRVSS--FDQQPKLQ 1030
                                   |:..|::.|| ..|:..|.|...:|  ||....::
Mouse   996 QLLRPPDYVYEKELKNEPMGSSGPKRKRVKFTSYTTILPEDGGPYTNSILFDSDDSIK 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:464813	38/154 (25%)
		TMEM132	440..796	CDD:465003	117/369 (32%)
		TMEM132D_C	881..982	CDD:464814	32/122 (26%)
Tmem132b	NP_001177281.1	TMEM132D_N	45..171	CDD:464813	39/160 (24%)
		TMEM132	432..774	CDD:465003	117/367 (32%)
		TMEM132D_C	870..951	CDD:464814	36/127 (28%)