Protein Alignment dtn and dtn

DIOPT Version :10

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_061506853.1
• Gene: dtn / 1278729
• VectorBaseID: AGAMI1_005187
• Length: 1464
• Species: Anopheles gambiae
• Alignment Length: 1487
• Identity: 772/1487 - (51%)
• Similarity: 976/1487 - (65%)
• Gaps: 202/1487 - (13%)

  Fly     2 MRYCLIIALQLSLAYSVEVHFEAPDSGFFLKHARQPPVTPEIANVQTSSAVPPLRQRSSY-DSVL 65
            |:..|:|.: :||.:.||||||.|||||||||:.:......:.:..||:..   :.|||. ||||
Mosquito    12 MQITLLIGI-ISLTFGVEVHFETPDSGFFLKHSPRQSALASVVSAATSNYG---KVRSSNGDSVL 72

  Fly    66 SLDRFTVVETTQPVSIRASYGPFSTKQTVPARYIVPDTMDSQ----SGDYMNNATLLEL-QQPNM 125
            |:||||||:||||||:|||||||||||||||||||||.::|.    |..:...|||:|| ||.|:
Mosquito    73 SVDRFTVVQTTQPVSVRASYGPFSTKQTVPARYIVPDVLESTHTEGSSTHNTTATLMELQQQSNL 137

  Fly   126 HLDISAHLVRSSVSQDAPVLRVLFHAGADPGGHLQRQKVCVLLHVAMGSEQPLKGRCMPEGEDGV 190
            .||||||:||::|::|:|||||||||||||||||||||:|||||.:||::.||||:|||||||||
Mosquito   138 QLDISAHVVRNTVARDSPVLRVLFHAGADPGGHLQRQKICVLLHASMGNQIPLKGKCMPEGEDGV 202

  Fly   191 CVAEVVVPLGWWPQLPAPTQDGS-GQAPPKVPQRYAQVSYSVFEPPLRNPEQCEPKVQIQPLTTF 254
            |||||::|..|||.||.|.:||. ...|||.|||..||||||||||.|:||.|||||||||||.|
Mosquito   203 CVAEVIIPSNWWPPLPPPERDGRISSTPPKSPQRIVQVSYSVFEPPARSPELCEPKVQIQPLTPF 267

  Fly   255 AQVPLLAARTPYRMLRADDAVTFLLPQHPLYPLSRLHVPVFLHQYPDQRVAAFTVRARVKAGLKI 319
            |::||:.::.||:.||||:.:|.::||.||||||:||||||||....|.:|.|.||||||||::|
Mosquito   268 AKIPLIQSQLPYKELRADNTLTMMVPQQPLYPLSKLHVPVFLHPEKGQNIAVFIVRARVKAGMRI 332

  Fly   320 LGATASTDQWSVSVEKENPKHTTARVTAFRKEAESSLESGGNLTSE------VFEVFSWLLEVAE 378
            |||.||:|:|:|||||||.|||.||||||||:.:....:||:.|.:      |.|||||||||:.
Mosquito   333 LGAVASSDEWNVSVEKENTKHTVARVTAFRKDQDPDSPTGGSRTKDVSSNEAVLEVFSWLLEVSN 397

  Fly   379 DTNDIVDGGKIVWSVTHVYDTPKDK--------DSGELVIPDDNKKRLIAKLEINKDDIQAVLPM 435
            ||.:..|||:|:|||::|.|.||.|        .....|..::.:|:::|||||.|||||||||:
Mosquito   398 DTKEYWDGGRIIWSVSYVNDGPKLKTDFTTESSSQTSTVFQEEGRKKIVAKLEILKDDIQAVLPI 462

  Fly   436 AKIWEVMNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQ 500
            ||.||:|||||||||||:|||||||||||||:||||||:||..|||||:|||||||||||||||.
Mosquito   463 AKNWELMNTAVLTGRQVSQAMKVFIVSQAGKMADVTLQTSCQTEDESVMKVSSSCSSVYVDGSEV 527

  Fly   501 RGSSNASVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKVTDDNHYLHNKQSRRRKKR 565
            |||||||::||||||.|:|:|.||||||||||.::|||||||||||:.||:..:|.|.. |||||
Mosquito   528 RGSSNASILVKYGTYAGLARFTVWMPEFPLEVSVADFRLSQIKGWKIPDDHSTVHAKPI-RRKKR 591

  Fly   566 SY----VWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNSGRTSYFISRRTGLRVTD 626
            :|    ||..|..::.|.:.:::::||||||||||||:|:|:||||:|||.||.|||||||||||
Mosquito   592 AYSNGGVWAHHADDFINGISSERSVCRARYQQSPVEVFARFVAVDQDSGRVSYLISRRTGLRVTD 656

  Fly   627 LVQPLLRVADPKIASLKGRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLIVRVIS 691
            |||.||||||||||:|:||.|||::||||||||||||.|||||.:|:|||||||.:::|:|:|:|
Mosquito   657 LVQSLLRVADPKIATLRGRTLQGRAMGRTDVQVLSPINGRVIGAREVRVGSDKVTITRLMVKVVS 721

  Fly   692 GLQLTISPDNTIENGYLAETSVTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLLVESLD 756
            ||||:||.|.:|:|||:|||:||.|||||||||||||:|||:|||:||||||:|:||||||||||
Mosquito   722 GLQLSISGDGSIDNGYIAETTVTRKLTAQYQEGLLDIELEFSDGSRTPLRDISVDDYFLLVESLD 786

  Fly   757 TEVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRRGTLSSSKQNKSNAAPLASALASI 821
            |||||||||||||||||||||||||.|||||||||||||.|:....|.:..|.:..||.|||||:
Mosquito   787 TEVVAFAPMLASHHPRVIAVGEGNGELLRVTLLLSEECRLRKNVPVSKQGMKISVGPLISALASV 851

  Fly   822 EVDFNNVDIVSKQEAIQNDGTVGRER-KNYRQTGDLADIIVGIPLRDSSQL-YEPTVQA-RQH-R 882
            .|||::.|...|.:|:||||.:||:| |:.::..||.||::||||:||:.. ..|.|.: ||| |
Mosquito   852 HVDFSSSDKNIKSDAVQNDGAIGRDRTKSGKELSDLEDILIGIPLKDSNDHDSAPVVHSTRQHLR 916

  Fly   883 GSIQAVHKGHHG-----KGLAGT---------GTMTTMELGMYVLLTAFCFAIIVFVISCVVYAS 933
            |:      |..|     .|:.|.         |..:|:|:||||:|:|||.||.:||:|||||||
Mosquito   917 GT------GGGGIISGNSGMVGVFSSNKSLVHGDASTLEIGMYVVLSAFCLAIAIFVMSCVVYAS 975

  Fly   934 KFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKES-TTNAHDWVWLGRSTIDRQSI--VAETNT 995
            |:||.:|::..:   |...:|.|.|..|...:..|| .|||||||||||:|:||.:.  :||...
Mosquito   976 KYRPVVIDANGE---ASARDGMGHSSVFDIGKGNESCATNAHDWVWLGRATVDRSNTDNIAERAP 1037

  Fly   996 HLNPRDSRMRITSNPI-VNYD----NGRRVSSFDQQPKLQ-THIVPASN---------------- 1038
            ..  :||||.|.|||: ..||    :..:::|||....:| ...||..|
Mosquito  1038 QY--KDSRMHIISNPMNSKYDEVIEHASQINSFDNPNHIQLPSSVPFQNRAVNAVSETPVALIDS 1100

  Fly  1039 ---LNKQHADHYLANERKD-----------NALDYKPPVPPHRNVGARA-C----LPVQPVLGTG 1084
               ..:.|.:..::.:...           :.::|:||||||||:|..| |    ||:.......
Mosquito  1101 GTYKKRVHHNPTISEDAPSLPQPSFATTVVDRIEYRPPVPPHRNIGVTAQCSNKQLPIDTAAQLK 1165

  Fly  1085 SVK---DAAPNKRHS-------------------QLYRREHLQNSD-------------SNANSQ 1114
            :.|   ..||....|                   |::....:|..:             ||.||.
Mosquito  1166 ATKRYHHRAPRNSSSIPFNSVDNISSNIAPSCGIQIHNASGMQKRNINHTQHQINVALFSNGNSS 1230

  Fly  1115 QSTPQPNQQLPTERPHPLAQAHPHPHPHQHQRSHSHSHNFSQEPL-IKAAHNKIKQQQQQQQQQQ 1178
            |:....:.|....|                 ||:...|:|..... |..|.|....|:.::..||
Mosquito  1231 QAKQNESTQNIIAR-----------------RSNGSPHSFENMGFSIVPASNSSYYQKDERNHQQ 1278

  Fly  1179 H---EELHNAEKLVEYTNPHQKNAFQFDSLT-----------PK-------------------RV 1210
            |   ::||.||:|||..|. ||.||:||::.           ||                   .|
Mosquito  1279 HRTSKDLHMAERLVEQPNA-QKTAFKFDTINQSKKHHQPFDRPKPSVLSDETYDQIHRGLNQQHV 1342

  Fly  1211 TKAAASSPATPSTSAVQGKAKENHSMASSTGDAANSNG----TDEIIR--------LPASAVSQE 1263
            ......||...||.....:.||.....:.:|.:.:..|    .|:.:|        ..:|..:.|
Mosquito  1343 KHTLDQSPLDLSTEFNPIQIKEECCQKTISGSSDDDGGFRLILDQSLRDDNHKREATDSSCAAFE 1407

  Fly  1264 PTTKSSRVKRATVVGNPMFSATVDESVAPGERLGLDDLDMDYEQIMHYFDNLKESNA 1320
            ..:.....|:.|||||||||.|.|..:.|.|.|||||||||||||||||||||||||
Mosquito  1408 MASSRKTKKKPTVVGNPMFSTTPDSELGPAESLGLDDLDMDYEQIMHYFDNLKESNA 1464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:464813	103/157 (66%)
		TMEM132	440..796	CDD:465003	275/359 (77%)
		TMEM132D_C	881..982	CDD:464814	50/116 (43%)
dtn	XP_061506853.1	None