Protein Alignment dtn and TMEM132D

DIOPT Version :10

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_597705.2
• Gene: TMEM132D / 121256
• HGNCID: 29411
• Length: 1099
• Species: Homo sapiens
• Alignment Length: 1153
• Identity: 291/1153 - (25%)
• Similarity: 467/1153 - (40%)
• Gaps: 284/1153 - (24%)

  Fly    18 VEVHFEAPDSGFFLKHARQPPVTPEIANVQTSSAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIR 82
            |..|....|..||||.|.|                 .:.:.||..|  .::.|.:.::.:...:.
Human    49 VTYHINNADVSFFLKEANQ-----------------DIMRNSSLQS--RVESFLIYKSRRLPVLN 94

  Fly    83 ASYGPFSTKQTVPARYIVPDTMDSQSGDYMNNATLLELQQPNMHLDISAHLVRSSVSQDAPVLRV 147
            |||||||.:|.||...::|    |....:.|..:|        :..:.||::|..|....|.::|
Human    95 ASYGPFSIEQVVPQDLMLP----SNPFGFTNKFSL--------NWKLKAHILRDKVYLSRPKVQV 147

  Fly   148 LFH-AGADPGGHLQRQKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWW--PQLPAPT 209
            ||| .|.|.......:|:..|...|....:.::|.|..:|:.|:||||:.:...|:  |.:.|..
Human   148 LFHIMGRDWDDRSAGEKLPCLRVFAFRETREVRGSCRLQGDLGLCVAELELLSSWFSPPTVVAGR 212

  Fly   210 QDGSGQAPPKVPQRYAQVSYSVFEPPLRNP---EQCEPKVQIQ-----------PLTTFAQVPLL 260
            :....| |...|   .::.|:|.....|..   |.......|:           ||.....:.|.
Human   213 RKSVDQ-PEGTP---VELYYTVHPGGERGDCVREDARRSNGIRTGHSDIDESGPPLQRIGSIFLY 273

  Fly   261 AA-RTP-YRMLRADDAVTFLLPQHPLYPLSR----LHVPVFLHQYPDQRVAAFTVRARVKAGLKI 319
            .. |.| .|.||.|::|..    |.:....|    |..||.:.:  :.....||:||:||.|:.|
Human   274 QTHRKPSLRELRLDNSVAI----HYIPKTVRKGDVLTFPVSISR--NSTEDRFTLRAKVKKGVNI 332

  Fly   320 LGATASTDQ-WSVSVEKENPKHT---TARVTAFRKEAESSLESGGNLTSEVFEVFSWLLEVAEDT 380
            :|..||:.. |.|   ||...:|   ...|...:|:|..|..|....:.||.::.   :|| |:.
Human   333 IGVRASSPSIWDV---KERTDYTGKYAPAVIVCQKKAAGSENSADGASYEVMQID---VEV-EEP 390

  Fly   381 NDIVDGGKIVWSVTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEVMNTA 445
            .|:.....:.|.|.:..:...|..              ::|:.::..|:..|:|:|...|::|||
Human   391 GDLPATQLVTWQVEYPGEITSDLG--------------VSKIYVSPKDLIGVVPLAMEAEILNTA 441

  Fly   446 VLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNASVIV 510
            :|||:.||..:||..|...|.|.::.....|.:.||.|||||..|..|:|:|.|.:|..|..|..
Human   442 ILTGKTVAVPVKVVSVEDDGTVTELLESVECRSSDEDVIKVSDRCDYVFVNGKEMKGKVNVVVNF 506

  Fly   511 KYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKGWKV--------TDDNHYLHNKQSRRRKKRSY 567
            .|.......:..||:|..||::.:||..|:|||||:|        ..|:....:.:.|.|.
Human   507 TYQHLSSPLEMTVWVPRLPLQIEVSDTELNQIKGWRVPIVSSRRPAGDSEEEEDDERRGRG---- 567

  Fly   568 VWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQN-SGRTSYFISRRTGLRVTDLVQPL 631
                               |..:||.:.|.|..:|:|.... .|..::.:.....:.:|:|:...
Human   568 -------------------CTLQYQHAMVRVLTQFVAEAAGPGGHLAHLLGSDWQVDITELINDF 613

  Fly   632 LRVADPKIASLK-GRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLIVRVISGLQL 695
            ::|.:|:||.|: |:||.|:.:|.|.:|:|||::..::..|.|.|..:||.::.|.|::::||.|
Human   614 MQVEEPRIAKLQGGQILMGQELGMTTIQILSPLSDTILAEKTITVLDEKVTITDLGVQLVTGLSL 678

  Fly   696 T--ISPDNTIENGYLAETSVTHKLTAQ-YQEGLLDIDLEFTDGSKTPLRDIAVEDYFLLVESLDT 757
            :  :||.:   |..:..|:|..:|..: .||..:...::|:|||.|||.....:|:.|:..|||.
Human   679 SLQLSPGS---NRAIFATAVAQELLQRPKQEAAISCWVQFSDGSVTPLDIYDGKDFSLMATSLDE 740

  Fly   758 EVVAFAPMLASHHPRVIAVGEGNGNLLRVTLLLSEECRQRRGTLSSSKQNKSNAAPLASALASIE 822
            :||:.........|.:.|..||.|.|::|.:::||.|           |.....:.||...|:|:
Human   741 KVVSIHQDPKFKWPIIAAETEGQGTLVKVEMVISESC-----------QKSKRKSVLAVGTANIK 794

  Fly   823 VDFNNVDIVSKQEAIQNDGTVGRERKNYRQTGDLADIIVGIPLRDSSQLYEPTVQARQHRGSIQA 887
            |.|.           |||  ......:.|.||      .|:.:.::.....|. :..|..||.:.
Human   795 VKFG-----------QND--ANPNTSDSRHTG------AGVHMENNVSDRRPK-KPSQEWGSQEG 839

  Fly   888 VHKGHHGKGL-AGTGTMT----------------------------------------------- 904
            .:.|....|| .|.||.|
Human   840 QYYGSSSMGLMEGRGTTTDRSILQKKKGQESLLDDNSHLQTIPSDLTSFPAQVDLPRSNGEMDGN 904

  Fly   905 ----------TMELGMYVLLTAFCFAIIVFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGGSG 959
                      .:|:|||.||..||.||:||:|:||.:|.|:|...:.
Human   905 DLMQASKGLSDLEIGMYALLGVFCLAILVFLINCVTFALKYRHKQVP------------------ 951

  Fly   960 GFRDVRLKESTTNAHDWVWLGRST-------------------IDR------QSIVAETNTH--- 996
             |.:   :|..:::||||.|...|                   |||      ...:..||:.
Human   952 -FEE---QEGMSHSHDWVGLSNRTELLENHINFASSQDEQITAIDRGMDFEESKYLLSTNSQKSI 1012

  Fly   997 -------LNP-----RDSRMRITSNPI-----VNYDNGRRVSSFDQQP 1027
                   |.|     :|.:....::|.     |.:.....|||.|:.|
Human  1013 NGQLFKPLGPIIIDGKDQKSEPPTSPTSKRKRVKFTTFTAVSSDDEYP 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:464813	40/152 (26%)
		TMEM132	440..796	CDD:465003	115/368 (31%)
		TMEM132D_C	881..982	CDD:464814	34/158 (22%)
TMEM132D	NP_597705.2	TMEM132D_N	49..177	CDD:464813	41/158 (26%)
		TMEM132	436..779	CDD:465003	115/379 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	797..858		18/80 (23%)
		TMEM132D_C	886..970	CDD:464814	25/105 (24%)