Protein Alignment dtn and tmem132a

DIOPT Version :10

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_002942160.1
• Gene: tmem132a / 100491977
• XenbaseID: XB-GENE-1009879
• Length: 1029
• Species: Xenopus tropicalis
• Alignment Length: 982
• Identity: 218/982 - (22%)
• Similarity: 372/982 - (37%)
• Gaps: 212/982 - (21%)

  Fly    78 PVSIRASYGP--FSTKQTVPARYIVP---DTMDSQSGDYMNNATLLELQQPNM-----HLD---- 128
            ||||.....|  |..::..|....||   :...|.|..::  .|.|..::|::     ||.
 Frog    27 PVSIEVKDVPQYFRLQRAAPGEESVPTHGNIAQSHSETFI--VTRLGSREPHVRASYQHLQVQEN 89

  Fly   129 ------------ISAHLVRSSVSQDAPVLRVLFHAGADPGGHLQRQKVCVLLHVAMGSEQPLKGR 181
                        :...:|...||...||.|:|||.....|.....|..||.:........ ::|.
 Frog    90 VPWNKLGARIRGVQGEVVGDEVSPSDPVTRILFHRSGVDGQARGAQNTCVNVRGTYDGVN-VEGS 153

  Fly   182 CMPEGEDGVCVAEVVVPLGWWPQLPAPTQDGSGQAPPKVPQRYAQVSYSVFEPPLRNPEQCEPKV 246
            |..:....|||.|::....|:.....|..              ..::|.|       .:.|:...
 Frog   154 CRIQLPLDVCVVELLFSPSWFSLSTLPLN--------------VTLTYMV-------SDDCKSMG 197

  Fly   247 QIQPLTTFAQVPLLAARTP-YRMLRADDAVTFLLPQHPLYPLSRLHVPVFLHQYPDQRVAAFTVR 310
            ::..:.  ..|.:::..|| .:.:...|:||..||...|.|.......:.|.|...|  .:|::|
 Frog   198 EVSEVA--GSVRVVSVGTPRIQQVSVGDSVTISLPDKTLLPGEVFTASINLRQNWTQ--PSFSLR 258

  Fly   311 ARVKAGLKILGA-TASTDQWSVSVEKENPK-------HTTARVTAFRKEAESSLESGGNLTSEVF 367
            .|.:.||::|.| :|:.:.|::..|.:...       |.|.|..:.|:...:..
 Frog   259 VRCRTGLELLFARSAAPNTWAIKTEMQKGAKHHTVIGHVTHRGASERRPLPAVA----------- 312

  Fly   368 EVFSWLLEVAEDTNDIVDGGKIVWSVTHVYDTPKD----------KDSGELVIPDDNKKRLIAKL 422
                 ||:..  .::|..|..:...:|...|.|..          :.|.|:::.|
 Frog   313 -----LLDFL--VSNISVGSAVSRRITFQLDIPGSSVVAAAAAGVRGSAEVLVSD---------- 360

  Fly   423 EINKDDIQAVLPMAKIWEVMNTAVLTGRQVAQAMKVFIVSQAGKVADVTLQSSCHAEDESVIKVS 487
                .|::|:||:.|..|::|||.|||......::|..:...|.|.|||.|:.|...:..:::||
 Frog   361 ----RDLRAILPLVKSHEILNTAPLTGISQKIPVRVLAIEAGGTVLDVTKQAGCETPNAQIVQVS 421

  Fly   488 SSCSSVYVDGSEQRGSSNASVIVKYGTYVGVAKFIVWMPEFPLEVYISDFRLSQIKG-----WKV 547
            ..|..::|.|.|.:|:....|..............:|:|..||.:.:||..|.:::|     ..:
 Frog   422 DGCDFLFVGGKETQGALGVKVEFWLERLRASLSLSLWVPLLPLRIEVSDTNLQRLQGSGLVSTSL 486

  Fly   548 TDDNHYLHNKQSRRRKKRSYVWGQHGTNYYNNLGADKTICRARYQQSPVEVYAKFLAVDQNSGR- 611
            .||..  ..|.|..|:.:|                    ||..||::.|...|.|:|...:..|
 Frog   487 EDDGG--ERKTSSDRRSQS--------------------CRPLYQRARVRFLAYFVAHSLDGSRQ 529

  Fly   612 TSYFISRRTGLRVTDLVQPLLRVADPKIASL--KGRILQGKSMGRTDVQVLSPITGRVIGTKEIR 674
            .:|.:.....|.|:.|::....:.||.||.|  :|.||.|:..|.|.|:|.||::..::|.:.:.
 Frog   530 LTYLLGTDWLLDVSPLIRSQAVIRDPHIARLEEEGSILIGQEPGVTSVEVRSPVSHSILGEQTVL 594

  Fly   675 VGSDKVNLSKLIVRVISGLQLTISPDNTIENGYLAETSVTHKL-TAQYQEGLLDIDLEFTDGSKT 738
            |..:.|::.:|...::.|:.|::|.......|..:....::.| ....||..|.:...|:|.|..
 Frog   595 VSLETVSVLELRSNLMWGVNLSVSTAEIKHPGVFSVLCQSNNLEMIPKQESALSLWFLFSDFSTA 659

  Fly   739 PLRDIAVEDYFLLVESLDTEVVAF-APMLASHH---PRVIAVGEGNGNLLRVTLLLSEECRQRRG 799
            |:......|..::|.|.|..|::. .|::..:.   |.::....|...|||.::||.|.|
 Frog   660 PVNIYDPLDLTVMVVSSDPSVLSVRRPLMNGNSWSLPVLVFENAGQLPLLRFSILLPERC----- 719

  Fly   800 TLSSSKQNKSNAAPLASALASIEVDFNNVD---------IVSKQEAIQNDGTVGRERKN-YRQTG 854
                  |.:.::..|.:....:....|..:         |.|..:.|..||.:.....| ...|.
 Frog   720 ------QEEESSGVLTAGYVRVTFPSNRTEGGEHQSSDIIQSDSDLITKDGEMISSANNIIPGTN 778

  Fly   855 DLADIIVGIPLR----DSSQLYEPTVQARQHRGSIQAVHKGHHGKGLAGTGTMTTMELGMYVLLT 915
            |:  ||....:|    ||....:..:..|.               |:.|      :|.|:|.||.
 Frog   779 DI--IIRSDDIRHEDDDSISGADDIITTRW---------------GIPG------LEEGLYGLLA 820

  Fly   916 AFCFAIIVFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDWVWLG 980
            .|....::|::|||.:..:.|              |.:...|.|          ...|.:||||.
 Frog   821 IFSLLTLLFLLSCVAFIMRHR--------------KKSPPEGPG----------NPEAPNWVWLE 861

  Fly   981 RSTIDRQ 987
            ...:|.|
 Frog   862 GQEVDSQ 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:464813	29/117 (25%)
		TMEM132	440..796	CDD:465003	96/368 (26%)
		TMEM132D_C	881..982	CDD:464814	21/100 (21%)
tmem132a	XP_002942160.1	TMEM132	374..721	CDD:465003	96/379 (25%)
		TMEM132D_C	797..860	CDD:464814	20/107 (19%)