Protein Alignment dtn and tmem132c

DIOPT Version :10

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_017946466.2
• Gene: tmem132c / 100491050
• XenbaseID: XB-GENE-952799
• Length: 1088
• Species: Xenopus tropicalis
• Alignment Length: 1076
• Identity: 276/1076 - (25%)
• Similarity: 462/1076 - (42%)
• Gaps: 203/1076 - (18%)

  Fly    38 PVTPEIANVQTSSAVPPLRQRSSYDSVLS--LDRFTVVETTQPVSIRASYGPFSTKQTVPARYIV 100
            ||...|.:.:|:..:....|....:|.|.  ::.|.:.:..:...:.|||||||.:|.:
 Frog    40 PVNYRILSAETAFLLKENNQDFMRNSSLQSRVESFFIHKALKSPVLNASYGPFSVEQDI------ 98

  Fly   101 PDTMDSQSGDYMNNATLLELQQPNMHLDISAHLVRSSVSQDAPVLRVLFH-AGADPGGHLQRQKV 164
                   :.|.:.|.......:...:..|.|:::...|..:.|.::|||: ||.|...:...:|:
 Frog    99 -------TEDILLNTHSFGPNKFTFNWKIKAYIINEKVYPNKPKVQVLFYIAGRDWDNYSATEKL 156

  Fly   165 CVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPAPTQDGSGQAPPK-VPQRYAQVS 228
            ..|...|....:.:||.|..:|..|:||||:.....|:...|..|.....|..|: :|.......
 Frog   157 PCLRLFAFRETREVKGSCRLQGILGLCVAELEFQPSWFTSPPVITSRKRNQELPEGIPVDLYYTI 221

  Fly   229 YSVFEPPLRNPEQCEPKVQIQP-----------LTTFAQVPLLAARTP----YRMLRADDAVTFL 278
            .|..|......|:......|:|           :.....:.|.  |||    ...||.|..|...
 Frog   222 QSEEEKTECTAEEARKGNAIRPGKDPAEDALSHIQRIGNISLY--RTPESSQLTELRLDSHVALW 284

  Fly   279 LPQHPLY--PLSRLHVPVFLHQYPDQRVAAFTVRARVKAGLKILGATASTD-QWSVSVEKEN-PK 339
            ||..|..  .:..::|.|..:...||    |.:||:||.|:.||....|.. ||.:..|..| .|
 Frog   285 LPSKPAKQGEVLIVYVTVASNATLDQ----FILRAKVKKGVNILNVKISDPLQWDIQQELGNGGK 345

  Fly   340 HTTARVTAFRKEAESSLESGGNLTSEV----FEVFSWLLEVAEDTNDIVDGGKIVWSVTHVYDTP 400
            |:|..||..|..| |......|..:||    ||:.|:        :.:.....|.|.|.:
 Frog   346 HSTTSVTCQRTGA-SQRSRTNNQFNEVVQMNFEITSF--------SSLSGTQPISWQVEY----- 396

  Fly   401 KDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEVMNTAVLTGRQVAQAMKVFIVSQAG 465
            ..|.|.:::         ::::.|::.|:..::|::...|::|||:|||:.||..:|:..|.:.|
 Frog   397 PGKGSSDII---------LSEIFISQKDLVGIVPLSMDTEILNTAILTGKTVAVPVKIVSVEENG 452

  Fly   466 KVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNASVIVKYGTYVGVAKFIVWMPEFPL 530
            .|.|::.|..|.:.||.|:|||..|..|:|:|.|.:|.:..:|...|..........:|:|..||
 Frog   453 YVTDISEQVECKSSDEDVVKVSERCDYVFVNGKEMKGKTGVTVNFTYQYLTAPLHITIWVPRLPL 517

  Fly   531 EVYISDFRLSQIKGWKV-----------TDDNHYLHNKQSRRRKKRSYVWGQHGTNYYNNLGADK 584
            ::.|||..|||||||:|           :||    .::..||.:.
 Frog   518 QIDISDTELSQIKGWRVPIIANRRPTRDSDD----EDEDERRGRG-------------------- 558

  Fly   585 TICRARYQQSPVEVYAKFLAVDQNS-GRTSYFISRRTGLRVTDLVQPLLRVADPKIASLK-GRIL 647
              |..:||.:.|.|..:|:|.|.:. |:..:.:.......|||||...:::.:|.:|.|: ||:|
 Frog   559 --CSLQYQHATVRVLTQFVAEDSDPLGQLIFLLGSDWQFDVTDLVTDFMKLEEPHVAKLQDGRLL 621

  Fly   648 QGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLIVRVISGLQLTISPDNTIENGYLAETS 712
            .|:.:|.|.:||:||::..::..|.:.|..|||.::.|.|:::|||.|.:.|.......::|.::
 Frog   622 IGREVGMTTIQVMSPLSDSILAEKTVTVLDDKVTITDLGVQLVSGLSLFLQPSTANNKAFVATST 686

  Fly   713 VTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLLVESLDTEVVAFAPMLASHHPRVIAVG 777
            ....|....||.:|...::|:||..|||.....:|:.|...|||..:|:.........|.|:|.|
 Frog   687 AQELLHTPKQEAVLSTWIQFSDGMVTPLDIYDYKDFSLSATSLDDSIVSTYQRSLYKLPVVVAEG 751

  Fly   778 EGNGNLLRVTLLLSEECRQRR----------------GTLSSSKQ---------------NKSNA 811
            :|.|.:::|.:::||.|::.:                |...:|.|               ::...
 Frog   752 DGQGPVIKVDMMISEACQKSKRKSVLAIGYGFIKVKIGQKDTSPQTGNDYGGDEIENHTSDRKQK 816

  Fly   812 APLASALASIEVDFNNVDIVSKQEAIQNDGTVGRERKNYRQTGD-LAD--IIVGIPLRDSSQLYE 873
            ||......: |..:|...:...:.||:...|..|...|.|..|: |::  .:..||:..::  :.
 Frog   817 APDVEQYGN-EGRYNGSPLERDKSAIRKSSTTARSFLNSRVDGNRLSEDSPLQNIPIDFTN--FP 878

  Fly   874 PTVQARQHRGSIQAVHKGHHGKGLAGTGTMTTMELGMYVLLTAFCFAIIVFVISCVVYASKFRPA 938
            ..:...:..|.::.....|..|||      :.:|:|||.||..||.||:||:|:|..:|.|:|..
 Frog   879 AQIDLPKSNGEMEENDLVHAPKGL------SDLEIGMYALLGVFCLAILVFLINCATFALKYRHK 937

  Fly   939 MIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDWVWLGRST-------------------I 984
            .|     |:..                 :.|..::|||||||..|                   |
 Frog   938 QI-----PIEG-----------------QTSMAHSHDWVWLGNETELLENTPDVSPQQDEHTTII 980

  Fly   985 DRQSIVAETNTHLNPRDSRMRI----------TSNP 1010
            ||.:|:.| ::||...:::..:          |.||
 Frog   981 DRGTILDE-SSHLFNGNTQKSVQSQIHRQAEETENP 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:464813	30/134 (22%)
		TMEM132	440..796	CDD:465003	115/368 (31%)
		TMEM132D_C	881..982	CDD:464814	32/100 (32%)
tmem132c	XP_017946466.2	TMEM132D_N	41..168	CDD:464813	30/139 (22%)
		TMEM132	427..770	CDD:465003	115/368 (31%)
		TMEM132D_C	875..959	CDD:464814	32/113 (28%)