Protein Alignment dtn and tmem132b

DIOPT Version :10

• Sequence 1: NP_001284933.1
• Gene: dtn / 31555
• FlyBaseID: FBgn0262730
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_002935330.1
• Gene: tmem132b / 100489844
• XenbaseID: XB-GENE-6037549
• Length: 1091
• Species: Xenopus tropicalis
• Alignment Length: 1107
• Identity: 291/1107 - (26%)
• Similarity: 476/1107 - (42%)
• Gaps: 241/1107 - (21%)

  Fly    38 PVTPEIANVQTS----SAVPPLRQRSSYDSVLSLDRFTVVETTQPVSIRASYGPFSTKQTVPARY 98
            ||...:.|.:.|    ...|.|.:.||..  :..:...:.:...|..|.|:|||:|.:||||...
 Frog    52 PVNYHVCNAEVSFFLKEVNPDLTKNSSLQ--IRTEPLFIYKAKMPPVINATYGPYSAEQTVPKHL 114

  Fly    99 IVPDTMDSQSGDYMNNATLLELQQPNMHLDISAHLVRSSVSQDAPVLRVLFH-AGADPGG-HLQR 161
            :            |.::|.....:...:..|.:|::.||:..:.|.::.||: .|.|... |...
 Frog   115 M------------MTSSTFSSTNKFTFNWQIKSHIIESSIYSNNPKIQALFYITGKDWNDYHPSE 167

  Fly   162 QKVCVLLHVAMGSEQPLKGRCMPEGEDGVCVAEVVVPLGWWPQLPAPTQDGSGQAPPK-VPQRYA 225
            ...||.| ||:...:.:...|..:|..|:||||:.:...|.....|  :|.....||: ||....
 Frog   168 ILPCVRL-VALLENREISSSCRLKGSLGLCVAELELLPSWLGTSSA--EDLKDSVPPQGVPVELH 229

  Fly   226 QVSYSVFEPPLRNPEQC---EPK----VQIQ---------PLTTFAQVPLLAARTPYRM--LRAD 272
            .:.||..|     .|:|   |.|    :|.:         |:.....|.:..:....||  ||.|
 Frog   230 HIIYSTGE-----DEECLSAETKWTNSIQSESDSTQKVSPPMERIGSVVVYPSHNTLRMSVLRLD 289

  Fly   273 DAVTFLLPQHP-----LYPLSRLHV---PVFLHQYPDQRVAAFTVRARVKAGLKILGA-TASTDQ 328
            :.:....|..|     :...|.|.|   |.:          ..|:|.:...|.|||.. ...|:|
 Frog   290 NNIQIRFPPSPVKVGDIVTFSVLMVGGSPTY----------QLTLRVKTALGAKILYVRVTDTEQ 344

  Fly   329 WSVSVEKEN-PKHTTARVTAFRKEAESSLESGGNLTSEVFEVFSWLLEVAEDTNDIVDGGKIVWS 392
            |.|..:.|| .|:|||.:...|.  ...::|..|  ..::|:.....|:.. ::.:....:|.|.
 Frog   345 WKVQRQMENGDKYTTATLVCVRH--GPVIQSSTN--ESLYEILQMDFEMGL-SSGLAGAQQITWQ 404

  Fly   393 VTHVYDTPKDKDSGELVIPDDNKKRLIAKLEINKDDIQAVLPMAKIWEVMNTAVLTGRQVAQAMK 457
            |.:    |::....||         :|:::.:::.....::|:|...|::|||:||||.|:..:|
 Frog   405 VEY----PEEDSVSEL---------MISEIFVSQTTFAGIVPLAMDTELLNTAILTGRAVSVPVK 456

  Fly   458 VFIVSQAGKVADVTLQSSCHAEDESVIKVSSSCSSVYVDGSEQRGSSNASVIVKYGTYVGVAKFI 522
            |..|.|.|.|.||:..|.|.:.||.|||||..|.|::|:|.|.:...:..|...|..:....:..
 Frog   457 VVAVQQDGSVIDVSDFSECRSADEDVIKVSDRCDSIFVNGKEMKSKVDTIVNFTYQHFTTELEVT 521

  Fly   523 VWMPEFPLEVYISDFRLSQIKGWKV--------TDDNHYLHNKQSRRRKKRSYVWGQHGTNYYNN 579
            ||.|..||::.|||..|||||||::        |.|:   .:::...:|.|.
 Frog   522 VWAPRLPLQIEISDTELSQIKGWRIPVNMNKRPTRDS---EDEEDDEKKGRG------------- 570

  Fly   580 LGADKTICRARYQQSPVEVYAKFLAVDQNSGRTSYFISRRTGLRVTDLVQPLLRVADPKIASLK- 643
                   |..:||.:.|.|:.:|:|....:|:.:|.:.....:.:||||...::|.:|:||:|:
 Frog   571 -------CSLQYQHALVRVFTQFVAESSEAGQLTYMLGPDWQMDITDLVSDFMKVEEPRIATLEA 628

  Fly   644 GRILQGKSMGRTDVQVLSPITGRVIGTKEIRVGSDKVNLSKLIVRVISGLQLTISPDNTIENGYL 708
            |::|.|:..|.|.||||||::..::..|.:.|..|:|.:.:|.|::|:||.|::..:...:...|
 Frog   629 GKVLVGRDQGITTVQVLSPLSDSILAEKTVTVLDDRVGIVELGVQIITGLSLSVQANRLNKRAIL 693

  Fly   709 AETSVTHKLTAQYQEGLLDIDLEFTDGSKTPLRDIAVEDYFLLVESLDTEVVAFAPMLASHHPRV 773
            ..||.:..|....||.:|.:.:.|:|||.|||.....:|:.:||.|||..||:......|:.|.|
 Frog   694 TTTSASDILHDYKQEAVLSVWMLFSDGSVTPLDIYESKDFSVLVSSLDEMVVSAYQNPLSNWPVV 758

  Fly   774 IAVGEGNGNLLRVTLLLSEECRQRRGTLSSSKQNKSNAAPLASALASIEVDFNNVDI-------- 830
            :|.|||.|.|:::.|.:||.|::        .:.|||   ||....:::|.|...|.
 Frog   759 VAEGEGQGLLIKLELGISEICQK--------SKRKSN---LAVGSGTVKVKFGQKDSDQKAKINE 812

  Fly   831 ------------------VSKQEAIQND--------------------GTVGRERKNYRQTGDLA 857
                              |::||...|:                    .:.|...|||..
 Frog   813 IHTSDDDFKKHASKTTEKVAEQERTANEWPKHGSSISNFEDNNKNMTSDSPGDYHKNYYD----- 872

  Fly   858 DIIVGIPLRDSSQLYEPTVQARQHRGSIQAVHKGHHGKGLAGTGTMTTMELGMYVLLTAFCFAII 922
            ..|..:|:  :..::...:.:.:|....:...        |..| :|.:|:|||.||..||.||:
 Frog   873 GYIQIVPV--TYTIFPTRIVSSEHNRDSELTQ--------ASRG-LTDLEIGMYALLCVFCLAIL 926

  Fly   923 VFVISCVVYASKFRPAMIESGLDPLSAGKSNGSGGSGGFRDVRLKESTTNAHDWVWLGR------ 981
            ||:|:||.:|.|:|....     |: |.::|                ..::|||||||.
 Frog   927 VFLINCVAFAWKYRNKRF-----PV-ADQAN----------------IPHSHDWVWLGNEVELLE 969

  Fly   982 -------------STIDRQSIVAETNTHLNPRDSRMRITSNPIVNYDNGRRVSSFDQQPKLQTHI 1033
                         :.|||:....|:|..||....:     ||   |....:.|.::.:.  ..||
 Frog   970 NPADTPLPADECTTMIDRRPQFEESNFLLNGGSQK-----NP---YSQILQPSDYNYEK--DAHI 1024

  Fly  1034 VP 1035
            .|
 Frog  1025 EP 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dtn	NP_001284933.1	TMEM132D_N	18..170	CDD:464813	34/137 (25%)
		TMEM132	440..796	CDD:465003	126/364 (35%)
		TMEM132D_C	881..982	CDD:464814	32/119 (27%)
tmem132b	XP_002935330.1	TMEM132D_N	53..181	CDD:464813	35/142 (25%)
		TMEM132	439..781	CDD:465003	126/364 (35%)
		TMEM132D_C	885..964	CDD:464814	32/109 (29%)