Protein Alignment CG5937 and SYT1

DIOPT Version :10

• Sequence 1: NP_572289.2
• Gene: CG5937 / 31537
• FlyBaseID: FBgn0029834
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_015420.1
• Gene: SYT1 / 856210
• SGDID: S000006299
• Length: 1226
• Species: Saccharomyces cerevisiae
• Alignment Length: 1451
• Identity: 273/1451 - (18%)
• Similarity: 442/1451 - (30%)
• Gaps: 549/1451 - (37%)

  Fly   471 QSMARLPAPYRDAIVEFRQTVFETSSGSESE----------GEPQHEQDAASNGSGDT--EGPED 523
            :.|.||...:|.|          ...|||.:          |:...|....|..:.|:  :.|:.
Yeast    84 RKMGRLDLNFRSA----------NEKGSEDDEILVAQHLRNGQDPEEMPFKSENNIDSIEKVPKP 138

  Fly   524 DD-----PSSSSDETSRVENRWPYSHLEAPVMPIRTDSDNDRQHARDFARALR------QDLVPK 577
            |.     .||.||...|.....|:    .||.|......:..:.:||:.::..      ..|||.
Yeast   139 DGERVTLTSSGSDNVKRNSKHAPF----IPVKPALEKFPSSNRLSRDYRKSQEPTLFNGDRLVPT 199

  Fly   578 L-----LRLRSCVELDEAMQEFAS----AVCQENSMNFSDFDYN-LTAINADG---IYLAIYSSL 629
            |     :...|.|....|...:.:    ||...:|.:.|...:| |.||..|.   |.||.....
Yeast   200 LPTVSRISTSSSVGSSTAASRYFNPSKRAVVASSSSSSSSIKFNSLHAIPLDATPQIELAKQQDE 264

  Fly   630 LLSLQLMR-----AGFYEQVAQGMSHKDILVPMSEQQFVTSV--QNTGVLVYLSSPWLCELYQSV 687
            :...:..|     ...::.:.:..:.|: ..|:|...|:.::  :||..|:.
Yeast   265 ISKRRFGRRRSRTVDVFDYINKNNTAKN-KPPLSPSSFIRTIDEKNTNSLMQ------------- 315

  Fly   688 TVCNVLEAMPRQQLEGMGPRCALVD-----MLCDAGGLGATQMLSEWQRLQTANVKHKEEEQLHD 747
                          :.||.|..|:.     :..|..|               |...|.:.:.|..
Yeast   316 --------------DPMGSRGPLLPDDANIISNDTDG---------------AEASHPDHQVLSR 351

  Fly   748 KRREAAKKLCRRLLTCCWDSMVIVLSSGLGDLQTSSASNKLVALSKRTLRVKAKANKSNGEALYA 812
            .|                                          |:.|..|:.|..|..     :
Yeast   352 SR------------------------------------------SQSTSFVQGKGGKRK-----S 369

  Fly   813 MCLDGLHSAATLSNSLNLQHLAGKILNLLASNVCQTSGPRISASQAMSMDVVLTGGLNLGSYSAD 877
            :..:|.|      |.|.|.|               .|||....:...:.:..:||
Yeast   370 IEDEGYH------NKLGLPH---------------GSGPTSVYNNKSNANSTITG---------- 403

  Fly   878 CWPSIFAVCRHVSQLEHEIFSMQNPAISASPGSSRRDLETGEKLSNGNAQDKLNLS-----SIPI 937
                   :.|..|.:.:.:.|..|...|:...|.::.|:..::|     |.||::|     .:|.
Yeast   404 -------MSRRSSSIVNALSSFVNLRSSSLSSSRQQHLQQQQQL-----QQKLDVSLEDLPPVPA 456

  Fly   938 DD-DETCVDVYSFLQAPMQSPNTNITSILKVYSGTNETVLLSQSDTSKVLCALSHQAENLFG--- 998
            .: .::|.| :....||              |......:|..:.|..|..| |::...|.|.
Yeast   457 PEFSDSCKD-FLIKLAP--------------YGKFIGIILTEKDDEFKKNC-LNYLLTNCFEFKN 505

  Fly   999 ---DAAER-----LSLPSLCQFLKHLCRASRDQLYKSQVA---RKGSRIWWPSKGWKKLDS---L 1049
               |.|.|     |.||...|.:..|..|.....||:|.:   :||  |..|   |...|.   :
Yeast   506 DPLDIALRKLLMFLELPKETQQIDRLIMAFSFAYYKAQKSYSKKKG--IECP---WSNADQVYFI 565

  Fly  1050 PMSLL-LHRIGDVTLKVFRSSRPLLHVLKVWAITGPHLMDAACHRDRM-----ISKRAIEYIHDI 1108
            ..||| ||      ...|..:...       .:|....:|.. |.|:.     |....:.|.::.
Yeast   566 AFSLLMLH------TDYFNPNNKS-------KMTKHDFVDLV-HNDKYSGGNEIPMAVLTYFYEN 616

  Fly  1109 ITALLVEQSELPYFHFNEALLKPFENLLSMDTDVDVQDQIVACLYEVVEAHRTEIRSGWRPLFGT 1173
            :||     .|.|  .||..|:.|      |..|..:.|:         :|..|.        |..
Yeast   617 VTA-----KESP--KFNYFLMSP------MALDDSILDK---------DAFDTN--------FAI 651

  Fly  1174 LRNARSRMLNMSNIIDIFRVFLDSDNTLVFANAGLDCILC-LLSYLEISGGGNNNACS---GGSG 1234
            ..::.|    |.:.||:.:     ..:::...|.|..|.. |.:.:..||...:.|.|   ..||
Yeast   652 TLSSNS----MYSPIDMIK-----RGSIIPKEASLSPIFYPLTNSISASGIAPSTAASCPPSTSG 707

  Fly  1235 SAAG---GTASNGGQQEEDNTFRPTDFLHETLRFLERCSSILGFMHSMPKCPNFHSTYKIKGIS- 1295
            :..|   |||::...:...|:.                ||...:..|.....|  :|.....|:
Yeast   708 TINGANLGTANSNSNRPASNSI----------------SSYFSYNPSSSSSGN--ATLVQDDINV 754

  Fly  1296 YTHIIDANI------PSSMENFTYFGNDYLQT---RNEQ--YMISYRSLHIDKDTIVK-----ID 1344
            |:|||:..:      |   |...|:..:.|:.   |||:  |...|..::..|...::     ::
Yeast   755 YSHIINDTLNEVNLFP---EVSKYWNKNALKANLLRNEEHKYEKYYSIMNDTKGGYLRFHKSQLN 816

  Fly  1345 EMDKPSGVLKVWFLLLDGLTNSLIVCPYSHQAPILQTIFKLFKNL-------LASPGIDFGF--- 1399
            :::.|:      |.:|:  .||...|..|.        :|..|.|       |..|...|..
Yeast   817 KLNLPN------FEILN--DNSRSGCKNSD--------YKYCKILQMGAIMNLGMPSRKFSIVNS 865

  Fly  1400 --------YCINHLLVPMIQDWLRYIN-------KTGSSWQLVEKNFKHCCCMTTDLVVEFIEKS 1449
                    :.|...|..:|.|.:.:||       |:|                ||:.:::|  ||
Yeast   866 AKIHWKKEFAILTSLGLLICDKMDWINPQMMKDPKSG----------------TTNYIIDF--KS 912

  Fly  1450 ----VP--------------EQRRLGAGTKTRLAQIVHPADNLLYSKLKFVTERIEREQQQQQSP 1496
                ||              |:..||   |:..|.:|     |.|:
Yeast   913 GFSFVPGSTIDVYNGLFADRERDSLG---KSHFASLV-----LAYT------------------- 950

  Fly  1497 SVQDHGCG-YTQQYDSSSSSA----------SEEQQKNGGGVGGGGSNLIESPTKISGSATLALK 1550
              :.|..| :|....::||||          |:|:........|..|  :.:....:.|.:.:..
Yeast   951 --EHHSTGSHTSNTTAASSSAKHNEGVFEPSSDEEDSITNSTDGTSS--VSNGESDNDSVSSSDN 1011

  Fly  1551 QLLLVLIECAAQSQEAIARI----------SVSCL-------KHVILSTGMLFNESQWM--IACS 1596
            ||      .:..|.|....|          :..||       ::.|......:....|:  |...
Yeast  1012 QL------SSNDSNEDYHSIKDEYPIFEDENADCLLYLHTCHRNFIWKCANKYERDNWIDSINLF 1070

  Fly  1597 AIHRACTVTIAP-------------------LRQLSFAFHEKSNSF------YGDCANVKVAARR 1636
            :.:..|.|.|..                   ||.:..|..||...|      .|.|..:....:.
Yeast  1071 SAYDGCYVEIGSIANTICNKRKLTILQRMERLRSIKSAKWEKLKKFESTLMLMGKCVPISTKTKT 1135

  Fly  1637 D--SSLEELA-----RIYALAQ-QVFLS-----------------DNQREPGQNQAPTPSASQCK 1676
            |  :.:.:||     .||.:.: ::|:|                 ....|.||........
Yeast  1136 DMINRIRQLAVRMDWLIYEIKRSELFVSIIKEVTRKQAEKNILEHGKGEEEGQGNNDDSDG---- 1196

  Fly  1677 LSDDRSYSFLLYPLNNGFNSN 1697
             .||...|||       ||.|
Yeast  1197 -IDDIEESFL-------FNEN 1209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5937	NP_572289.2	Sec7	451..692	CDD:469626	52/263 (20%)
		DUF1981	1115..>1177	CDD:462756	12/61 (20%)
SYT1	NP_015420.1	Sec7	443..622	CDD:214569	48/218 (22%)