Protein Alignment CG5937 and GEA1

DIOPT Version :10

• Sequence 1: NP_572289.2
• Gene: CG5937 / 31537
• FlyBaseID: FBgn0029834
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_012565.1
• Gene: GEA1 / 853488
• SGDID: S000003792
• Length: 1408
• Species: Saccharomyces cerevisiae
• Alignment Length: 1618
• Identity: 296/1618 - (18%)
• Similarity: 510/1618 - (31%)
• Gaps: 557/1618 - (34%)

  Fly   229 NHSSLYLTECILTLSSALPRNVHANPHFTSFLWQKFCPTLAAALGSPGRINLDKKFTYKDALHMI 293
            |.:::.:.||| .|.||:.:...          .|...::||.||....|.|.:..::.|:.|.:
Yeast    13 NPATMIVKECI-NLCSAMNKQSR----------DKSQTSVAALLGGGSDIFLSQSDSFVDSFHNL 66

  Fly   294 ENEARGFFTGP----------------GLDGPQARCVYLTAIQLLRIAGAHGSLRPMLEAL---- 338
            ...:   :..|                |||.       |.|::|         |:|.||.:
Yeast    67 PTSS---YHDPLISGLVQLRLKINDLKGLDS-------LNALEL---------LKPFLEIVSASS 112

  Fly   339 ---FHRMLLLPAPQNRTEPLRCVREIFKSPERLIDLAVILYVDKNTAQGCSDEMALFRLLVDAME 400
               :...|.|.:.| :...|:.:.:.|..    |.:||                   |..|.|:.
Yeast   113 VSGYTTSLALDSLQ-KVFTLKIINKTFND----IQIAV-------------------RETVVALT 153

  Fly   401 ECAYGASGGGSATEASLQASVEC----MVALLDSLQVLCSGE-LTESMISDQIVQVVN-----GR 455
            .|.:         |||.|.|.:.    :|.||..:.....|: |::::|.|.:...::     .|
Yeast   154 HCRF---------EASKQISDDSVLLKVVTLLRDIITSSFGDYLSDTIIYDVLQTTLSLACNTQR 209

  Fly   456 HDLL-KDADYS-GPLT---YQSMARLPAPYRDAIVEFRQTVFETSSGSESEGEPQHEQDAASNGS 515
            .::| |.|:.: ..:|   :..:..|..|          |..|.....||..:...:.|.....:
Yeast   210 SEVLRKTAEVTIAGITVKLFTKLKLLDPP----------TKTEKYINDESYTDNNLKDDIIGTTT 264

  Fly   516 GDTEGPEDDDPSSSSDETSRVENRWPYSHLEAPVMPIRTDSDNDRQHAR-------DFARALRQD 573
            .|.:....||.|:.:|:...          |.||..:..:.:||.:.|.       ::...:.:|
Yeast   265 SDNDLSSTDDDSAVADDNKN----------EKPVQQVIREQENDEETAEKAENVEPNYGITVIKD 319

  Fly   574 LVPKLLRLRSCVELDEAMQEFASAVCQENSMNF--SDFDYNLTAINA------------------ 618
            .:..||                |.|..||.|..  |....:|..|||
Yeast   320 YLGLLL----------------SLVMPENRMKHTTSAMKLSLQLINAAIEISGDKFPLYPRLFSL 368

  Fly   619 --DGIYLAI---------YSSLLLSLQLMRA-----GFYEQVAQGMSHKDILVPMSEQQFVTSVQ 667
              |.|:.::         ||.|..:|||..:     |.|..:...::.:.|...:.:......|.
Yeast   369 ISDPIFKSVLFIIQSSTQYSLLQATLQLFTSLVVILGDYLPMQIELTLRRIFEILEDTTISGDVS 433

  Fly   668 NTG-------VLVYLSSPWL--------------CELYQSVTVCNVLEAMPRQQLEGMGPRCAL- 710
            ...       ::..||..|:              |.|.:|....:.::.:.:..|    |..|:
Yeast   434 KQKPPAIRELIIEQLSILWIHSPAFFLQLFVNFDCNLDRSDLSIDFIKELTKFSL----PAAAVN 494

  Fly   711 ----VDMLCDAGGLGATQ-MLSEWQRLQTAN-VKHKEEEQLHDKR-------------REAAKKL 756
                :..:|..|.|...: :.::.||...|. ||:::|..:..:|             .|.|||
Yeast   495 TSNNIPPICLEGVLSLIENIYNDLQRFDRAEFVKNQKEIDILKQRDRKTEFILCVETFNEKAKK- 558

  Fly   757 CRRLLTCCWDSMVIVLSSGLGDLQTSSASNKLVA---------LSKRT---LRVKAKANKSNGEA 809
                      .:.:::..|..|    |.||:.:|         |:|:|   |....|......|.
Yeast   559 ----------GIQMLIEKGFID----SDSNRDIASFLFLNNGRLNKKTIGLLLCDPKKTSLLKEF 609

  Fly   810 LYAMCLDGLHSAATLSNSLNLQHLAGKILNLLASNVCQTSGPRISASQAMSMDVV----LTGGLN 870
            :......||.....:...|....|.|:...:  ..:.:....:.||.|  |.|.|    ...|.|
Yeast   610 IDLFDFKGLRVDEAIRILLTKFRLPGESQQI--ERIVEAFSSKYSADQ--SNDKVELEDKKAGKN 670

  Fly   871 LGSYS------------ADCWPSIFAVCRHVSQLEHEIFSMQNPAISASPGSSRRDLETGEKLSN 923
             ||.|            ||   |:|.:...:..|..:   ..||.:        :|..|.:..||
Yeast   671 -GSESMTEDDIIHVQPDAD---SVFVLSYSIIMLNTD---SHNPQV--------KDHMTFDDYSN 720

  Fly   924 G-----NAQD-----------KLNLSSIPIDDDE---------------TCVDVYSFLQAPMQSP 957
            .     |.:|           .:.:..|.:.::.               :...|.:.:|....:|
Yeast   721 NLRGCYNGKDFPRWYLHKIYTSIKVKEIVMPEEHHGNERWFEDAWNNLISSTSVMTEMQRDFTNP 785

  Fly   958 NTNITSI------LKVYSGTNETVLLSQSDTSKVLCALSHQAENLFGDAAERLSLP-----SLCQ 1011
            .:.:..|      ..::|...:.:|       |.|..:...|      :::::||.     |.|.
Yeast   786 ISKLAQIDILQYEKAIFSNVRDIIL-------KTLFKIFTVA------SSDQISLRILDAISKCT 837

  Fly  1012 FLKHLCRASRDQLYKSQVARKGSRIWWPSKGWK----KLDSLPMSLLLHRIGDVTLKVFRSSRPL 1072
            |:.:.  .|.||.|...|...|..........|    .:||:|:..:.  :.|...|:..|::.:
Yeast   838 FINYY--FSFDQSYNDTVLHLGEMTTLAQSSAKAVELDVDSIPLVEIF--VEDTGSKISVSNQSI 898

  Fly  1073 -------------LHVLKVWAITGPHLMDAACHRDRMISKRAIEYIHDIITAL---LVEQSELPY 1121
                         |:...:..|:.|.:          :|.|....|..:|..|   |:.:..||:
Yeast   899 RLGQNFKAQLCTVLYFQIIKEISDPSI----------VSTRLWNQIVQLILKLFENLLMEPNLPF 953

  Fly  1122 FHFNEALLKPFENLLSMDTDVDVQDQIVACLYEVVEAHRTEIRSGWRPLFGTLRNARSRMLNMS- 1185
            |....:||| ...|...|.|:.:                                   |...||
Yeast   954 FTNFHSLLK-LPELPLPDPDISI-----------------------------------RKAKMSR 982

  Fly  1186 NIIDIFRVFL-----DSDNTLVFANAGLDCILC---LLSYLEISGGGNNNACSGG------SGSA 1236
            :::..|..:|     .|:..:.|:....:|:..   |.|..|     ||...|..      |...
Yeast   983 SLLSTFASYLKGDEEPSEEDIDFSIKAFECVKASHPLSSVFE-----NNQLVSPKMIETLLSSLV 1042

  Fly  1237 AGGTASNGGQQEEDNTFRPTDFLHETLRFLERCSSILGFMHSMPKCPNFHSTYKIKGISYTHIID 1301
            ...|:.|            :.:..:.|.||...|.||                 |...||.....
Yeast  1043 IEKTSEN------------SPYFEQELLFLLEISIIL-----------------ISEASYGQEFG 1078

  Fly  1302 ANIPSSMENFTYFGNDYLQTRNEQYMISYRSLHIDKDTIVKIDEMDKPSGVLKVWFLLLDGLTNS 1366
            |.|...|.|.:..  |.|.......:.||:        :..:...|.|..:|           :.
Yeast  1079 ALIADHMINISNL--DGLSKEAIARLASYK--------MFLVSRFDNPRDIL-----------SD 1122

  Fly  1367 LIVCPYSHQAPILQTIF--KLFKNLLASPGIDFGFYCINHLLVPMIQDWLRYIN---KTGSSWQL 1426
            ||    .|...:...||  |.:::       ::|...||.|...:  :.::|..   |....|
Yeast  1123 LI----EHDFLVKNEIFNTKYYES-------EWGKQVINDLFTHL--NDVKYNERALKNVKFW-- 1172

  Fly  1427 VEKNFKHCCCMTTD---LVVEFIEKSVPEQRRLGAGTKTRLAQIVHPADNLLYSKLKFVTE---- 1484
               ||........|   .|..|:||.:....             :...|....:.|..:.|
Yeast  1173 ---NFLRILISAKDRQFAVYTFLEKYIQNGD-------------IFVDDGNFMNILSLLDEMSCA 1221

  Fly  1485 -RIEREQQQQQSPSVQDHGC------GYTQQYDSSSSS-------------ASEEQQKNG--GGV 1527
             .:..:.:|....||:| ||      .|....|.||.|             ::....||.  ..:
Yeast  1222 GAVGTKWEQNYENSVED-GCEAPESNPYRSIIDLSSRSINITADLLSTVGRSNSALNKNEIIAAI 1285

  Fly  1528 GGGGSNLIESPTKISGSATLALKQLLLVLIECAAQSQEAIARISVSCLKHVILSTGML 1585
            .|.....:....::...|..||:.:||     :..||....:::|..|    |.||:|
Yeast  1286 QGLAHQCLNPCDELGMQALQALENILL-----SRASQLRTEKVAVDNL----LETGLL 1334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5937	NP_572289.2	Sec7	451..692	CDD:469626	54/314 (17%)
		DUF1981	1115..>1177	CDD:462756	9/61 (15%)
GEA1	NP_012565.1	Sec7_N	328..471	CDD:463703	25/142 (18%)
		Sec7	541..748	CDD:460178	45/240 (19%)