DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5966 and Lpl

DIOPT Version :10

Sequence 1:NP_572286.1 Gene:CG5966 / 31532 FlyBaseID:FBgn0029831 Length:540 Species:Drosophila melanogaster
Sequence 2:NP_036730.1 Gene:Lpl / 24539 RGDID:3017 Length:474 Species:Rattus norvegicus


Alignment Length:355 Identity:113/355 - (31%)
Similarity:172/355 - (48%) Gaps:34/355 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 SEIEPHFTLHT-RRALDQPKYLDLNDPESVQGMGMNPKGKIFLLVHGYLESGEI-PWMWDMAKAL 136
            |:||..|.|.| ....:...:|.....:||.....|...|.|:::||:..:|.. .|:..:..||
  Rat    35 SDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAAL 99

  Fly   137 LAHEPEGRASVVLIDWGGGASPPYVQAVANIRLVGAITAHVVHMLYEELRLPNLDNVHIIGHSLG 201
            ...||:  ::|:::||...|...|..:....:|||...|..::.|.||...| |||||::|:|||
  Rat   100 YKREPD--SNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWLEEEFNYP-LDNVHLLGYSLG 161

  Fly   202 AHLSGYAGYHLQHDFGLKPARITGLDPAAPLFTDTDPIVRLDKTDAHFVDIVHTDANPLMKGGLG 266
            ||.:|.||.....    |..||||||||.|.|...:...||...||.|||::||.........:|
  Rat   162 AHAAGVAGSLTNK----KVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIG 222

  Fly   267 INMRLGHVDFFPNGGFDNPGCN-KKFQDVVKKKTLFLTMQEFLGCNHIRSQQYFTES-IGSQCPF 329
            |...:||||.:||||...|||| .:...|:.:|.|. .:.:.:.|:|.||...|.:| :..:.|.
  Rat   223 IQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAEKGLG-DVDQLVKCSHERSIHLFIDSLLNEENPS 286

  Fly   330 LGITCDSFESFKDTKCTSCEEPGHTCLRMGYHSQEDYQEQVDLGQLQQGDSPGVFYLWTGDSKPF 394
            ....|:|.|:|:...|.||.:  :.|..:||          ::.:::...| ...||.|....|:
  Rat   287 KAYRCNSKEAFEKGLCLSCRK--NRCNNVGY----------EINKVRAKRS-SKMYLKTRSQMPY 338

  Fly   395 CRLHYRITVRVSGHD---------ESTLHG 415
            ...||::.:..||.:         |.:|:|
  Rat   339 KVFHYQVKIHFSGTENDKQNNQAFEISLYG 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5966NP_572286.1 Pancreat_lipase_like 76..390 CDD:238363 104/317 (33%)
LplNP_036730.1 Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 32..53 6/17 (35%)
lipo_lipase 33..472 CDD:132274 113/355 (32%)
Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858 243..266 5/23 (22%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858 417..421
Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858 430..434
Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 443..467
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.