Protein Alignment CG5966 and Lpl

DIOPT Version :10

• Sequence 1: NP_572286.1
• Gene: CG5966 / 31532
• FlyBaseID: FBgn0029831
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_032535.2
• Gene: Lpl / 16956
• MGIID: 96820
• Length: 474
• Species: Mus musculus
• Alignment Length: 441
• Identity: 125/441 - (28%)
• Similarity: 202/441 - (45%)
• Gaps: 41/441 - (9%)

  Fly    74 SEIEPHFTLHT-RRALDQPKYLDLNDPESVQGMGMNPKGKIFLLVHGYLESGEI-PWMWDMAKAL 136
            |:||..|.|.| ....:...:|.....:||.....|...|.|:::||:..:|.. .|:..:..||
Mouse    35 SDIESKFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAAL 99

  Fly   137 LAHEPEGRASVVLIDWGGGASPPYVQAVANIRLVGAITAHVVHMLYEELRLPNLDNVHIIGHSLG 201
            ...||:  ::|:::||...|...|..:....:|||...|..::.:.||...| |||||::|:|||
Mouse   100 YKREPD--SNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYP-LDNVHLLGYSLG 161

  Fly   202 AHLSGYAGYHLQHDFGLKPARITGLDPAAPLFTDTDPIVRLDKTDAHFVDIVHTDANPLMKGGLG 266
            ||.:|.||.....    |..||||||||.|.|...:...||...||.|||::||.........:|
Mouse   162 AHAAGVAGSLTNK----KVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIG 222

  Fly   267 INMRLGHVDFFPNGGFDNPGCN-KKFQDVVKKKTLFLTMQEFLGCNHIRSQQYFTES-IGSQCPF 329
            |...:||||.:||||...|||| .:...|:.::.|. .:.:.:.|:|.||...|.:| :..:.|.
Mouse   223 IQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLG-DVDQLVKCSHERSIHLFIDSLLNEENPS 286

  Fly   330 LGITCDSFESFKDTKCTSCEEPGHTCLRMGYHSQEDYQEQVDLGQLQQGDSPGVFYLWTGDSKPF 394
            ....|:|.|:|:...|.||.:  :.|..:||          ::.:::...| ...||.|....|:
Mouse   287 KAYRCNSKEAFEKGLCLSCRK--NRCNNLGY----------EINKVRAKRS-SKMYLKTRSQMPY 338

  Fly   395 CRLHYRITVRVSGHDESTLHGGEVGILSIQLHDALVKKAGKNERAATEMMKFSQKAMYFEPGYEY 459
            ...||::.:..||.::...|.   ....|.|:..:         |.:|.:.|:...:.....|.:
Mouse   339 KVFHYQVKIHFSGTEDGKQHN---QAFEISLYGTV---------AESENIPFTLPEVSTNKTYSF 391

  Fly   460 KALVAGRNLREPEYATVNWEYPTNILNPLTWRILSAPRIYLEYILIEAMES 510
             .:....::.|.....:.|...:....|..|   |:|...:|.|.::|.|:
Mouse   392 -LIYTEVDIGELLMMKLKWISDSYFSWPDWW---SSPSFVIERIRVKAGET 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5966	NP_572286.1	Pancreat_lipase_like	76..390	CDD:238363	102/317 (32%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	32..53		6/17 (35%)
		lipo_lipase	33..472	CDD:132274	125/441 (28%)
		Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858	243..266		4/23 (17%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858	417..421		1/3 (33%)
		Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858	430..434		1/3 (33%)
		Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	443..467