DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mof and KAT8

DIOPT Version :9

Sequence 1:	NP_511051.1	Gene:	mof / 31518	FlyBaseID:	FBgn0014340	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_892003.2	Gene:	KAT8 / 84148	HGNCID:	17933	Length:	467	Species:	Homo sapiens

Alignment Length:	438	Identity:	234/438 - (53%)
Similarity:	310/438 - (70%)	Gaps:	49/438 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 GDPLMQKIDISENPDKIYFIRREDGTVHRGQVLQSRTTENAAAPDEYYVHYVGLNRRLDGWVGRH 430
            |:|.: .::|.|.    |..||.|.|.|..:|:|||..:.... :|:||||||.|||||.||.::
Human    49 GEPEV-TVEIGET----YLCRRPDSTWHSAEVIQSRVNDQEGR-EEFYVHYVGFNRRLDEWVDKN 107

  Fly   431 RISDNADDLGGITVLPAPPLAPDQPSTSREMLAQQAAAAAAASSERQKRAANKDYYLSYCENSRY 495
            |::                            |.:....|...:||:         |||    ...
Human   108 RLA----------------------------LTKTVKDAVQKNSEK---------YLS----ELA 131

  Fly   496 DYSDRKMTRYQKRRYDEINHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYEIDTWYFSP 560
            :..:||:||.|||::||||||||::||:..|.||||||||:|||:||:||:..||||||.|||||
Human   132 EQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSP 196

  Fly   561 FPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNGKEESLYCQ 625
            |||:|||...|::||||||||::..||.:||.:|..|:|||:|||||.|||:|||:||:..:|||
Human   197 FPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQ 261

  Fly   626 LLCLMAKLFLDHKVLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACILVLPPHQRK 690
            .|||:||||||||.||||::||:||||.|.|::|:||||||||||:|.:..||||||.|||:||:
Human   262 NLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRR 326

  Fly   691 GFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLLELMKTRCAPEQITIKELSEMS 755
            |:||.|||||||||:.|..:|||||||||||:|||||||::.|||::  |.....::||:||:|:
Human   327 GYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEIL--RDFRGTLSIKDLSQMT 389

  Fly   756 GITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQLPQFKQPKLT 803
            .||.:|||.||||:.|:||||||:|||||.|.:::||:..|:|:|.:|
Human   390 SITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPIT 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mof	NP_511051.1	Tudor-knot	382..432	CDD:288553	24/49 (49%)
		NAT_SF	528..813	CDD:302625	180/276 (65%)
		MOZ_SAS	599..778	CDD:280097	119/178 (67%)
KAT8	NP_892003.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		2/3 (67%)
		PLN00104	15..429	CDD:215056	230/428 (54%)
		Tudor-knot	55..111	CDD:288553	27/88 (31%)
		NAT_SF	160..427	CDD:302625	176/268 (66%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:21217699, ECO:0000269\|Ref.22	317..319		1/1 (100%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:21217699, ECO:0000269\|Ref.22	324..330		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144782
Domainoid	1	1.000	263	1.000	Domainoid score	I1940
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41676
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1453
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285390at33208
OrthoFinder	1	1.000	-	-		FOG0005248
OrthoInspector	1	1.000	-	-		oto88574
orthoMCL	1	0.900	-	-		OOG6_100632
Panther	1	1.100	-	-	LDO	PTHR10615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R415
SonicParanoid	1	1.000	-	-		X828
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790