DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mof and mst1

DIOPT Version :9

Sequence 1:	NP_511051.1	Gene:	mof / 31518	FlyBaseID:	FBgn0014340	Length:	827	Species:	Drosophila melanogaster
Sequence 2:	NP_594630.1	Gene:	mst1 / 2543506	PomBaseID:	SPAC637.12c	Length:	463	Species:	Schizosaccharomyces pombe

Alignment Length:	460	Identity:	172/460 - (37%)
Similarity:	262/460 - (56%)	Gaps:	73/460 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 EDGTVHRGQVL--QSRTTENAAAPDEYYVHYVGLNRRLDGWVGRHRISDNADDLGGITVLPAPPL 450
            :||...:.::|  |.||....     |||||...|:|||.|:    ..||.|...||..   ||
pombe    31 KDGEYRKAEILMIQKRTRGVV-----YYVHYNDYNKRLDEWI----TIDNIDLSKGIEY---PP- 82

  Fly   451 APDQP--------STSREMLAQQAAAAAAAS--------------------SERQKRAANKDYYL 487
             |::|        |:.|.....:..:..|.|                    |:....|.|:.  |
pombe    83 -PEKPKKAHGKGKSSKRPKAVDRRRSITAPSKTEPSTPSTEKPEPSTPSGESDHGSNAGNES--L 144

  Fly   488 SYCENSRYDYSDRKMTRYQKRRYDEINHVQKSHAELTATQAALEKEHESITKIKYIDKLQFGNYE 552
            ...|.   |:....:::.|:        |::    |..:.:.::..|| |.:|:.|:|:..|::|
pombe   145 PLLEE---DHKPESLSKEQE--------VER----LRFSGSMVQNPHE-IARIRNINKICIGDHE 193

  Fly   553 IDTWYFSPFPEEYGKARTLYVCEYCLKYMRFRSSYAYHLHECDRRRPPGREIYRKGNISIYEVNG 617
            |:.|||||:|:|:.:...:|:|.:|..|......:..|..:|..:.|||.||||...||.:|::|
pombe   194 IEPWYFSPYPKEFSEVDIVYICSFCFCYYGSERQFQRHREKCTLQHPPGNEIYRDDYISFFEIDG 258

  Fly   618 KEESLYCQLLCLMAKLFLDHKVLYFDMDPFLFYILCETDKEGSHIVGYFSKEKKSLENYNVACIL 682
            :::..:|:.:||::|||||||:||:|:||||||.:|..|:.|.|:||||||||:|.||||:||||
pombe   259 RKQRTWCRNICLLSKLFLDHKMLYYDVDPFLFYCMCRRDEYGCHLVGYFSKEKESSENYNLACIL 323

  Fly   683 VLPPHQRKGFGKLLIAFSYELSRKEGVIGSPEKPLSDLGRLSYRSYWAYTLLEL---MKTRCAPE 744
            .||.:||.|:|||||.|||||:::|...|||||||||||.:|||:|||..::.|   |:|
pombe   324 TLPQYQRHGYGKLLIQFSYELTKREHKHGSPEKPLSDLGLISYRAYWAEQIINLVLGMRT----- 383

  Fly   745 QITIKELSEMSGITHDDIIYTLQSMKMIKYWKGQNVICVTSKTIQDHLQLPQFKQPKLTIDTDYL 809
            :.||.||:..:.:|.:|:::|||::.|:||:|||.:||::....|.:.:|...|:.:  |:.|.|
pombe   384 ETTIDELANKTSMTTNDVLHTLQALNMLKYYKGQFIICISDGIEQQYERLKNKKRRR--INGDLL 446

  Fly   810 V-WSP 813
            . |.|
pombe   447 ADWQP 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mof	NP_511051.1	Tudor-knot	382..432	CDD:288553	16/45 (36%)
		NAT_SF	528..813	CDD:302625	133/288 (46%)
		MOZ_SAS	599..778	CDD:280097	100/181 (55%)
mst1	NP_594630.1	SAS2	16..447	CDD:227360	169/454 (37%)
		Tudor-knot	21..74	CDD:288553	18/51 (35%)
		NAT_SF	176..451	CDD:302625	133/282 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100632
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R415
SonicParanoid	1	1.000	-	-		X828
TreeFam	0	0.000	Not matched by this tool.
	5	4.740