DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42699 and Cep162

DIOPT Version :9

Sequence 1:	NP_572263.2	Gene:	CG42699 / 31507	FlyBaseID:	FBgn0261610	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001263989.1	Gene:	Cep162 / 300880	RGDID:	1307365	Length:	1403	Species:	Rattus norvegicus

Alignment Length:	1089	Identity:	208/1089 - (19%)
Similarity:	382/1089 - (35%)	Gaps:	376/1089 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PHKQ------------GV-SEADALDYTNSSSIIEFLAKEQDCGGILNDPDPESIFQEVSRLSDS 58
            ||:|            || |...|.:.......:|.|.|:......|...|.::.....||||
  Rat   406 PHEQDESVVLHRTAGEGVGSSCPATEEHLDKMYLEILRKKTSVNPSLLPQDNKANQTSRSRLS-- 468

  Fly    59 TDMRSVDELLQEAERLIQQQLRLGGIVP-KLDASGPPAPTKT----LGEEAATGGDGSSSSP--- 115
                     .:|...:..:|      || |...|.||.|.:.    |...|.:.|....|||
  Rat   469 ---------AREEAPVTSKQ------VPCKKARSAPPLPRRKPQSGLYASARSSGYSKPSSPLQF 518

  Fly   116 ------QSSPHSSIRLNTRYTHRIEHSPAPLA---PKTVAVNGR--VRPRSGSKSS----ASPTS 165
                  ::|..::...|.|        |.|.:   .|...::|.  ::|.:.:|.|    .||.:
  Rat   519 FSALEKKTSKDNTKTKNVR--------PIPTSNQFRKREILSGTKLIKPAALNKPSPHREGSPAT 575

  Fly   166 VQTPLESSNGCGFAAFVDNLPS------------------------ASVISEE----STPKDMDM 202
            .:.|.:.|:........:.|.|                        |..:.|:    .:.|:.::
  Rat   576 PKRPEDPSDDSFVQLQTETLGSYGGNREKELLMLKRAQDAEEKWRGAQALIEQIKMTFSEKEKEL 640

  Fly   203 ENHTAAMAKLQLQQL----QDN------------------------TDDD------EDTMEEITE 233
            ||...::.:.|.::|    |:|                        |.|.      :...:||.|
  Rat   641 ENTVESLKRQQERELFKLNQENYILQAKLSSFEETSRKQRWLQFGETSDPLTEEKLKQIQKEIQE 705

  Fly   234 AEV--------DAPIFSRAEDTGKEVRSPPERQFKSQGRSYIQPSQPIRPMASYSE--------- 281
            .|.        :..::|:.:|..::.:...||.||.....:.:       :||..|
  Rat   706 QETLLQGYQQENERLYSQVKDLQEQNKKNEERMFKENQNLFSE-------LASLKEQMHKNHFLP 763

  Fly   282 KAVGSSPKRMVSTLTSPIEQI-ASSVSREH-------------ALKLEIEQL---QERLKD---- 325
            :||.:.......:.|..:.:: |:...:.|             ||::::|::   :::.||
  Rat   764 QAVENIEPTKNQSFTDLLAELRAAQKEKNHLMEDIKRLKQDKQALEVDLERVKRERDQAKDQIAY 828

  Fly   326 -TEERLASVRLQSDSLSQTQRALREHNSRLQEESEMLKLDVQHL---NECANVLRSELQAARRDR 386
             |.|:|..:::..::..|....|::......|..|:|..|...|   ||....|:.|::..:.:.
  Rat   829 TTGEKLYEIKILEETHKQEVSRLQKRLQWYAENQELLDKDAARLREANEETERLKLEIEKLKTES 893

  Fly   387 GEALQMQRSLRDELEEANQERRRTGEGKEKDSRVIQDLQRQCREMERILMRKHPDSVSALIVASK 451
            |             ..|||:|.|:.| :..|::.||||:||.:|||.||.|::|:|:.|||:|:.
  Rat   894 G-------------SPANQQRLRSKE-RALDAKRIQDLERQVKEMEGILKRRYPNSLPALILAAS 944

  Fly   452 SSGMCPLNDQENVNSRKLLEQRIAQLESDAKEQDRKAQQILANVQARFNSVQAKYETHIADLETQ 516
            ::|     |..:.|:...:|:||.:||:|.:.:|.:|::.|..::.:|..::.:||
  Rat   945 AAG-----DSVDRNTVDFMERRIKKLEADLEGKDEEAKKSLRTMEQQFQKMKIQYE--------- 995

  Fly   517 VLSLQEINTKLNEQIESQVRTLDRYMQKRADRYYNNCTQTEPLEEDDVSVGGGVNHGRATPVSSN 581
                        :::|.|.:.|....::.....:|:.::.:.||.:    .||:...
  Rat   996 ------------QRLEEQEQMLAHRQREAPQNQHNSSSRLKALETE----LGGIKEA-------- 1036

  Fly   582 TMGTQTQAANGTRDHSTNTIGCPSPALVCQQQHLHQAHGHLHPHAPSASSSTSSTANSTPNTSRP 646
                          |........:...|.:.|:.|..|                         :.
  Rat  1037 --------------HQITVRKLEAEIDVLKHQNAHLEH-------------------------KK 1062

  Fly   647 NSKQSGGQRRSPLVTAGPSKLPISQSDSTLSLLSHGGGGSKEEAQLLSSVRSMRVDLAIKNKAMQ 711
            |.|:                      |..|..:..    ..|:||..:.:..:..:||.|.:.:|
  Rat  1063 NDKE----------------------DQDLQSIEF----QVEQAQARAKLARLNEELAAKGREIQ 1101

  Fly   712 RLTRELDECKKTIRKLQRDKEGSGSGSQTGSKL--DLRSQASGGAMQQRRSSG---YDHHHHSD- 770
            .||:.::..:|..|.:...:...|.......:|  ::....||.|.....:.|   |..|..:|
  Rat  1102 DLTKTVERLQKERRMMLSRQSPRGREEMAAKRLKKEILHPNSGNANAFSETLGAKLYHPHTFTDS 1166

  Fly   771 HIPAATESQALKEAQNKYRL------------------------LEADYKTLHDKRLQDLKTLQS 811
            ||     |:.|:|   .|||                        ||:..|.:.|.....:.:|::
  Rat  1167 HI-----SEVLEE---NYRLRSELEGLTLEREKLKMESEAAVCQLESSMKRVKDDAAAHIASLKA 1223

  Fly   812 AHERELAS--CNETV---------------------------------------------RILQQ 829
            |||||:..  |...|                                             .|||:
  Rat  1224 AHEREIEKLLCQNAVENSSSRVAELNRKIATQEVLLKHFQGQVNELQGKQESLSLSQVREEILQK 1288

  Fly   830 RLNEREEALTTQKRRKVP--VDYYALKAKVSLLERRHSEREERLHMLVE 876
            ::.:..|.|...|....|  ..:..|:.|:..:|.||.:||:.|..:::
  Rat  1289 QITKLLEELKEAKENHTPEMKHFMGLERKIKQMEMRHKQREQELQQIIQ 1337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42699	NP_572263.2	FlaC	<316..423	CDD:225888	26/117 (22%)
Cep162	NP_001263989.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..235
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..342
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..586		35/161 (22%)
		Smc	<613..1300	CDD:224117	151/818 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28K8R
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto98599
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR34031
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.000