DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt4 and SRT2

DIOPT Version :9

Sequence 1:	NP_572241.2	Gene:	Sirt4 / 31480	FlyBaseID:	FBgn0029783	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_001078550.1	Gene:	SRT2 / 830782	AraportID:	AT5G09230	Length:	376	Species:	Arabidopsis thaliana

Alignment Length:	300	Identity:	126/300 - (42%)
Similarity:	180/300 - (60%)	Gaps:	19/300 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QEYVPHHKPVVEDDIKRLEDFLLSKPNVLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHME 85
            ::.||...|...:||.:|.........:.:|||||:|||.|||||||.. |.|: |..||:.|.|
plant    71 RKIVPDADPPNMEDIHKLYRLFEQSSRLTILTGAGVSTECGIPDYRSPN-GAYS-SGFKPITHQE 133

  Fly    86 FVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVE 150
            |.:||..|:|||||::.||.:|:|.||...|.|||..|:..|:..::||||||||.:||| :.:|
plant   134 FTRSSRARRRYWARSYAGWRRFTAAQPGPAHTALASLEKAGRINFMITQNVDRLHHRAGS-DPLE 197

  Fly   151 VHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDMI---------------RPDGDVEIPL 200
            :||:.|.|.||.|.:...|..||..|.::||.:.:|.:.|               |||||:||..
plant   198 LHGTVYTVMCLECGFSFPRDLFQDQLKAINPKWAEAIESIDHGDPGSEKSFGMKQRPDGDIEIDE 262

  Fly   201 EY-IENFRIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVL 264
            :: .|.|.||.|.:|.|.|||:::||||::|:.|..|...:...||..|||||||:..|.:|:..
plant   263 KFWEEGFHIPVCEKCKGVLKPDVIFFGDNIPKERATQAMEVAKQSDAFLVLGSSLMTMSAFRLCR 327

  Fly   265 QTKDLKLPVGIVNIGETRADHLADIKISAKCGDVIPKLFD 304
            ...:......||||||||||.:..:||:|:.|:::.::.|
plant   328 AAHEAGAMTAIVNIGETRADDIVPLKINARVGEILHRVLD 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	120/276 (43%)
SRT2	NP_001078550.1	SIRT4	88..362	CDD:238700	120/276 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	193	1.000	Domainoid score	I921
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8164
Inparanoid	1	1.050	239	1.000	Inparanoid score	I1087
OMA	1	1.010	-	-		QHG56570
OrthoDB	1	1.010	-	-		D1407693at2759
OrthoFinder	1	1.000	-	-		FOG0005863
OrthoInspector	1	1.000	-	-		oto3272
orthoMCL	1	0.900	-	-		OOG6_103918
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840