DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt4 and Sirt2

DIOPT Version :9

Sequence 1:	NP_572241.2	Gene:	Sirt4 / 31480	FlyBaseID:	FBgn0029783	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_071877.3	Gene:	Sirt2 / 64383	MGIID:	1927664	Length:	389	Species:	Mus musculus

Alignment Length:	251	Identity:	67/251 - (26%)
Similarity:	106/251 - (42%)	Gaps:	56/251 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VLVLTGAGISTESGIPDYRSEGVGLYA--RSNHKP----VQHMEFVKSS-----AVRKRYWARNF 101
            |:.|.||||||.:||||:||...||||  ...|.|    :..:.:.|..     |:.|..:...|
Mouse    79 VICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQF 143

  Fly   102 VGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAG--SRNVVEVHGSGYVVKCL--S 162
                     :|...|:.:...:.:..:....|||:|.|...||  .:::||.||:.|...|:  |
Mouse   144 ---------KPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTS 199

  Fly   163 C--EYRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFF 225
            |  ||.:...:                             |.|.:...|.|.||...:||:||||
Mouse   200 CRKEYTMGWMK-----------------------------EKIFSEATPRCEQCQSVVKPDIVFF 235

  Fly   226 GDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVNIGET 281
            |:::|......:.......|.|:::|:||.| ..:..::....|..|..::|..:|
Mouse   236 GENLPSRFFSCMQSDFSKVDLLIIMGTSLQV-QPFASLISKAPLATPRLLINKEKT 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	67/251 (27%)
Sirt2	NP_071877.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Nuclear export signal. /evidence=ECO:0000250	41..51
		SIRT1	77..331	CDD:238699	67/251 (27%)
		Peptide inhibitor binding. /evidence=ECO:0000250	116..120		0/3 (0%)
		Peptide inhibitor binding. /evidence=ECO:0000250	232..301		16/60 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..389
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810