DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sirt4 and Sirt2

DIOPT Version :10

Sequence 1:NP_572241.2 Gene:Sirt4 / 31480 FlyBaseID:FBgn0029783 Length:312 Species:Drosophila melanogaster
Sequence 2:NP_071877.3 Gene:Sirt2 / 64383 MGIID:1927664 Length:389 Species:Mus musculus


Alignment Length:251 Identity:67/251 - (26%)
Similarity:106/251 - (42%) Gaps:56/251 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 VLVLTGAGISTESGIPDYRSEGVGLYA--RSNHKP----VQHMEFVKSS-----AVRKRYWARNF 101
            |:.|.||||||.:||||:||...||||  ...|.|    :..:.:.|..     |:.|..:...|
Mouse    79 VICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQF 143

  Fly   102 VGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAG--SRNVVEVHGSGYVVKCL--S 162
                     :|...|:.:...:.:..:....|||:|.|...||  .:::||.||:.|...|:  |
Mouse   144 ---------KPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTS 199

  Fly   163 C--EYRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFF 225
            |  ||.:...:                             |.|.:...|.|.||...:||:||||
Mouse   200 CRKEYTMGWMK-----------------------------EKIFSEATPRCEQCQSVVKPDIVFF 235

  Fly   226 GDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVNIGET 281
            |:::|......:.......|.|:::|:||.| ..:..::....|..|..::|..:|
Mouse   236 GENLPSRFFSCMQSDFSKVDLLIIMGTSLQV-QPFASLISKAPLATPRLLINKEKT 290

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sirt4NP_572241.2 SIRT4 38..299 CDD:238700 67/251 (27%)
Sirt2NP_071877.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34
Nuclear export signal. /evidence=ECO:0000250 41..51
SIRT1 77..331 CDD:238699 67/251 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..389
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.