DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sirt4 and Sirt6

DIOPT Version :9

Sequence 1:	NP_572241.2	Gene:	Sirt4 / 31480	FlyBaseID:	FBgn0029783	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_001365873.1	Gene:	Sirt6 / 50721	MGIID:	1354161	Length:	334	Species:	Mus musculus

Alignment Length:	288	Identity:	74/288 - (25%)
Similarity:	122/288 - (42%)	Gaps:	68/288 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VEDDIKRLEDFLLSKPNVLVLTGAGISTESGIPDYRS-EGVGLYARSNHKPVQHMEFVKSSAVRK 94
            :|..:..|...:....:|:..|||||||.|||||:|. .||
Mouse    30 LERKVWELARLMWQSSSVVFHTGAGISTASGIPDFRGPHGV------------------------ 70

  Fly    95 RYWARNFVGW-PKFSAT----QPNATHHALARFEREERVQAVVTQNVDRLHTKAG--SRNVVEVH 152
              |.....|. |||..|    :|:.||.||.:.||...:..:|:||||.||.::|  ...:.|:|
Mouse    71 --WTMEERGLAPKFDTTFENARPSKTHMALVQLERMGFLSFLVSQNVDGLHVRSGFPRDKLAELH 133

  Fly   153 GSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRIPECT----- 212
            |:.:|.:|..|:.:..|   .:::.::.         ::..|.:              ||
Mouse   134 GNMFVEECPKCKTQYVR---DTVVGTMG---------LKATGRL--------------CTVAKTR 172

  Fly   213 ---QCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVG 274
               .|.|:|:..|:.:.||:|...:.........:|..:.||:||.:.....:.|.||.....:.
Mouse   173 GLRACRGELRDTILDWEDSLPDRDLMLADEASRTADLSVTLGTSLQIRPSGNLPLATKRRGGRLV 237

  Fly   275 IVNIGETRADHLADIKISAKCGDVIPKL 302
            |||:..|:.|..||::|.....:|:.:|
Mouse   238 IVNLQPTKHDRQADLRIHGYVDEVMCRL 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt4	NP_572241.2	SIRT4	38..299	CDD:238700	71/276 (26%)
Sirt6	NP_001365873.1	SIRT7	45..257	CDD:238701	70/263 (27%)
Sirt6	NP_001365873.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810