Protein Alignment SK and kcnn2

DIOPT Version :10

• Sequence 1: NP_001284887.1
• Gene: SK / 31456
• FlyBaseID: FBgn0029761
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: XP_073770716.1
• Gene: kcnn2 / 564698
• ZFINID: ZDB-GENE-091116-41
• Length: 674
• Species: Danio rerio
• Alignment Length: 665
• Identity: 338/665 - (50%)
• Similarity: 445/665 - (66%)
• Gaps: 74/665 - (11%)

  Fly   275 QLQQQYHLQQQQQQHYQLQQHHLHQQQ--------------LQQSQQQVP----PV--LITSSPT 319
            |||..::.:||||||.: .||:..:::              .:.:::..|    |:  |.|.|.:
Zfish     6 QLQNNFYPEQQQQQHCK-YQHYCGREEERSIRHCTCNNSSTCEDARKSQPLHGTPLGTLRTPSVS 69

  Fly   320 NGSRIIRQSSQPESSSTAICCGPHSACVGHAHSHSHTVPNVSLKQLRES------SGDGIAGIAA 378
            :.:|...|.|:...||..      |:...|.|.|.|...:.:.:|:|.|      ..:....||.
Zfish    70 SSTRQGAQYSEFTPSSHG------SSSRHHHHHHHHPHRDHNRQQIRGSPASSHRESNSYTQIAM 128

  Fly   379 DSLRINGG-MRPFKQLRKPASTLSIPGSMKTPSIANREQISSGCNEEAAEALVGIHSDYPRYMEE 442
            .|.|.||| |||...|......|....|...|    .:.:|:.   :|::.|    :..|   |.
Zfish   129 SSCRYNGGVMRPLSNLSSSRRNLHEFDSESQP----LQPVSAA---DASDTL----ASKP---EN 179

  Fly   443 RALT--------------GGNTSRKPSTNSAKHKPNVGYRLGKRKALFEKRKRISDYALVMGMFG 493
            .:.|              ||..|...|.:..|...|:|.:||.|:||||||||:|||||:.||||
Zfish   180 NSSTLMPYATGDGGGGGGGGGCSHSGSKSGKKKNQNIGQKLGHRRALFEKRKRLSDYALIFGMFG 244

  Fly   494 IIVMVIENELSSAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQVRLFMIDNCADDWRI 558
            |:|||||.|| |.|.|.|.|.||.|||.|||:||:||||||:.|||.|:|  |||:||.||||||
Zfish   245 IVVMVIETEL-SWGAYGKESLYSLALKCLISLSTIILLGLIIIYHAREIQ--LFMVDNAADDWRI 306

  Fly   559 AMTWQRISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVPYDVALSLPMFLRLYLICR 623
            |||::||..|.||:.:||||||||.|.|.||.:||.......|: ...|:.||:|||||||||.|
Zfish   307 AMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSKTD-ADVDIILSIPMFLRLYLIAR 370

  Fly   624 VMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERFH 688
            |||||||||||||||||||||:||||||||:|||||||||||||||.:||||||:||:|.|||:|
Zfish   371 VMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFTISLWIIAAWTVRACERYH 435

  Fly   689 D--EEHANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLVAVVSRKLELTR 751
            |  :..:|.|.|||||:||||::|:||:|||||||:|:.:.|||||||||||:||||::|||||:
Zfish   436 DNMDVTSNFLGAMWLISITFLTIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVAKKLELTK 500

  Fly   752 AEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIYALRKVK 816
            |||||||||||||||||:||.|||||||||||||:|:||::::..:||.||||||.||:.||.||
Zfish   501 AEKHVHNFMMDTQLTKRVKNTAANVLRETWLIYKNTKLVRKMDHAKVRKHQRKFLQAIHQLRSVK 565

  Fly   817 MDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPDLLSRC 881
            |:||||.|.||::.|:|||||.:|:::||::.|.:.:|:|:..||.|::::..::::||.|:|:.
Zfish   566 MEQRKLNDQANSLVDLAKTQNVMYDLVSDLNERGEDMEKRIALLETKLETLLSNLQALPGLISQV 630

  Fly   882 LTQHQERIEQRRNFL 896
            ::|      |.|:||
Zfish   631 ISQ------QHRDFL 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	469..581	CDD:460958	78/111 (70%)
		Ion_trans_2	669..748	CDD:462301	53/80 (66%)
		CaMBD	762..836	CDD:460739	50/73 (68%)
kcnn2	XP_073770716.1	None