Protein Alignment SK and Kcnn2

DIOPT Version :10

• Sequence 1: NP_001284887.1
• Gene: SK / 31456
• FlyBaseID: FBgn0029761
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: XP_063133589.1
• Gene: Kcnn2 / 54262
• RGDID: 2963
• Length: 855
• Species: Rattus norvegicus
• Alignment Length: 927
• Identity: 383/927 - (41%)
• Similarity: 511/927 - (55%)
• Gaps: 189/927 - (20%)

  Fly   136 RSSIVPDIEVHEEDQEQHSQQLNATTMATMTNNQQQQQ---PTI-----------------SIMN 180
            :..::|.:.|...::   :::|::|......::.|||:   |||                 |.|.
  Rat     7 KCDVMPIVLVRPTNR---TRRLDSTGAGMGPSSHQQQESPLPTITHCAGCTTAWSPCSFNRSDME 68

  Fly   181 LSLK-------------PGDSHSHSS-------------SPGSHPNLGTSSYQNLASSIPPS-VP 218
            ..|:             |..||.|..             :|..||:    .:.:||...|.| ..
  Rat    69 TPLQFQRGFFPEQPPPPPRSSHLHCQQQQQSQDKPCAPFAPLPHPH----HHPHLAHQQPGSGGS 129

  Fly   219 SRCRACRNCSRRASTTP---------TTLIDRSASRDSVKSAFQQGNLSGSMAICISNSALPQQ- 273
            |.|..|.:|:  :|..|         .:|:.|::|............||||...|..:|....|
  Rat   130 SPCLRCNSCA--SSGAPEAGAGAGDNLSLLLRTSSPGGAFRTRTSSPLSGSSCCCCCSSRRGSQL 192

  Fly   274 -----------QQLQQQYHLQQQQQQHYQLQQHHLHQQQLQQSQQQVPPVLITSSPTNGSRIIRQ 327
                       ..|:|||..|......|    |..|.                         ::.
  Rat   193 NVSELTPSSHASALRQQYAQQPASASLY----HQCHS-------------------------LQP 228

  Fly   328 SSQPESSSTAICCGPHSACVGHAHSHSHTVPNVSLKQLRESSGDGIAGIAADSLRINGG-MRPF- 390
            ::.|..|..::..||.   :.|.|.|.|...:...:.......:....||..|.|.||| |||.
  Rat   229 AASPTGSLGSLGSGPP---LSHHHHHPHPAHHQHHQPQARRESNPFTEIAMSSCRYNGGVMRPLS 290

  Fly   391 ----------------KQLRKPASTLSIPGSMKTPSIANREQISSGCNEEAAEALVGIHSDYPRY 439
                            :.|:.|||.:...|...:||.|      :..:..|.|.:|    ..|.:
  Rat   291 NLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAA------AAASSSAPEIVV----SKPEH 345

  Fly   440 MEERALT------GGNT----------------SRKPSTNSAKHKPNVGYRLGKRKALFEKRKRI 482
            .....|.      ||:|                |...:.:|.|...|:||:||.|:||||||||:
  Rat   346 NNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRL 410

  Fly   483 SDYALVMGMFGIIVMVIENELSSAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQVRLF 547
            |||||:.|||||:|||||.|| |.|.|.|||.||.|||.|||:||:||||||:.|||.|:|  ||
  Rat   411 SDYALIFGMFGIVVMVIETEL-SWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQ--LF 472

  Fly   548 MIDNCADDWRIAMTWQRISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVPYDVALSL 612
            |:||.|||||||||::||..|.||:.:||||||||.|.|.||.:|| .:....|.....|:.||:
  Rat   473 MVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLA-FSYAPSTTTADVDIILSI 536

  Fly   613 PMFLRLYLICRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIA 677
            |||||||||.||||||||||||||||||||||:||||||||:|||||||||||||||.:||||||
  Rat   537 PMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIA 601

  Fly   678 SWTLRQCERFHDEEH--ANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLV 740
            :||:|.|||:||::.  :|.|.|||||:|||||:|:||:|||||||:|:.:.|||||||||||:|
  Rat   602 AWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVV 666

  Fly   741 AVVSRKLELTRAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKF 805
            |||:||||||:|||||||||||||||||:||||||||||||||||:|:|||:::..:||.|||||
  Rat   667 AVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKF 731

  Fly   806 LLAIYALRKVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSIQEH 870
            |.||:.||.|||:||||.|.|||:.|:|||||.:|::|||::.|.:..|:|:..||.|::::...
  Rat   732 LQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGS 796

  Fly   871 MESLPDLLSRCLTQHQERIEQRRNFLHPDTAAVAPIQAPTPQSMFNAAPMLFPHSSVPSSNNAAA 935
            :.:||.|:|:.:.|      |:|:|:.            |....::      .|.:..:..:.::
  Rat   797 IHALPGLISQTIRQ------QQRDFIE------------TQMENYD------KHVTYNAERSRSS 837

  Fly   936 TYHWPTSPILPPISSRT 952
            :....:|...||.||.:
  Rat   838 SRRRRSSSTAPPTSSES 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	469..581	CDD:460958	79/111 (71%)
		Ion_trans_2	669..748	CDD:462301	55/80 (69%)
		CaMBD	762..836	CDD:460739	53/73 (73%)
Kcnn2	XP_063133589.1	None