Protein Alignment SK and Kcnn1

DIOPT Version :10

• Sequence 1: NP_001284887.1
• Gene: SK / 31456
• FlyBaseID: FBgn0029761
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: NP_062186.1
• Gene: Kcnn1 / 54261
• RGDID: 2962
• Length: 536
• Species: Rattus norvegicus
• Alignment Length: 525
• Identity: 296/525 - (56%)
• Similarity: 367/525 - (69%)
• Gaps: 69/525 - (13%)

  Fly   433 HSDYPRYMEERALTGGNTSRKPSTNSAKHKPNVGYRLGKRKALFEKRKRISDYALVMGMFGIIVM 497
            ||......||........|.||        |.|.:|||.|:||||||||:|||||:.|||||:||
  Rat    61 HSQAQEEEEEEEDEDRPGSGKP--------PTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVM 117

  Fly   498 VIENELSSAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQVRLFMIDNCADDWRIAMTW 562
            |.|.|| |.|||||.|..|.|||.|||:||||||||::.|||.|:|  ||::||.||||||||||
  Rat   118 VTETEL-SWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQ--LFLVDNGADDWRIAMTW 179

  Fly   563 QRISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVP------YDVALSLPMFLRLYLI 621
            :|:|.|.|||.:|||||:||.|.|.||.:||       ..:||      .||.||:||||||||:
  Rat   180 ERVSLISLELAVCAIHPVPGHYRFTWTARLA-------FSLVPSAAEADVDVLLSIPMFLRLYLL 237

  Fly   622 CRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCER 686
            .|||||||::||||||||||||||:.||||||.|||||||||||||||.:|.||:|:||:|.|||
  Rat   238 ARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVCER 302

  Fly   687 FHDEEH--ANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLVAVVSRKLEL 749
            :||::.  :|.|.|||||:|||||:|:||:||:||||:|:.:.|||||||||||:||||:|||||
  Rat   303 YHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLEL 367

  Fly   750 TRAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIY---A 811
            |:|||||||||||||||||:||||||||||||||||||||||:.:..|||.||||||.||:   .
  Rat   368 TKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQRKFLQAIHQAQK 432

  Fly   812 LRKVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPD 876
            ||.||::|.|:.|.|||:.|:||.|:..||::|::.::|:.:|.||..||.::..:...:::||.
  Rat   433 LRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPS 497

  Fly   877 LLSRCLTQHQERIEQRRNFLHPDTAAVAPIQAPTPQSMFNAAPMLFPHSSVPSSNNAAA---TYH 938
            |:::                     |:.|:..|.|.               ||....||   ..|
  Rat   498 LIAQ---------------------AICPLPPPWPG---------------PSHLTTAAQSPQSH 526

  Fly   939 W-PTS 942
            | ||:
  Rat   527 WLPTT 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	469..581	CDD:460958	79/111 (71%)
		Ion_trans_2	669..748	CDD:462301	52/80 (65%)
		CaMBD	762..836	CDD:460739	53/76 (70%)
Kcnn1	NP_062186.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..90		10/36 (28%)
		SK_channel	89..198	CDD:460958	79/111 (71%)
		Ion_trans_2	287..366	CDD:462301	51/78 (65%)
		Calmodulin-binding. /evidence=ECO:0000250	380..459		54/78 (69%)
		CaMBD	380..457	CDD:460739	53/76 (70%)
		EnvC	413..>503	CDD:443969	37/110 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	514..536		7/18 (39%)