Protein Alignment SK and Kcnn4

DIOPT Version :10

• Sequence 1: NP_001284887.1
• Gene: SK / 31456
• FlyBaseID: FBgn0029761
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: NP_032459.3
• Gene: Kcnn4 / 16534
• MGIID: 1277957
• Length: 425
• Species: Mus musculus
• Alignment Length: 435
• Identity: 179/435 - (41%)
• Similarity: 252/435 - (57%)
• Gaps: 47/435 - (10%)

  Fly   469 LGKRKALFEKRKRISDYALVMGMFGIIVMVIENE-LSSAGVYTKASFYSTALKTLISVSTVILLG 532
            |.:||.|.|:.||::.:|||:...||.:||:..| |...|  .|...|...:|.||::||..||.
Mouse    12 LRRRKRLLEQEKRVAGWALVLAGTGIGLMVLHAEMLWFLG--CKWVLYLLLVKCLITLSTAFLLC 74

  Fly   533 LIVAYHALEVQVRLFMIDNCADDWRIAMTWQRISQIGLELFICAIHPIP---------GEYYFQW 588
            |||.:||.|||  |||.||...|||:|:|.::::||.|||.:|.:||:|         ||
Mouse    75 LIVVFHAKEVQ--LFMTDNGLRDWRVALTRRQVAQILLELLVCGVHPVPLRSPHCALAGE----- 132

  Fly   589 TTKLANKNKTIGTEMVPY-------DVALSLPMFLRLYLICRVMLLHSKLFTDASSRSIGALNRI 646
                       .|:..|:       :..|||.|.|||||:.|.:||.|.:..:||.|||||||::
Mouse   133 -----------ATDAQPWPGFLGEGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQV 186

  Fly   647 NFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERFHDEEHANLLNAMWLIAITFLSVGF 711
            .|...||.|..|...||.:||...:.||:..:|.|...||.......:|.:.:|||.||||::|:
Mouse   187 RFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLTDTLWLIPITFLTIGY 251

  Fly   712 GDIVPNTYCGRGIAVSTGIMGAGCTALLVAVVSRKLELTRAEKHVHNFMMDTQLTKRLKNAAANV 776
            ||:||.|..|:.:.:.||:||..|||||||||:||||..:|||||||||||....|.:|.:||.:
Mouse   252 GDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIHYAKEMKESAARL 316

  Fly   777 LRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIYALRKVKMDQRKLMDNANTITDMAKTQNTVYE 841
            |:|.|:.|||||   |.:....|.||||.|.||:..|:|::..|||.:..|::.|::|....:.:
Mouse   317 LQEAWMYYKHTR---RKDSRAARRHQRKMLAAIHTFRQVRLKHRKLREQVNSMVDISKMHMILCD 378

  Fly   842 IISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPDLLSRCLTQHQ 886
            :...:||...|:|:|:..|..|       :::|.:||...|.|.|
Mouse   379 LQLGLSSSHRALEKRIDGLAGK-------LDALTELLGTALQQQQ 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	469..581	CDD:460958	52/112 (46%)
		Ion_trans_2	669..748	CDD:462301	36/78 (46%)
		CaMBD	762..836	CDD:460739	30/73 (41%)
Kcnn4	NP_032459.3	SK_channel	12..121	CDD:460958	52/112 (46%)
		Ion_trans_2	<235..288	CDD:462301	30/52 (58%)
		Calmodulin-binding. /evidence=ECO:0000250	284..345		34/63 (54%)
		CaMBD	302..373	CDD:460739	30/73 (41%)