Protein Alignment SK and Kcnn2

DIOPT Version :10

• Sequence 1: NP_001284887.1
• Gene: SK / 31456
• FlyBaseID: FBgn0029761
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: XP_030106191.1
• Gene: Kcnn2 / 140492
• MGIID: 2153182
• Length: 852
• Species: Mus musculus
• Alignment Length: 920
• Identity: 384/920 - (41%)
• Similarity: 513/920 - (55%)
• Gaps: 178/920 - (19%)

  Fly   136 RSSIVPDIEVHEEDQEQHSQQLNATTMATMTNNQQQQQ---PTI-----------------SIMN 180
            :..::|.:.|...::   :::|::|......::.|||:   |||                 |.|.
Mouse     7 KCDVMPIVLVRPTNR---TRRLDSTGAGMGPSSHQQQESPLPTITHCAGCTTAWSPCSFNSSDME 68

  Fly   181 LSLK-------------PGDSHSHSS-------------SPGSHPNLGTSSYQNLASSIPPS-VP 218
            ..|:             |..||.|..             :|..||:    .:.:||...|.| ..
Mouse    69 TPLQFQRGFFPEQPPPPPRSSHLHCQQQQQSQDKPCAPFAPLPHPH----HHPHLAHQQPGSGGS 129

  Fly   219 SRCRACRNCSRRASTTPT---------TLIDRSASRDSVKSAFQQGNLSGSMAICISNSALPQQ- 273
            |.|..|.:|:  :|..|.         :|:.|::|............||||...|..:|....|
Mouse   130 SPCLRCNSCA--SSGAPAAGAGAGDNLSLLLRTSSPGGAFRTRTSSPLSGSSCCCCCSSRRGSQL 192

  Fly   274 --QQLQQQYHLQQQQQQHYQ-----LQQHHLHQQQLQQSQQQVPPVLITSSPTNGSRIIRQSSQP 331
              .:|....|....:||:.|     .|.|..|.                         ::.::.|
Mouse   193 NVSELTPSSHASALRQQYAQQPASASQYHQCHS-------------------------LQPATSP 232

  Fly   332 ESSSTAICCGPHSACVGHAHSHSHTVPNVSLKQLRESSGDGIAGIAADSLRINGG-MRPF----- 390
            ..|..::..||.   :.|.|.|.|...:...:.......:....||..|.|.||| |||.
Mouse   233 TGSLGSLGSGPP---LSHHHHHPHPAHHQHHQPQARRESNPFTEIAMSSCRYNGGVMRPLSNLSS 294

  Fly   391 ------------KQLRKPASTLSIPGSMKTPSIANREQISSGCNEEAAEALVGIHSDYPRYMEER 443
                        :.|:.|||.:...|...:||.|      :..:..|.|.:|    ..|.:....
Mouse   295 SRRNLQEMDSEAQPLQPPASVVGGGGGASSPSAA------AAASSSAPEIVV----SKPEHNNSN 349

  Fly   444 ALT------GGNT----------SRKPSTNSAKHKPNVGYRLGKRKALFEKRKRISDYALVMGMF 492
            .|.      ||:|          |...:.:|.|...|:||:||.|:||||||||:|||||:.|||
Mouse   350 NLALYGTGGGGSTGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMF 414

  Fly   493 GIIVMVIENELSSAGVYTKASFYSTALKTLISVSTVILLGLIVAYHALEVQVRLFMIDNCADDWR 557
            ||:|||||.|| |.|.|.|||.||.|||.|||:||:||||||:.|||.|:|  |||:||.|||||
Mouse   415 GIVVMVIETEL-SWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQ--LFMVDNGADDWR 476

  Fly   558 IAMTWQRISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVPYDVALSLPMFLRLYLIC 622
            ||||::||..|.||:.:||||||||.|.|.||.:|| .:....|.....|:.||:|||||||||.
Mouse   477 IAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLA-FSYAPSTTTADVDIILSIPMFLRLYLIA 540

  Fly   623 RVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERF 687
            ||||||||||||||||||||||:||||||||:|||||||||||||||.:||||||:||:|.|||:
Mouse   541 RVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERY 605

  Fly   688 HDEEH--ANLLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLVAVVSRKLELT 750
            ||::.  :|.|.|||||:|||||:|:||:|||||||:|:.:.|||||||||||:||||:||||||
Mouse   606 HDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELT 670

  Fly   751 RAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIY---AL 812
            :|||||||||||||||||:||||||||||||||||:|:|||:::..:||.||||||.||:   .|
Mouse   671 KAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQARKL 735

  Fly   813 RKVKMDQRKLMDNANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSIQEHMESLPDL 877
            |.|||:||||.|.|||:.|:|||||.:|::|||::.|.:..|:|:..||.|::::...:.:||.|
Mouse   736 RSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGL 800

  Fly   878 LSRCLTQHQERIEQRRNFLHPDTAAVAPIQAPTPQSMFNAAPMLFPHSSVPSSNNAAATYHWPTS 942
            :|:.:.|      |:|:|:.            |....::      .|.|..:..:.:::....:|
Mouse   801 ISQTIRQ------QQRDFIE------------TQMENYD------KHVSYNAERSRSSSRRRRSS 841

  Fly   943 PILPPISSRT 952
            ...||.||.:
Mouse   842 STAPPTSSES 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	469..581	CDD:460958	79/111 (71%)
		Ion_trans_2	669..748	CDD:462301	55/80 (69%)
		CaMBD	762..836	CDD:460739	53/76 (70%)
Kcnn2	XP_030106191.1	SK_channel	391..500	CDD:460958	79/111 (71%)
		Ion_trans_2	589..668	CDD:462301	54/78 (69%)
		CaMBD	682..760	CDD:198121	54/77 (70%)