Protein Alignment SK and kcnn4

DIOPT Version :10

• Sequence 1: NP_001284887.1
• Gene: SK / 31456
• FlyBaseID: FBgn0029761
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: XP_004916452.1
• Gene: kcnn4 / 101732300
• XenbaseID: XB-GENE-1013002
• Length: 474
• Species: Xenopus tropicalis
• Alignment Length: 433
• Identity: 186/433 - (42%)
• Similarity: 272/433 - (62%)
• Gaps: 24/433 - (5%)

  Fly   448 GNTSRKPSTNSA---KHK-------PNVGYR-LGKRKALFEKRKRISDYALVMGMFGIIVMVIEN 501
            |:...|..|..|   .||       ||...| ..:||.|.|.:|:||.:.:::.:.|||:||:..
 Frog    38 GDMQAKEPTEVAILNSHKVHIVRDDPNENLRKFKRRKGLVETKKKISAWTILVALLGIILMVVHT 102

  Fly   502 ELSSAGVYTKASF--YSTALKTLISVSTVILLGLIVAYHALEVQVRLFMIDNCADDWRIAMTWQR 564
            ||.   .|:|..:  |...:|..||:|||||:.||:|:|..|:|:  ||.||...|||||:..:.
 Frog   103 ELM---WYSKCEWFPYLFLVKCSISISTVILIILIIAFHLKEIQI--FMNDNSLQDWRIAINAKN 162

  Fly   565 ISQIGLELFICAIHPIPGEYYFQWTTKLANKNKTIGTEMVPYDVALSLPMFLRLYLICRVMLLHS 629
            |..|.||:.:|||||.|  |..|...:..|.::.: ..:...|:.||:.||||:||:.|.:||:|
 Frog   163 IGWILLEVVVCAIHPFP--YVLQCVEEQGNNSEEL-EFLSEADIFLSILMFLRVYLLPRTVLLYS 224

  Fly   630 KLFTDASSRSIGALNRINFNTRFVLKTLMTICPGTVLLVFMVSLWIIASWTLRQCERFHDEEHAN 694
            ::..|.|.||||:||:|.|..:||:|.||..|||.|||:..:|||:::||.|..|||.......:
 Frog   225 RVLGDTSYRSIGSLNKIKFQYKFVMKVLMNTCPGKVLLILSISLWVVSSWVLSVCERKKQVPTGD 289

  Fly   695 LLNAMWLIAITFLSVGFGDIVPNTYCGRGIAVSTGIMGAGCTALLVAVVSRKLELTRAEKHVHNF 759
            :.||:|||.||||::|:||:||||.||:.:.:|||:||.|||||:|||.::|||.||||||||.|
 Frog   290 MTNALWLIPITFLTIGYGDMVPNTVCGKLVCLSTGVMGVGCTALIVAVAAQKLEFTRAEKHVHTF 354

  Fly   760 MMDTQLTKRLKNAAANVLRETWLIYKHTRLVKRVNPGRVRTHQRKFLLAIYALRKVKMDQRKLMD 824
            |||.:..|::|.||||||.|.||:::||   |:.:..:.|.|||..|.||:..|:.::..:.|.|
 Frog   355 MMDIRCMKQIKCAAANVLGEAWLLHRHT---KKGDKAQTRQHQRNLLRAIHVFRRSRISHKNLKD 416

  Fly   825 NANTITDMAKTQNTVYEIISDMSSRQDAIEERLTNLEDKMQSI 867
            ..|.:.|::|.|..:.::..:.||....:|:|:..|:.|:..|
 Frog   417 QMNAMVDISKMQMIMEDLDLNFSSSHRELEKRIDQLDKKLDDI 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SK	NP_001284887.1	SK_channel	469..581	CDD:460958	49/113 (43%)
		Ion_trans_2	669..748	CDD:462301	41/78 (53%)
		CaMBD	762..836	CDD:460739	28/73 (38%)
kcnn4	XP_004916452.1	SK_channel	71..179	CDD:460958	49/112 (44%)
		Ion_trans_2	266..343	CDD:462301	41/76 (54%)
		CaMBD	357..428	CDD:460739	28/73 (38%)