Protein Alignment Cdk7 and CDKL2

DIOPT Version :10

• Sequence 1: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: XP_047272338.1
• Gene: CDKL2 / 8999
• HGNCID: 1782
• Length: 582
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 106/300 - (35%)
• Similarity: 169/300 - (56%)
• Gaps: 28/300 - (9%)

  Fly    10 ERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENI 74
            |:|..|..:|||.:..|.|.|:..|.:|||:||..: |.:|..  :.:.|:||||:|::|:|||:
Human     2 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLE-SDDDKM--VKKIAMREIKLLKQLRHENL 63

  Fly    75 IGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKII---LTQANIKAYAIMTLKGLEYLHLNWILHR 136
            :.|::|..:.....|||:|:|   ..|:.|.::.   |....::.|....:.|:.:.|.:.|:||
Human    64 VNLLEVCKKKKRWYLVFEFVD---HTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHR 125

  Fly   137 DLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGC 201
            |:||.|:||:..|::|:.|||.|::..:|..:||.:|.|||||:||||.|..:||..||:||:||
Human   126 DIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGC 190

  Fly   202 ILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRN--FPGT--------- 255
            ::.|:.:..|..|||||:|||..|...||        :|...|..|..:|  |.|.
Human   191 LVTEMFMGEPLFPGDSDIDQLYHIMMCLG--------NLIPRHQELFNKNPVFAGVRLPEIKERE 247

  Fly   256 PLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYF 295
            ||:..:......:|.|.::...::|.:|..|.|.|...:|
Human   248 PLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	104/298 (35%)
CDKL2	XP_047272338.1	STKc_CDKL2_3	2..287	CDD:270836	105/298 (35%)