Protein Alignment Cdk7 and MAPK7

DIOPT Version :10

• Sequence 1: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: XP_006721620.1
• Gene: MAPK7 / 5598
• HGNCID: 6880
• Length: 822
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 119/367 - (32%)
• Similarity: 185/367 - (50%)
• Gaps: 29/367 - (7%)

  Fly     7 DKTERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQH 71
            |..:.|..:..:|.|.:..|..||..:|.|.||:|||....  |......|| |||:|||:..:|
Human    50 DVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAF--DVVTNAKRT-LRELKILKHFKH 111

  Fly    72 ENIIGLVDV------FGQLSNVS------LVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKG 124
            :|||.:.|:      :|:..:|.      :|.|.|::||..||..:: .||..:::.:....|:|
Human   112 DNIIAIKDILRPTVPYGEFKSVPYGVPGYVVLDLMESDLHQIIHSSQ-PLTLEHVRYFLYQLLRG 175

  Fly   125 LEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSF-GSP---NRIYTHHVVTRWYRSPELLF 185
            |:|:|...::||||||:|||||.:..|||||||:|:.. .||   ....|.:|.|||||:|||:.
Human   176 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELML 240

  Fly   186 GARQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEA--EWPHLSKLHDYLQ 248
            ...:|...:|:|:||||..|::.|....||.:.:.||..|...||||:.|  :.....::..|:|
Human   241 SLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQ 305

  Fly   249 FRNFP---GTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMP 310
              :.|   ..|.:.::..|....:.|:.|:....|..|:|...||..|:.|....|...|....|
Human   306 --SLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPP 368

  Fly   311 SAILAAKEGANPQTGDTKPALKRKLVETTVRGNGLAQKKRLQ 352
            ......:|....:.  .|.|:..::.:...|..|:.|:.|.|
Human   369 FDFAFDREALTRER--IKEAIVAEIEDFHARREGIRQQIRFQ 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	109/317 (34%)
MAPK7	XP_006721620.1	STKc_ERK5	49..390	CDD:270842	114/347 (33%)