Protein Alignment Cdk7 and MAPK4

DIOPT Version :10

• Sequence 1: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_002738.2
• Gene: MAPK4 / 5596
• HGNCID: 6878
• Length: 587
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 104/330 - (31%)
• Similarity: 160/330 - (48%)
• Gaps: 45/330 - (13%)

  Fly    11 RYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENII 75
            |:.....||.|....|..|.|:...:.||||||   :..|||.  .:.|||||||::.|.|:||:
Human    19 RFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKI---ALSDARS--MKHALREIKIIRRLDHDNIV 78

  Fly    76 GLVDVFG-----------QLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLH 129
            .:.:|.|           :.|...:|.::|:|||..:::..  .|.:.:.|.:....|:||:|:|
Human    79 KVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQG--TLAEEHAKLFMYQLLRGLKYIH 141

  Fly   130 LNWILHRDLKPNNLLVNS-DGILKIGDFGLAKSFGSPNRIYTHH------VVTRWYRSPELLFGA 187
            ...:|||||||.|:.::: |.:|||||||||:..   ::.|:|.      :||:|||||.||...
Human   142 SANVLHRDLKPANIFISTEDLVLKIGDFGLARIV---DQHYSHKGYLSEGLVTKWYRSPRLLLSP 203

  Fly   188 RQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNF 252
            ..|...:||||.||||||::.......|..:|:|:..|..|:....|.:...|        .|..
Human   204 NNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDEL--------LRVM 260

  Fly   253 PG---------TPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLP 308
            |.         .||..:.....::.|..::::...||:.|::....|..||.:....|...|...
Human   261 PSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQ 325

  Fly   309 MPSAI 313
            .|..|
Human   326 HPFRI 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	102/323 (32%)
MAPK4	NP_002738.2	STKc_MAPK4_6	14..351	CDD:143359	104/330 (32%)
		SEG motif	186..188		0/1 (0%)
		FRIEDE motif	328..333		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	373..413
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	499..534