Protein Alignment Cdk7 and MAPK3

DIOPT Version :10

• Sequence 1: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_002737.2
• Gene: MAPK3 / 5595
• HGNCID: 6877
• Length: 379
• Species: Homo sapiens
• Alignment Length: 349
• Identity: 121/349 - (34%)
• Similarity: 182/349 - (52%)
• Gaps: 29/349 - (8%)

  Fly     7 DKTERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQH 71
            |...||.:|.::|||.:..|..|.|.|....||:|||   |..:.:....|| ||||:||...:|
Human    37 DVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI---SPFEHQTYCQRT-LREIQILLRFRH 97

  Fly    72 ENIIGLVDV-----FGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLN 131
            ||:||:.|:     ...:.:|.:|.|.|:|||..::|..:  |:..:|..:....|:||:|:|..
Human    98 ENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ--LSNDHICYFLYQILRGLKYIHSA 160

  Fly   132 WILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNR----IYTHHVVTRWYRSPELLFGARQYGT 192
            .:|||||||:|||:|:...|||.|||||: ...|..    ..|.:|.|||||:||::..::.|..
Human   161 NVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTK 224

  Fly   193 GVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHL--SKLHDYLQFRNFPG- 254
            .:|:|:|||||||::...|..||...||||..|...||:|::.:...:  .|..:|||  :.|.
Human   225 SIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ--SLPSK 287

  Fly   255 --TPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPSAILAAK 317
              .....:|..:.:..:.|:.|:...||.:|::..|||:.||......||..|....|.......
Human   288 TKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMEL 352

  Fly   318 EGANPQTGDTKPALKRKLVETTVR 341
            :..      .|..||..:.:.|.|
Human   353 DDL------PKERLKELIFQETAR 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	114/310 (37%)
MAPK3	NP_002737.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		STKc_ERK1_2_like	36..370	CDD:270839	120/347 (35%)
		TXY	202..204		1/1 (100%)