Protein Alignment Cdk7 and MAK

DIOPT Version :10

• Sequence 1: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_001229886.1
• Gene: MAK / 4117
• HGNCID: 6816
• Length: 648
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 112/330 - (33%)
• Similarity: 184/330 - (55%)
• Gaps: 25/330 - (7%)

  Fly    11 RYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKG--SREDARDGINRTALREIKILQELQHEN 73
            ||..:..||:|.:.:|...:...:.::||:|::|:.  |.::..:      |||:|.|::|.|.|
Human     3 RYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMN------LREVKSLKKLNHAN 61

  Fly    74 IIGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDL 138
            :|.|.:|..:..::..:|::|..:|..::||...:..::.|:......|:||.::|.:...|||:
Human    62 VIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDM 126

  Fly   139 KPNNLLVNSDGILKIGDFGLAKSFGS--PNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGC 201
            ||.|||.....::||.|||||:...|  |   ||.:|.|||||:||:|..:..|.:.:|:||||.
Human   127 KPENLLCMGPELVKIADFGLARELRSQPP---YTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGS 188

  Fly   202 ILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPGTPLDNIFTA--- 263
            |:|||.:..|..||.|::|::.:|...||||.:::||...:|...:.|| ||.....|:.|.
Human   189 IMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFR-FPQCVPINLKTLIPN 252

  Fly   264 AGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPSAILAAKEGANPQTG--D 326
            |.|:.|.||..:...:|.:|.:..:||..|||      .||..|...|..|.:|:..|.|..  :
Human   253 ASNEAIQLMTEMLNWDPKKRPTASQALKHPYF------QVGQVLGPSSNHLESKQSLNKQLQPLE 311

  Fly   327 TKPAL 331
            :||:|
Human   312 SKPSL 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	103/303 (34%)
MAK	NP_001229886.1	STKc_MAK_like	4..284	CDD:270824	98/289 (34%)