Protein Alignment Cdk7 and Cdkl3

DIOPT Version :10

• Sequence 1: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: XP_006532830.1
• Gene: Cdkl3 / 213084
• MGIID: 2388268
• Length: 638
• Species: Mus musculus
• Alignment Length: 360
• Identity: 117/360 - (32%)
• Similarity: 177/360 - (49%)
• Gaps: 46/360 - (12%)

  Fly    10 ERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENI 74
            |.|..|..:|||.:.||.|.:...|.:|||:|..    .|.....:|:.|.||||.|::.:|||:
Mouse     2 EMYETLGKVGEGSYGTVMKCKHKDTGRIVAIKIF----YEKPEKSVNKIATREIKFLKQFRHENL 62

  Fly    75 IGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLK 139
            :.|::||.|...:.|||:|:|..:...::.....|....::.|....|:.:||||.|.|:|||:|
Mouse    63 VNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNIIHRDIK 127

  Fly   140 PNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILA 204
            |.|:||:..||.|:.|||.|::..:|..:||.:|.|||||:|||:.....||..||:||:||::.
Mouse   128 PENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTSYGKPVDIWALGCMII 192

  Fly   205 ELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKL----------------HDYLQFRNFP 253
            |:....||:|..||||.|.:|...:|..|    |||..:                |.....:.:|
Mouse   193 EMATGHPFLPSSSDLDLLHKIVLKVGNLT----PHLHNIFSKSPIFAGVVLPQVQHPKTARKKYP 253

  Fly   254 GTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFA-----NKPAPTVGPKLPMPSAI 313
              .|:.:..    |::|...::   :|..|.|..:.|...||.     .|..|.:..||...:.:
Mouse   254 --KLNGLLA----DIVHACLQI---DPAERTSSTDLLRHDYFTRDGFIEKFIPELRAKLLQEAKV 309

  Fly   314 ---LAAKEG--ANPQTGDTKPALKRKLVETTVRGN 343
               :..||.  .|....|.|   |.....|.:.||
Mouse   310 NSFIKPKENFKENEPVRDEK---KSVFTNTLLYGN 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	106/317 (33%)
Cdkl3	XP_006532830.1	Protein Kinases, catalytic domain	2..286	CDD:473864	102/300 (34%)