Protein Alignment Cdk7 and cdk-8

DIOPT Version :10

• Sequence 1: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_492357.2
• Gene: cdk-8 / 172677
• WormBaseID: WBGene00000409
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 369
• Identity: 122/369 - (33%)
• Similarity: 181/369 - (49%)
• Gaps: 78/369 - (21%)

  Fly     8 KTERYAKLSF------LGEGQFATVYKA-----RDTVTNQIVAVKKIKKGSREDARDGINRTALR 61
            :.||...|.:      :|.|.:..||||     .....|:..|:|.|:       ..|.:.:|.|
 Worm    16 RRERVEDLFYFENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMIE-------GQGFSMSACR 73

  Fly    62 EIKILQELQHENIIGLVDVFGQLSN---VSLVFDFMDTDLEVIIKDNK--------IILTQANIK 115
            ||.:.:||:|.|:|.|..||  |:|   |.|:.|:.:.||..:||.::        |::.:..:|
 Worm    74 EIALFRELRHPNLICLQRVF--LTNEKKVWLLLDYAEHDLWHVIKHHRTAKSKKVPIMVPRNMVK 136

  Fly   116 AYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSD------GILKIGDFGLAKSFGSPNRIYTH--- 171
            ......|.|:.|||.||:|||||||.|:|:..|      |.:||.|.|.::.:.:|.:....
 Worm   137 NILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDP 201

  Fly   172 HVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVP-FMPGDSDL--------DQLTRIFS 227
            .|||.|||:||||.||:.|...:|:||:|||.|||:...| |...:.|:        ||:.|||.
 Worm   202 VVVTFWYRAPELLLGAKHYTKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFH 266

  Fly   228 TLGTPTEAEWPHLSKLHDYLQF----RNFPGTPLDNIFTAAGNDL---------------IHLMQ 273
            .||.|::|:||.:.|:.|:.:.    || .|||:...    .|.|               ..|:.
 Worm   267 LLGYPSDADWPDMKKMPDHQRLLSDARN-EGTPIQTF----PNSLHRYFDKWKINSQSSPYRLLV 326

  Fly   274 RLFAMNPLRRVSCREALSMPYFANKPAP-----TVGPKLPMPSA 312
            :|..::|.:||||.||::..||.....|     .|..|.|:|.|
 Worm   327 KLLTVDPTKRVSCEEAMNDIYFRKMERPPRETDDVFNKYPIPYA 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	118/360 (33%)
cdk-8	NP_492357.2	STKc_CDK8_like	26..348	CDD:270834	111/335 (33%)
		Med15	<423..>566	CDD:312941