Protein Alignment Cdk7 and cdk12

DIOPT Version :10

• Sequence 1: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: XP_012826946.1
• Gene: cdk12 / 100038049
• XenbaseID: XB-GENE-493308
• Length: 1466
• Species: Xenopus tropicalis
• Alignment Length: 363
• Identity: 109/363 - (30%)
• Similarity: 190/363 - (52%)
• Gaps: 31/363 - (8%)

  Fly    10 ERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENI 74
            :::..:..:|||.:..||||:|..|.::||:||::   .::.::|...||:||||||::|.|:::
 Frog   708 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVR---LDNEKEGFPITAIREIKILRQLIHKSV 769

  Fly    75 IGLVDVFGQLSNV----------SLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLH 129
            :.:.::.....:.          .|||::||.||..:::...:..::.:||::....::||||.|
 Frog   770 VNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCH 834

  Fly   130 LNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGS-PNRIYTHHVVTRWYRSPELLFGARQYGTG 193
            ....||||:|.:|:|:|:.|.:|:.|||||:.:.| .:|.||:.|:|.|||.||||.|..:|...
 Frog   835 KKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPA 899

  Fly   194 VDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDY------LQFRNF 252
            :|:|:.||||.||..:.|....:.:|.||..|....|:|..|.||.:.||..:      .|:|.
 Frog   900 IDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRR- 963

  Fly   253 PGTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVG-PKLPM---PSAI 313
               .|...|:......:.|:..:..::|.:|.:..:.|...:..:.....:. |.||.   ...:
 Frog   964 ---RLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHEL 1025

  Fly   314 LAAKEGANPQTG---DTKPALKRKLVETTVRGNGLAQK 348
            .:.|.....|:|   :..||:|....|:.....|.|.|
 Frog  1026 WSKKRRRQRQSGIVLEEPPAIKAPRKESVSVPGGDAMK 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	97/314 (31%)
cdk12	XP_012826946.1	STKc_CDK12	702..1003	CDD:270847	96/301 (32%)