DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ovo and AgaP_AGAP011963

DIOPT Version :9

Sequence 1:	NP_001162673.1	Gene:	ovo / 31429	FlyBaseID:	FBgn0003028	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	XP_552275.3	Gene:	AgaP_AGAP011963 / 3291462	VectorBaseID:	AGAP011963	Length:	983	Species:	Anopheles gambiae

Alignment Length:	797	Identity:	138/797 - (17%)
Similarity:	240/797 - (30%)	Gaps:	276/797 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   722 EDAIMSDLASSGQCPNGAVDPLQFTATLMLSSQTDHLLEQLSDAVDLSSFLQRSCVDDEESTSPR 786
            ::..:||..|.....||:.:|                    :|.|..|..|::        ||.:
Mosquito     4 KEPTVSDKPSQPDATNGSDEP--------------------ADTVAQSGELKK--------TSKK 40

  Fly   787 QDFELVST--------------PSLTPDSVTPVEQHNTNTTQLDVLHENLLTQLTHNIVRGGSNQ 837
            :.:..|::              |..||....|||:.|..:....|:..        ......||.
Mosquito    41 KGYISVASLFAPVKTARKEQQAPQQTPKQEPPVEESNDESAAAPVVGS--------ETTESASND 97

  Fly   838 QQQHHQQHGVQQQQQQQHSVQQQQQHNVQQ-----QHGVQQQHVQQQPPPSYQHATRGLMMQ--- 894
            |   |||......:......:...::..:|     |..|...|..........:......:|
Mosquito    98 Q---HQQLPTNVAEVSASVAEDVAENKTEQSVSSPQPAVDTAHDDMMEVNGLSNLPEATKVQPVV 159

  Fly   895 ---QQPQHGGYQ---------QQAAIMSQQQQQL-------------------LSQQQQQSHHQQ 928
               :.|:..|.:         :..|..|..::.:                   |.:....|....
Mosquito   160 LPAEVPKESGREGSVASGDSGESCASSSSTEEAVGVAIEVTKQSTAGPVGVDTLKESSPASDSGI 224

  Fly   929 QQQQQHAAAYQQHNI-------------YA-----QQQQQQQQQHHQQQQQQQHHHFHHQQQQQP 975
            :...:........::             :|     :.:..||....:.|||||......:::.:|
Mosquito   225 ESVNESGTPAASSSVPKRPRGRPKSTVSFAGASAKEDKPSQQPDQAKLQQQQQQPLVKEEKELKP 289

  Fly   976 QPQSHHSHHHG-------HGHDNSNMSL------------------PSPTAAAAAAAAAAAAAAA 1015
            :|....|.|:.       .|.:....::                  ||..|..||.:|.....||
Mosquito   290 RPARRKSIHNASLASEKEDGAEEEESAVVATPARTAGKRAVRTARKPSVKAKEAAESAEVEQQAA 354

  Fly  1016 AAAHLQRPMSSSSSSGGTNSS----------------------------------NSSGGSSNSP 1046
            |.|......:|:....||..|                                  .||....:||
Mosquito   355 AEAVAVAVATSAGGEAGTKCSKCELCFKTELWYRKHLINVHGMEPEEVTRLLLAEGSSESKGSSP 419

  Fly  1047 LLDANAAAAAAAALL-----DTKPLIQSLGLPPDLQLEFVNGGHGIKNPLAVENAHGGHH----- 1101
            .:...||||...|:|     :|...:.::|       |.|.....:    |.|:...||.
Mosquito   420 AVPEVAAAAPEPAILTNGGDETTKQVSTVG-------ETVEAAAAV----ADESLQNGHSDEVAQ 473

  Fly  1102 --RIRNIDCIDDLSKHGHHSQHQQQQGSPQQQNMQQSV--------------------------- 1137
              .:..:..:.........|..::::.:|..:..:.||
Mosquito   474 TTNLSPVAAVPSKLAQTSPSTGRKRKSTPYHEEEEPSVPTSTDALAGSNNSEPALPVKELVVLPP 538

  Fly  1138 ----------QQQSVQQQQS----LQQQQQQQHHQHHSNSSASSNASSH--------------GS 1174
                      |:.:.::.:|    |...||....:..|.:..::.|:..              .|
Mosquito   539 AAKVKVEHRAQKATTEETESPPTELAPGQQLAKRRKSSITPIATEATKQEKPDPDDPDKLTPFES 603

  Fly  1175 AEALCMGSSGGANEDSSSGNNKFVCRVCMKTFSLQRLLNRHM-KCHSDIKRYLCTFCGKGFNDTF 1238
            |:...:       |...:|...:.|.:|...|:.:..:..|: ..|:.|||..|.:||:.|..|.
Mosquito   604 AKVTVL-------ESEMTGETHYTCTICGGQFTGKATIKEHLDTVHAAIKRRSCEYCGRTFLQTG 661

  Fly  1239 DLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCQKVHSVQHQYAYKERRAKMYVCEECG----- 1298
            ||.||.|.|||.||:||.:.|.||....|.:.|   .|..:|.   ::...|.:||::||
Mosquito   662 DLTRHVRIHTGQRPFKCPVVECSFAFISSGDLH---KHVRRHN---QQPMPKPHVCDQCGKDFER 720

  Fly  1299 ----------HTTCEPE 1305
                      |...||:
Mosquito   721 SYDLKRHKTMHAKSEPD 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ovo	NP_001162673.1	C2H2 Zn finger	1199..1219	CDD:275368	4/20 (20%)
		zf-H2C2_2	1212..1235	CDD:290200	8/23 (35%)
		C2H2 Zn finger	1227..1247	CDD:275368	10/19 (53%)
		zf-H2C2_2	1239..1264	CDD:290200	15/24 (63%)
		C2H2 Zn finger	1255..1276	CDD:275368	6/20 (30%)
AgaP_AGAP011963	XP_552275.3	C2H2 Zn finger	711..731	CDD:275368	3/19 (16%)
		zf-C2H2	742..763	CDD:278523
		C2H2 Zn finger	743..763	CDD:275368
		zf-H2C2_2	756..779	CDD:290200
		zf-C2H2	769..791	CDD:278523
		C2H2 Zn finger	771..791	CDD:275368
		C2H2 Zn finger	800..817	CDD:275368
		COG5048	<500..787	CDD:227381	54/251 (22%)
		C2H2 Zn finger	621..642	CDD:275368	4/20 (20%)
		C2H2 Zn finger	650..670	CDD:275368	10/19 (53%)
		zf-H2C2_2	662..689	CDD:290200	15/26 (58%)
		C2H2 Zn finger	678..700	CDD:275368	7/24 (29%)
		zf-C2H2	709..731	CDD:278523	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910