DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ovo and Gfi1b

DIOPT Version :9

Sequence 1:	NP_001162673.1	Gene:	ovo / 31429	FlyBaseID:	FBgn0003028	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	NP_001153878.1	Gene:	Gfi1b / 14582	MGIID:	1276578	Length:	363	Species:	Mus musculus

Alignment Length:	331	Identity:	80/331 - (24%)
Similarity:	118/331 - (35%)	Gaps:	83/331 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   993 NMSLPSPTAAAAAAAAAAAAAAAAAAHLQRPMSSS------SSSGGTNSSNSSGGSSNSPLLDAN 1051
            |.|||.     .|:|.............:.|:|.|      |.|..|.:|:.|...:.:|....:
Mouse    69 NQSLPK-----MASAPEGPLVTPQPQDGESPLSESPPFYKPSFSWDTLASSYSHSYTQTPSTMQS 128

  Fly  1052 AAAAAAAALLDTKPLIQSLGLPPDLQLEFVNG---GHGIKNPLAVENAHG-------GHHRIRNI 1106
            |....:..|..: ||:.|...|.|.:|.:..|   .|.:|........||       .|...|..
Mouse   129 AFLERSVRLYGS-PLVPSTESPLDFRLRYSPGMDTYHCVKCNKVFSTPHGLEVHVRRSHSGTRPF 192

  Fly  1107 DC---------IDDLSKHGH-HSQHQQQQGSPQQQNMQQSVQQQSVQQQQSLQQQQQQQHHQHHS 1161
            .|         ...|.:|.| |||......||........::..........:..:|::
Mouse   193 ACDVCGKTFGHAVSLEQHTHVHSQGVPAGSSPTPTLAVPGLEAPPAPDPPGPRFLRQER------ 251

  Fly  1162 NSSASSNASSHGSAEALCMGSSGGANEDSSSGNNKFVCRVCMKTFSLQRLLNRHMKCHSDIKRYL 1226
                                              .|.||:|.|.|.....|:.|:..|||.:.|.
Mouse   252 ----------------------------------SFECRMCGKAFKRSSTLSTHLLIHSDTRPYP 282

  Fly  1227 CTFCGKGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCQKVHSVQHQYAYKERRAKM 1291
            |.||||.|:...|:|:||..|||.:|:||.:|.|:|:|..:|.:|.:| |:          ..|.
Mouse   283 CQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRK-HT----------GFKP 336

  Fly  1292 YVCEEC 1297
            :.||.|
Mouse   337 FSCELC 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ovo	NP_001162673.1	C2H2 Zn finger	1199..1219	CDD:275368	7/19 (37%)
		zf-H2C2_2	1212..1235	CDD:290200	11/22 (50%)
		C2H2 Zn finger	1227..1247	CDD:275368	10/19 (53%)
		zf-H2C2_2	1239..1264	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1255..1276	CDD:275368	8/20 (40%)
Gfi1b	NP_001153878.1	C2H2 Zn finger	165..186	CDD:275368	3/20 (15%)
		C2H2 Zn finger	194..214	CDD:275368	4/19 (21%)
		zf-C2H2	253..275	CDD:278523	8/21 (38%)
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
		COG5048	263..>340	CDD:227381	31/87 (36%)
		C2H2 Zn finger	283..303	CDD:275368	10/19 (53%)
		zf-H2C2_2	295..320	CDD:290200	13/24 (54%)
		C2H2 Zn finger	311..331	CDD:275368	8/20 (40%)
		C2H2 Zn finger	339..356	CDD:275368	3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910