DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ovo and znf526

DIOPT Version :9

Sequence 1:	NP_001162673.1	Gene:	ovo / 31429	FlyBaseID:	FBgn0003028	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	NP_001120164.1	Gene:	znf526 / 100145203	XenbaseID:	XB-GENE-5881673	Length:	919	Species:	Xenopus tropicalis

Alignment Length:	756	Identity:	125/756 - (16%)
Similarity:	224/756 - (29%)	Gaps:	280/756 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   761 QLSDAVDLSSFLQRSCVDD-----------------EESTSPRQDFELVSTPSLTP--------- 799
            |.|..:.....||...:|:                 |||..|        .|:..|
Frog   142 QTSSGIQALLSLQNVLLDERALNGWGMEMPAVVASAEESAEP--------LPTTCPSTLSETITV 198

  Fly   800 -DSVTPV-EQHNTNTTQLDVLHENLLTQLTHNIVRGGSNQQQQHHQQHGVQQQQQQQHSVQQQQQ 862
             |.|.|: |.|....::..::.......|.|                       |.:|.:..:::
Frog   199 QDEVIPLPEMHPYECSECSLVFHTPEEFLEH-----------------------QGRHFMVSEKE 240

  Fly   863 HNVQQQHGVQQQHVQQQPPPSYQHATRGLMMQQQPQHGGYQQQAAIMS--------------QQQ 913
            .......||    |:...|.|        .:.::.:...:|.:..::|              :.:
Frog   241 SATSPSRGV----VENGAPSS--------AILERLRKDWFQDEKEVVSIVDLGTTKRVYRCQECK 293

  Fly   914 QQLLSQQQQQSHHQQQQQQQHAAAYQQHNIYAQQQQQQQQQHH---------------QQQQQQQ 963
            ::.::.::.:.|.::.|.::...........:..:.|..::.|               ::...:|
Frog   294 KEYVTLEELRKHRKEHQSEEFPCPDCDRLFSSANRLQSHRRVHVEGTLQCPNCYKVFKKEASLEQ 358

  Fly   964 HHHFH-----------------------HQQQQQPQPQSHHSH------------HHGHGHDNSN 993
            |...|                       |::.....| .|..|            :|...|...:
Frog   359 HMRVHRGEALYLCVDCGLGFGTEITLVLHRKSHTADP-LHRCHCGKTFSNMTKFLYHRRTHAGKS 422

  Fly   994 MSLPSP-------TAAAAAAAAAAAAAAAAAAHLQRPMSSSSSSGGTNSSNSSGGSSNSPLLDAN 1051
             .:|:|       |....:.......||:.:...|    ::..|........:|...|.|.|:|.
Frog   423 -GVPTPKTEKPIVTEMPVSPVLTEQTAASPSVTFQ----TADLSPVLTKCQVNGVVKNIPPLEAQ 482

  Fly  1052 AAAAAAAALLDTKPLIQSLGLP---------------------PDLQLEFVNGGHGIKNPLAVEN 1095
            :         :.:..:||...|                     .:|:.:....|...|..:.::|
Frog   483 S---------EVRLTVQSFKCPVCSKEFSTRLRMVRHKRVVHAVELKHKCTVCGKHFKQKVHLQN 538

  Fly  1096 ---AHGGHHRIRNIDC------IDDLSKHGHHSQHQQ---------QQGSPQQQNMQQ------- 1135
               .|.|....:..||      |..|  ..||..|..         .:|..|:.|::|
Frog   539 HMRTHTGERPFQCTDCGKAYRSISSL--RCHHLTHTGVKPYACDLCGKGFTQKSNLKQHRTLHTG 601

  Fly  1136 ---------------------------------------SVQQQSVQQQQSLQQQQQQQHHQH-- 1159
                                                   |..::.:.:...|..|.::..|.|
Frog   602 ASLFPCEVCGMKFNRASKLTLHLRAHTGALTYKCTECGKSFMRKELLELHRLGHQGKEPLHCHEC 666

  Fly  1160 -----HSNSSASSNASSHGSAEALCMGSSGGANEDSS--------SGNNKFVCRVCMKTFSLQRL 1211
                 ..:..|.....|:...:.:|.......|..:|        |....|.|:||.|.|..||.
Frog   667 AMVFEEESQLAEHKCHSNNEGQYVCPNCGKKLNSKTSLILHLLVHSDQRPFRCQVCGKCFPSQRR 731

  Fly  1212 LNRHMKCHSDIKRYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESH----- 1271
            :.||.:.||..:.:.|..|||.|..:|:|:.|.|.|||.||:.|..|.|:|.|...|..|
Frog   732 VQRHQRWHSAKRAHQCEICGKSFLASFNLRLHQRIHTGERPFPCPDCGKAFRQTTHLREHYRLHT 796

  Fly  1272 ---------C-----QKVHSVQHQYAYKERRAKMYVCEECG 1298
                     |     |.:|..:|::.:..:|.  :.|.|||
Frog   797 GERPYHCQDCGKTFVQSMHLTEHRHLHTGQRP--HSCTECG 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ovo	NP_001162673.1	C2H2 Zn finger	1199..1219	CDD:275368	9/19 (47%)
		zf-H2C2_2	1212..1235	CDD:290200	8/22 (36%)
		C2H2 Zn finger	1227..1247	CDD:275368	9/19 (47%)
		zf-H2C2_2	1239..1264	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1255..1276	CDD:275368	9/39 (23%)
znf526	NP_001120164.1	C2H2 Zn finger	17..37	CDD:275368
		C2H2 Zn finger	68..88	CDD:275368
		C2H2 Zn finger	108..128	CDD:275368
		C2H2 Zn finger	289..309	CDD:275368	1/19 (5%)
		C2H2 Zn finger	316..336	CDD:275368	1/19 (5%)
		C2H2 Zn finger	343..363	CDD:275368	2/19 (11%)
		C2H2 Zn finger	371..391	CDD:275368	1/19 (5%)
		C2H2 Zn finger	399..418	CDD:275368	2/18 (11%)
		C2H2 Zn finger	494..515	CDD:275368	1/20 (5%)
		COG5048	521..853	CDD:227381	69/319 (22%)
		zf-C2H2	521..543	CDD:278523	3/21 (14%)
		C2H2 Zn finger	523..543	CDD:275368	3/19 (16%)
		zf-H2C2_2	535..560	CDD:290200	5/24 (21%)
		C2H2 Zn finger	551..571	CDD:275368	6/21 (29%)
		C2H2 Zn finger	579..599	CDD:275368	4/19 (21%)
		C2H2 Zn finger	607..627	CDD:275368	0/19 (0%)
		C2H2 Zn finger	635..652	CDD:275368	1/16 (6%)
		C2H2 Zn finger	663..682	CDD:275368	2/18 (11%)
		C2H2 Zn finger	691..711	CDD:275368	3/19 (16%)
		C2H2 Zn finger	719..739	CDD:275368	9/19 (47%)
		C2H2 Zn finger	747..767	CDD:275368	9/19 (47%)
		zf-H2C2_2	759..784	CDD:290200	12/24 (50%)
		C2H2 Zn finger	775..795	CDD:275368	7/19 (37%)
		zf-H2C2_2	787..812	CDD:290200	3/24 (13%)
		C2H2 Zn finger	803..823	CDD:275368	4/19 (21%)
		C2H2 Zn finger	831..851	CDD:275368	4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910