Protein Alignment Ptp4E and Ptprv

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_149090.1
• Gene: Ptprv / 64576
• RGDID: 621123
• Length: 1711
• Species: Rattus norvegicus
• Alignment Length: 1867
• Identity: 428/1867 - (22%)
• Similarity: 686/1867 - (36%)
• Gaps: 519/1867 - (27%)

  Fly    60 ILTIFLAQHANAADLVINVPNASSNANAFYRIDYSPPF------GFPEPNTTIPASDIGKDIKFS 118
            :|::.::.|..:..|.::...|....     .||:...      |.|| ...:.|.......:|.
  Rat    38 LLSVNVSSHGKSTSLFLSWVAAELGG-----FDYALSLRSVNSSGSPE-GQQLQAHTNESGFEFH 96

  Fly   119 RALPGTEYNFWLYYTNSTHREQLT-----W---TVNITTAPDPPANLSVQLRSSKSAF---ITWR 172
            ..:||:.|..           :||     |   |:.:|....|.....:||.|:.|..   .:|
  Rat    97 GLVPGSRYQL-----------KLTVLRPCWQNVTITLTARTAPTVVRGLQLHSAGSPARLEASW- 149

  Fly   173 PPGSGRYSGFRIRVLGLTDLPFERS------YSLEGN----------ETLQLSAKELTPGGSYQV 221
                             :|.|.::.      |.||..          :||..|..:|.||..|.:
  Rat   150 -----------------SDAPGDQDSYQLLLYHLESQTLACNVSVSPDTLSYSFGDLLPGTQYVL 197

  Fly   222 Q----AYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITP 282
            :    |.|::      |.||....|:|..|....:.....::|...|.....|   |.:.:.:|.
  Rat   198 EVITWAGSLH------AKTSILQWTEPVPPDHLALRALGTSSLQAFWNSSEGA---TSFHLMLTD 253

  Fly   283 DDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYLTVP----ERV 343
            .....:...|.|:    |.:...|..|.||..:.:.:...:.......|:...: |.|    :.|
  Rat   254 LLGGTNTTAVIRQ----GVSTHTFLHLSPGTPHELKICASAGPHQIWGPSATEW-TYPSYPSDLV 313

  Fly   344 LNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNV--PRAANGDSVYFDYPDILEP 406
            |....:|.:.:       |:  ......|.|.:.||......:.  |...|.     .:|..|.|
  Rat   314 LTPLRNELWAS-------WK--AGLGARDGYVLKLSGPMESTSTLGPEECNA-----VFPGPLPP 364

  Fly   407 GRTYEVVVKTIADNVNSWPAS----GEVTLRPRPVRSLGGFLDDRSNALHISWEPAETGRQDSYR 467
            |. |.:.:|.:|...::|...    .|....||.|.....:||    .|..|.:|   ||:   .
  Rat   365 GH-YTLQLKVLAGPYDAWVEGSTWLAESAALPREVPGARLWLD----GLEASKQP---GRR---A 418

  Fly   468 ISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITR--- 529
            :.|.:....|        .....:.:..|......|:.|..|.:       .:||:..||::
  Rat   419 LLYSDDAPGS--------LGNISVPSGATHVIFCGLVPGAHYRV-------DIASSTGDISQSIS 468

  Fly   530 -YTRPAAPLIQEL--RSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREER----TMATNETSLTI 587
             ||.|..|...|:  ||....|.::| .....:.:.|:|.:.::|::...    .:..:..|||:
  Rat   469 GYTSPLPPQSLEVISRSSPSDLTIAW-GPAPGQLEGYKVTWHQDGSQRSPGDLVDLGPDTLSLTL 532

  Fly   588 HYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYV 652
            ..|.|||.|.|...|.:..:.|:.........|.||.||:|...|
  Rat   533 KSLVPGSCYTVSAWAWAGNLDSDSQKIHSCTRPAPPTNLSLGFAH-------------------- 577

  Fly   653 VRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSNVVP 717
                                                                     ||.:
  Rat   578 ---------------------------------------------------------QPAA---- 581

  Fly   718 LVDSRNLTLEWPRPDG-----HVDFYTLKWWP-TDEEDRV---EFKNVTQLEDLSSPSVRIPIED 773
                  |...|..|.|     |:..|.|:  | |.|.::|   |.:|.:..:
  Rat   582 ------LKASWYHPPGGRDAFHLRLYRLR--PLTLESEKVLPREAQNFSWAQ------------- 625

  Fly   774 LSPGRQYRFEV------QASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPT 832
            |:.|.:::.::      :.||:...:|.|..|..|:..:.||.           ...:.:|:...
  Rat   626 LTAGCEFQVQLSTLWGSERSSSANATGWTPPSAPTLVNVTSDA-----------PTQLQVSWAHV 679

  Fly   833 PADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYR 897
            |...:|   |:.::...:.:....:....|...||.|||||..|.|.|.:.:|.:.:........
  Rat   680 PGGRSR---YQVTLYQESTRTATSIMGPKEDGTSFLGLTPGTKYKVEVISWAGPLYTAAANVSAW 741

  Fly   898 LHPL-PISDLKAIQVAAREITLHW-TAPAGE-----------YTDFELQYLSADEEAPQLLQNVT 949
            .:|| |...|.::|..:..:.|.| :.|.|:           :..:| |.|...:|.
  Rat   742 TYPLIPNELLVSMQAGSAVVNLAWPSGPLGQGACHAQLSDAGHLSWE-QPLKLGQEL-------- 797

  Fly   950 KNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQ 1014
                ..|:.|.|.|..:.:|..|:|.:|.                  |.....|:..||.|:
  Rat   798 ----FMLRDLTPGHTISMSVRCRAGPLQA------------------STHLVVLSVEPGPVE--- 837

  Fly  1015 PSDV--QPGEVTF---EWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVP- 1073
              ||  .| |.|:   .|:: ||   |.:|...:.                       ::.|||
  Rat   838 --DVLCHP-EATYLALNWTM-PA---GDVDVCLVV-----------------------VERLVPG 872

  Fly  1074 -GNHYIFRIQAK-------------------SALG--------------YGAEREHIQTMPILAP 1104
             |.|::|::...                   :.||              ..||..|       .|
  Rat   873 GGTHFVFQVNTSGDALLLPNLMPTTSYRLSLTVLGRNSRWSRAVSLVCSTSAEAWH-------PP 930

  Fly  1105 PVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYT 1169
            .:.||....|     .:.:.::..:|.|....|.::.|.||...::     .|..||.:.:. ||
  Rat   931 ELAEPPQVEL-----GTGMGVTVMRGMFGKDDGQIQWYGIIATINM-----TLAQPSREAIN-YT 984

  Fly  1170 VWLP--YQAIEPY------NPFLTS--NGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTY 1224
             |..  |:..|.:      |||...  .|.|..::     .:||.:||..|. .|||.|::|..|
  Rat   985 -WYDHYYRGCESFLALLFPNPFYPEPWAGPRSWTV-----PVGTEDCDNTQE-ICNGRLKSGFQY 1042

  Fly  1225 RIKIRAF----TDEDKFTDTVYSSPITTERSD--------TVIVAATVSAVLLVAMVLVVVYCQH 1277
            |..:.||    |.|.....:.:|.|    |:.        ||::.|.|.::::|..||.::  :.
  Rat  1043 RFSVVAFSRLNTPETILAFSAFSEP----RASISLAIIPLTVMLGAVVGSIVIVCAVLCLL--RW 1101

  Fly  1278 RCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRD 1342
            ||....|:.| .....||  :|......:||:.:..|.:.|...||.:...|.:||||||.||:|
  Rat  1102 RCLKGPRSEK-DGFSKEL--MPYNLWRTHRPIPIHSFRQSYEAKSAHAHQTFFQEFEELKEVGKD 1163

  Fly  1343 QACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHS 1407
            |....|..|.|..|||:.::|||||||.:|..:..:..|||||||::||::..:|.|.|||||..
  Rat  1164 QPRLEAEHPDNIIKNRYPHVLPYDHSRVRLTQLPGEPHSDYINANFIPGYSHTQEIIATQGPLKK 1228

  Fly  1408 TREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEF 1472
            |.|:|||:.||.....|:|||...|.||..|:.|||.:...:.:|.|.:.|:.:....:|:..||
  Rat  1229 TLEDFWRLVWEQQVHVIIMLTVGMENGRVLCEHYWPANSTPVTHGHITIHLLAEEPEDEWTRREF 1293

  Fly  1473 MVSRNCE--SRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDM--RPIIVHCSAGVGRSG 1533
            .:....|  .|.::...||||||..|||.|.||:.||...::.:....  .||:|||||||||:|
  Rat  1294 QLQHGTEQKQRRVKQLQFTTWPDHSVPEAPSSLLAFVELVQEQVQATQGKGPILVHCSAGVGRTG 1358

  Fly  1534 TFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLL-AVLEGKEHLLADSLE 1597
            ||:||.|:|:.:.:....|:|..|:.:|..|..|:||..||:.:|.||| .:|||.    .||.:
  Rat  1359 TFVALLRLLRQLEEEKVADVFNTVYILRLHRPLMIQTLSQYIFLHSCLLNKILEGP----PDSSD 1419

  Fly  1598 -----------------LHANDGYEVTKIYLERQPQTKMGTLPIRASLAMAEKLDADLMTNKDED 1645
                             .:||.|:  .|.|...:...|.||    .||......:.:.:.::...
  Rat  1420 SGPISVMDFAQACAKRAANANAGF--LKEYKLLKQAIKDGT----GSLLPPPDYNQNSIVSRRHS 1478

  Fly  1646 EDQ---EQQQQQQLQLATEVKPKGSNDDEEDEEDDDDDDDDQQPLNNETTATLSSASCSSS---- 1703
            ::|   .::..:...|...:.|.|                   |...:......||.....
  Rat  1479 QEQFALVEECPEDSMLEASLFPGG-------------------PSGCDHVVLTGSAGPKELWEMV 1524

  Fly  1704 -THDVHVV----LQEAIEKPKQ----EQERICAGTQS-HADTESDNT 1740
             .||.||:    |.:..|||..    |.:.|.....: |..:||:.|
  Rat  1525 WEHDAHVLVSLGLPDTKEKPPDIWPVEMQPIVTDMVTVHRVSESNTT 1571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	52/276 (19%)
		fn3	247..328	CDD:394996	13/80 (16%)
		FN3	319..>749	CDD:442628	84/455 (18%)
		fn3	708..796	CDD:394996	20/102 (20%)
		fn3	902..978	CDD:394996	18/87 (21%)
		fn3	1013..1092	CDD:394996	18/118 (15%)
		PTP_tm	1127..1247	CDD:465889	37/133 (28%)
		R3-PTPc	1358..1579	CDD:350396	93/224 (42%)
Ptprv	NP_149090.1	FN3	49..110	CDD:214495	13/77 (17%)
		fn3	<148..201	CDD:394996	13/70 (19%)
		FN3	377..>749	CDD:442628	96/513 (19%)
		PTP_tm	950..1069	CDD:465889	37/135 (27%)
		PTP_DSP_cys	1178..1407	CDD:475123	96/228 (42%)
		PTP_DSP_cys	1477..1693	CDD:475123	21/114 (18%)