Protein Alignment Ptp4E and ptpn20

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_002664234.3
• Gene: ptpn20 / 571774
• ZFINID: ZDB-GENE-090313-90
• Length: 2195
• Species: Danio rerio
• Alignment Length: 1667
• Identity: 354/1667 - (21%)
• Similarity: 577/1667 - (34%)
• Gaps: 482/1667 - (28%)

  Fly   193 PFERSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKESVAYTSRNFTT------------KPN 245
            |.::|.|....||.......:....|.|.|...|:....|:...:...||            .|.
Zfish   722 PKDQSQSSSPLETFSPPVYRIMSNVSLQKQDSEVHSTTSSIRVDTPTKTTPEREIICVTLKKDPK 786

  Fly   246 TPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLV 310
            ....||:...:.|..|.|       ||:.   .||.||                |||....: :.
Zfish   787 LGYGFIIVGEDNTGKLDL-------GIFI---ASIIPD----------------GPADKDGR-IR 824

  Fly   311 PGREY----NISVQTVSEDETSSVPTTARYLTVPERV----------------------LNVTFD 349
            ||...    |||::.|:.:..:|:...:     ||.|                      |.:..:
Zfish   825 PGGRLISLNNISLEGVTFNIAASILQNS-----PEEVELIVSQPKQDLRGSKTSLAPSNLGMMLE 884

  Fly   350 EAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNVP------------RAANGDSVYFDYPD 402
            .::.:.|:....:.|.....|.....:|.....:..::|            ::::|.|
Zfish   885 RSFGSQSTLSAEYRPVMEELEETLSNIMAPKINKRMHIPVVRILDIQDEMSKSSSGFS------- 942

  Fly   403 ILEPGRTYEVVVK--------TIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNALHISWEPAE 459
             |:||....:.::        ::|..:|:....|.:.::    ..:.|...|:...:.|.....|
Zfish   943 -LKPGEIIYMELRKINGSLGISVAGGINTNVHHGGIYIK----SVIAGGAADQDGRIQIGDRLLE 1002

  Fly   460 TGRQD--SYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVAS 522
            .   |  :.|...|.|            |.|....|.    .:.||:..|...:.:.      .|
Zfish  1003 V---DGCNLRAVTHRQ------------AVECLKRTG----EVVSLVLEREPPVVLD------TS 1042

  Fly   523 NASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRY-------EVHYQRNGTREERTMAT 580
            :||......|..:||...||   :.:.|.....|.::..|:       ||..|       ::.:.
Zfish  1043 SASSTLERRRSPSPLSAPLR---RDVPLQTPLSVRTKDFRFVSDENILEVTLQ-------KSFSG 1097

  Fly   581 NETSLTIHYLHPGSGYEVKVHAISHG-----------------VRSEP---HSYFQA--VFPKPP 623
            ...|..:..|.|.....|::.::|.|                 |..||   .||.:.  :..|.|
Zfish  1098 LGFSFLVSELGPEKENIVQIKSLSSGHPAGDCGLLKEGDIILAVNGEPVRGLSYEEVLHLLQKSP 1162

  Fly   624 QNLTL------QTVHTNLVV------------LHWQAPE-GSDFSEYVVR------YRTDASPWQ 663
            ..:.|      |..||::..            |..||.. ..||||.::|      .:.:|||.:
Zfish  1163 SEIRLSICRPSQDEHTDIETFLVPNRELRSRSLDLQARSVAPDFSELLLRRAIEMGLKKEASPEE 1227

  Fly   664 -RISGLHENEARI--------KDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSNVVPLV 719
             :.|.|.|.:..|        .....|||....:....:..:.|.|       ||.|......|.
Zfish  1228 TQESELLETDKSIPPPLPPRPSSAEGGERKPHVILVEEYEKKDPPP-------PPTPPPTPGILK 1285

  Fly   720 DSRNLTLEWP-RPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIE----------- 772
            .|...|::.| .|...:..:        :::.:| ..|::...:|:.:..:..|
Zfish  1286 ASTTNTVQTPAAPKTAIKAH--------QQESLE-PTVSRSNHVSACTSHVKDEGVEENVISFTA 1341

  Fly   773 ---DLSPGRQYRFEVQASSNGIRSGTTHLST--------------RTMPLIQSDVFIA------- 813
               .::.|.:| ..:..::....||:|.:|:              .|.|..|..:..|
Zfish  1342 NGLTVTAGEEY-LTISTTAPSPPSGSTAVSSEAPPPVPALSPSLLNTPPTYQQAIQAASPAEPPA 1405

  Fly   814 ---NAGHEQGQDE-------------TITLSYTPTPADSTRFDIYRFS----------MGDPTIK 852
               |.|.:...:|             .:|:|.|.:...|..|.|.|..          :.:|...
Zfish  1406 QPSNNGWDDDDEEDDEDPRRDVFKEFELTVSLTKSWCGSFGFTITRSKLDNCYYVQDVLDNPAKA 1470

  Fly   853 DKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASL-------------PVQRLYRLHPLPIS 904
            |....|.|  |.:..:|      :|||..|....::.|             .||.|  |.|.|..
Zfish  1471 DGRLRAGD--RLIMVNG------HNVTSVTDDVAISILRCSSKRLHMVLGRAVQNL--LPPPPPD 1525

  Fly   905 DLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTV 969
            .|:.|.::        ..|:|                 ||...:|.......||:     |...|
Zfish  1526 TLQDIIIS--------KTPSG-----------------QLGIKLTGGIGSKRQGI-----YVQEV 1560

  Fly   970 VVRS-----GSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQP------GEV 1023
            |:.|     ||||..| ..|.:.........:..:.:...:.|.||.:....|.||      ...
Zfish  1561 VLSSPASEEGSIQPND-KIVYICGRCTLGMTLEDAVKVCESSPRKVRFKAMRDDQPVIPRDKWNG 1624

  Fly  1024 TFEWSLEPAEQH--GPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSA 1086
            .|||..:....|  .|:            :.||.|....|.|        |..:..:||    ..
Zfish  1625 LFEWKEKKGFPHLEEPM------------SPDVHSALADVKA--------VADSAMLFR----KR 1665

  Fly  1087 LGYGAEREHIQTMPILAPPVPEPSVTPLEVSR----TSSTIEI-SFRQGYFSNAHGMVRSYTIII 1146
            |...||:|..    ||.....:|....|..:.    ..||:.: ....|..:...|.:|...|::
Zfish  1666 LSVTAEQESC----ILQVEFTKPDRGGLGFALVGGVNGSTLRVKDICCGGVAEQDGRLRVGDILL 1726

  Fly  1147 --------------AEDVGKNASG-LEMPSWQDVQAYTVWLPYQA-------IEPYNPFLTSNGS 1189
                          ..|:.:.|.| :::...:|:      ||..|       .|.:..|.|.|.:
Zfish  1727 EVNGIIVSGLSHSKVVDILRKAEGTVQLTVCRDI------LPMSACSASNYPTEAHGNFNTLNSA 1785

  Fly  1190 RKSSLEAEH--FTIGTANCDKHQAGYCNGPLR-----AGTTYRIKIRAFTDEDKFTDTVYSSPIT 1247
            .::....:|  |......|:: ::..|....:     .|.|..::.:  ||..|  ..:.:|.:.
Zfish  1786 AQTEAHPDHVSFHSDCPECEQ-ESRNCTPTCQRCCPSLGVTDMLQEK--TDPQK--QHLENSAMK 1845

  Fly  1248 TERS----------------DTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELA 1296
            ||.|                |.....:....:.|....:|                   .::||:
Zfish  1846 TEHSQSDGWSSDEEEDGDDDDCASQPSPPETIPLTGRPIV-------------------SEEELS 1891

  Fly  1297 AL------PEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRP 1355
            :|      ..|..|.:|   ||...:....:....   ..:||..|:|:.....|.....|.||.
Zfish  1892 SLAVISPPKNGQYTGSR---VKALIQALEQLEKQD---LVKEFMALEHLNPSDNCLVGKAPENRE 1950

  Fly  1356 KNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPRE--FIVTQGPLHSTREEFWRMCWE 1418
            |||:..|||||.:|.   ||.:|:|  ||||:|:.......|  ||..||||..|::.||:|.||
Zfish  1951 KNRYREILPYDKTRV---PVGEDEG--YINASYIRMKVGSEELFFISAQGPLPGTQDSFWQMVWE 2010

  Fly  1419 SNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTH----YHDWSISEFMVSRNCE 1479
            :.|..|.|:||..|:||.||.:||| :::.:.....:.||.:|.:    |....:.:.:..::.:
Zfish  2011 NRSDVIAMMTREVERGRVKCHKYWP-EKLDVPKETSRYQLFLDNYQMLGYFHIKVIKMVEKKSGD 2074

  Fly  1480 SRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQH 1544
            ...::|..||||||.|.|.....||||:|..|.|....  ||.||||||:||:|..|..|.||..
Zfish  2075 VHFVKHLKFTTWPDHGTPHSSDQLVRFIRYMRAVHAKG--PITVHCSAGIGRAGVLICTDVILSL 2137

  Fly  1545 IHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE 1586
            |.|...:::..||..||.:|..|:||::||:..::..|.||:
Zfish  2138 IQKDLSINVSDIVKEMRLQRHGMIQTKEQYLFCYKVWLEVLQ 2179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	34/156 (22%)
		fn3	247..328	CDD:394996	20/84 (24%)
		FN3	319..>749	CDD:442628	92/537 (17%)
		fn3	708..796	CDD:394996	16/102 (16%)
		fn3	902..978	CDD:394996	17/80 (21%)
		fn3	1013..1092	CDD:394996	17/86 (20%)
		PTP_tm	1127..1247	CDD:465889	25/148 (17%)
		R3-PTPc	1358..1579	CDD:350396	89/226 (39%)
ptpn20	XP_002664234.3	Protein Kinases, catalytic domain	6..154	CDD:473864
		FERM_F1_FRMPD2	342..431	CDD:340716
		B41	344..546	CDD:214604
		FERM_C_PTPH13	542..643	CDD:270008
		PDZ1_FRMPD2-like	775..865	CDD:467284	25/121 (21%)
		PDZ2-PTPN13_FRMPD2-like	947..1033	CDD:467254	16/108 (15%)
		PDZ3_PTPN13_FRMPD2-like	1086..1172	CDD:467181	17/92 (18%)
		KLF10_11_N	<1286..>1401	CDD:425362	18/124 (15%)
		PDZ4_PTPN13-like	1430..1514	CDD:467182	18/91 (20%)
		PDZ_canonical	1525..1612	CDD:483948	22/117 (19%)
		PDZ5_DrPTPN13-like	1678..1757	CDD:467273	11/78 (14%)
		PTPc-N20	1973..2179	CDD:350444	80/208 (38%)