Protein Alignment Ptp4E and ca16b

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_021332937.1
• Gene: ca16b / 569183
• ZFINID: ZDB-GENE-080818-1
• Length: 1382
• Species: Danio rerio
• Alignment Length: 1396
• Identity: 325/1396 - (23%)
• Similarity: 506/1396 - (36%)
• Gaps: 415/1396 - (29%)

  Fly   389 RAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPV-------------RSL 440
            |.|:|:. |:.|.....|.|.           .:::|..||....|..:             .:|
Zfish    47 RRASGEP-YWAYSGTYGPRRW-----------ASAYPECGERNQSPVDILDPETQVSQECQELTL 99

  Fly   441 GGFLDDRSNALHISWEPAET-----------------GRQDSYRISYH-EQTNASEVP------A 481
            .||....||...:. ...:|                 ||..:.::.:| ..||.|...      .
Zfish   100 DGFETKSSNRTTMK-NTGKTVSIVLKNDYFVRGAGLPGRFKAEKVEFHWGSTNGSAGSEHSINGK 163

  Fly   482 PFPVAAESQI-TTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLIQELRSID 545
            .|||  |.|| ..|..::...|.....|.:||..|:...||      |:....|.|:|..|:.:
Zfish   164 KFPV--EMQIYFYNSDDFDSLSTAIKERRIIAAMAVFFQVA------TKDNIAAEPIIAGLKRV- 219

  Fly   546 QGLMLSWRSDVNSRQDRYEVHYQRNGTREERTMATNETSLTIHYLHP---GSGYEVKVHAISHGV 607
                               ||:::.         ||..|..:..|.|   ||.|.
Zfish   220 -------------------VHHEKE---------TNLGSFILRDLLPSSLGSYYR---------- 246

  Fly   608 RSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQ---------APEGSDFSEYVVRYRTDASPWQ 663
                  |..::...|...:....:.:..|.|.:.         ..|..|..:.|...|.:..|.|
Zfish   247 ------YTGSLTTPPCSKVVEWIIFSRPVYLSYHQLEAFYSIFTTEQQDHVKSVDYLRNNHRPIQ 305

  Fly   664 RISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEW 728
            .:......::.:.|....|......:|.:..|.|..|..:.:    .|::...       |.|.|
Zfish   306 DLDSRRIFKSALMDAWMPETMASAADTETSRVCSSIPDNMKL----HPLNRTA-------LVLTW 359

  Fly   729 PRPDG--H---VDFYTLKWWPTDEEDRVEF-KNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQAS 787
            .||..  |   |.|.....|..||   :.| |..||   .|..|.|..|..:||...|.|.|||
Zfish   360 DRPSAVYHPPIVGFLVSYSWVKDE---MPFEKTFTQ---SSEHSTRAVITLVSPDVLYLFRVQA- 417

  Fly   788 SNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTR-FDIYRF-SMGDPT 850
                             |.|.|         |..|.:.||.:   .|::|| |:..|. ..|.||
Zfish   418 -----------------LCQRD---------QRSDFSQTLLF---KANTTRIFEGTRIVKTGMPT 453

  Fly   851 IKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAARE 915
            :..    |:..:.....||        .:.||.:|               ||.|   .:.:|.
Zfish   454 VSP----ASSADMAPISSG--------SSTWTSAG---------------LPFS---FVSMAT-- 486

  Fly   916 ITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEITLQGLRPYHN---YTFTVVVRSGSIQ 977
                                                      |:.|..:   .|...||.|..:.
Zfish   487 ------------------------------------------GMGPPSSGGQATVASVVTSTLLA 509

  Fly   978 GTDFADVSVSTLMRSSAPISASYQTLTAP-PGKVDYFQPSDVQPGEVTFEW--SLEPAEQHGPID 1039
            |..|:...:|:|..|..|   ::.|.|.| |.:......::..|.|.:.:.  .||..|:|
Zfish   510 GLGFSGSVISSLPGSFWP---THSTNTGPSPTQHPATPTAENSPSEDSTDTQNKLEEEEEH---- 567

  Fly  1040 YFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAP 1104
                  :..||..:....|......:.|            :.:.|..    ..::..||:.....
Zfish   568 ------KKEDDEEEEEEEEEEEQRDEEK------------KKKGKDV----TVKDKKQTVQKPTA 610

  Fly  1105 PVP-------------EPSVTPLEV-SRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNAS 1155
            |:|             ..::||.|| .:.|...|   |..                |||..|
Zfish   611 PIPTSKHRDRERPDAESSTLTPAEVEEQVSGATE---RPD----------------AEDSSK--- 653

  Fly  1156 GLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRA 1220
                .:|||.....:              .|:.:..|.|..|.                    :|
Zfish   654 ----ATWQDDNDMQI--------------PSSSTESSKLSDEE--------------------KA 680

  Fly  1221 GTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVAMVL---VVVYCQHRCQ-- 1280
            ...|.|.    |:.:..:.....|..::.|.:.:|....|||:.|:.:::   |:||.:...|
Zfish   681 NWPYYIN----TERNSISTVSRDSVSSSSRMEWIIPLMVVSALTLLCLIMLLAVLVYWRRFFQTA 741

  Fly  1281 -----------LIRRAS-KLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSEEF 1333
                       :|...| .:....|:|.|:|           |:.|.:|...:.:::...||:||
Zfish   742 HFYIEDRNSPRVIHNDSFPIISTADDLEAMP-----------VRQFIKHIMELHSNNRHGFSQEF 795

  Fly  1334 EELKHVGRDQ--ACSFANLPCNRPKNRFTNILPYDHSRFKLQ--PVDDDDGSDYINANYMPGHNS 1394
            :|::|...:.  ....:|.|.|:.|||:.||:.|||||.|||  |..|...||||||||:.|:..
Zfish   796 DEVQHCTSEMKITAEHSNHPENKHKNRYINIVAYDHSRVKLQQLPGKDSKHSDYINANYVDGYKR 860

  Fly  1395 PREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLI 1459
            .|.:|..||||.||.|:||||.||.|:..|||:|...||||.|||||||.:. :..||:|.|.|.
Zfish   861 ARAYIAAQGPLKSTFEDFWRMIWEQNTTVIVMITNLVEKGRRKCDQYWPSEN-SEVYGNIMVTLK 924

  Fly  1460 IDTHYHDWSISEFMVSRNCE----------SRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVI 1514
            ....|..:::..|:| ||.:          .|::..:|:|.|||.||||....:::|:.......
Zfish   925 STKVYAYYTLRHFIV-RNSKLKKGQKGRQNERLVLQYHYTQWPDMGVPEYTLPVLKFISRSTVTH 988

  Fly  1515 GTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQ 1579
            .:...|::|||||||||:||:|.:|.:|:.|.....|::.|.:..:|::|.::||||:|::.||.
Zfish   989 ASSTGPVLVHCSAGVGRTGTYIVIDSMLKQIKDRGSVNVLGFLKHIREQRNYLVQTEEQFIFIHD 1053

  Fly  1580 CLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQP--QTKMG---TLPIRASLAMAEKLDADLM 1639
            .|:      |.:|:...|:.|...:..|...|...|  .|:|.   .|..:.:..:||.|.....
Zfish  1054 ALM------EAVLSKDTEVSAWQLHTYTNSLLTPSPTGHTRMDKHFKLLTQCNAHLAECLSGQKE 1112

  Fly  1640 TNKDEDEDQEQQQQQQLQLATEVKP--KGSN 1668
            .||:::........::.::|....|  ||::
Zfish  1113 CNKEKNRTSAVLPTERARVALSPLPGLKGTD 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	80/414 (19%)
		fn3	708..796	CDD:394996	27/93 (29%)
		fn3	902..978	CDD:394996	9/78 (12%)
		fn3	1013..1092	CDD:394996	11/80 (14%)
		PTP_tm	1127..1247	CDD:465889	17/119 (14%)
		R3-PTPc	1358..1579	CDD:350396	100/232 (43%)
ca16b	XP_021332937.1	alpha_CARP_receptor_like	62..314	CDD:239396	57/316 (18%)
		FN3	340..417	CDD:214495	26/93 (28%)
		PTP_DSP_cys	791..1060	CDD:475123	114/276 (41%)
		R-PTP-G-2	1144..1348	CDD:350508	325/1396 (23%)