Protein Alignment Ptp4E and ptpro

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_001077283.1
• Gene: ptpro / 407676
• ZFINID: ZDB-GENE-070424-54
• Length: 1238
• Species: Danio rerio
• Alignment Length: 1360
• Identity: 347/1360 - (25%)
• Similarity: 564/1360 - (41%)
• Gaps: 340/1360 - (25%)

  Fly   437 VRSLGGF-------------LDD-------RSNALHISWEPAETGRQDSYRISYHEQTNASEVPA 481
            ::|..||             |||       ...|:.:|.||.      ::.:.:.:..:|..:|.
Zfish    16 IQSAAGFRVQLQDGVRMLMSLDDGDIGPGVSEYAVRVSGEPL------THTLLFQQAADAHTLPE 74

  Fly   482 P--FPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYT-RPAAPLIQELRS 543
            |  |..:....:      |::..:..||.:... ..:::.:..::.::..|. .|...::.::||
Zfish    75 PLLFNASYHGLL------YSISLMTDGRTHTTR-SIITQPLPLDSVEMWDYAPSPETAVVFQIRS 132

  Fly   544 IDQGLMLSWRSDVNSRQDRYEVHYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGV- 607
            .|:.:.           .|..:.|...  .:.|.|...:      :||   |..|..|.:| ||
Zfish   133 PDRNIF-----------TRVNISYTEG--HQRRYMLYKD------FLH---GKTVFKHWLS-GVC 174

  Fly   608 ---------------------RSE-PHSYFQ-AVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFS 649
                                 ||: .|:..| ...|.||.|::|:.:|     |..:.|.|...:
Zfish   175 YSNITFQLISEASVNRSALLSRSDITHNPQQHRTVPNPPLNVSLKILH-----LSGRGPPGPVLT 234

  Fly   650 EYVVRYRTDASPWQRISGL--HENEARIKDMHYGERYL--VQVNTVSFGVESPHPLELNVTMPPQ 710
            ..:::...:||..:|...|  :|.:....|....|..|  .|:|.    .||.:..|      .:
Zfish   235 GAILKNSHNASVVRRERDLPEYEEQEPTSDTLNTESNLTHTQLNQ----SESENESE------SE 289

  Fly   711 PVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKN--VTQLEDLSSP--SVRIPI 771
            ||: ..|.::|...:| |.       :.|:...||:||:. .|.|  |.:.||.:.|  ::.||:
Zfish   290 PVT-AEPTLNSSTQSL-WA-------WQTVSPAPTEEEEE-GFVNALVPEYEDSNEPGSALGIPL 344

  Fly   772 EDL----------------------SPGRQY-RFEVQASSNGIRSGTTHLSTRT----MPLIQSD 809
            |..                      :|...| .|.:....||..:.|..:...|    ..|.:|.
Zfish   345 EPAVMPAVMPTPLAPVLLQLRWSPPAPHTAYDAFNIYIYRNGNSTETATVDENTHEFLAELSESG 409

  Fly   810 VF------IANAGH-----------------------EQGQD------------ETITLSYTPT- 832
            .:      :::||.                       ||.|:            .|..:|:.|:
Zfish   410 TYRIHVTTLSSAGDCEARESSANTAFTFYLSPSGEWMEQPQERPQAVSVKMLDSSTAAVSWAPST 474

  Fly   833 -PADSTRFDIYRFSMGDPTIKDKEKLANDTERKLS---FSGLTPGKLYNVTVWTVSGGV---ASL 890
             ..:.:...:...:...|:|..:.:|...:|..::   .|.||||..|.|.|:..:|.:   ||.
Zfish   475 HTYNGSLISVQSLTCLRPSISQRMELNYCSEENITSDIISSLTPGAQYRVVVYHTNGPLVSPASE 539

  Fly   891 PVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTEIT 955
            ||  :..:.|..:.||....::...:.|.|..|   |.....:|         :||....|:...
Zfish   540 PV--IIDIEPTGVRDLVVYPLSPSAVILSWQRP---YNVAFRKY---------VLQTFFFNSATQ 590

  Fly   956 LQGLRPYHNYTFTVVVRSGSIQGTD-----FADVSVSTLMRSSAPIS----ASYQTLTAPPGKVD 1011
            ......|:....|..| ..|::.||     |.:..|:.:.....|:|    ::...:|||  :..
Zfish   591 TAQWSTYYEIAATASV-IASVRVTDLLPAWFYNFRVTMVTWGDPPLSCCDTSTVSFITAP--EAP 652

  Fly  1012 YFQPSDVQPGEVTFEWS---LEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKID---G 1070
            :....:...|.|...|:   |.....|..:.::::..:....|    ...|.|:.|:..:.   .
Zfish   653 HISSVEFSHGSVFVRWTYGDLFTDLTHSRMLHWQVVAEGKKSA----RRRFSVDVTRSVMKASLA 713

  Fly  1071 LVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNA 1135
            |..|:.|...:.|.:.........||..:    .|.|..|:..:..|.||.|:        ....
Zfish   714 LPAGDIYNLTVTACTERSCNTSAPHIMKL----DPAPPRSLYAVNASDTSVTL--------IWAE 766

  Fly  1136 HGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFT 1200
            .|:|..| :|....:|.:|...::                    ..|.:||         |...|
Zfish   767 EGVVDHY-LITCRALGAHAEQKKV--------------------REPLVTS---------AHVLT 801

  Fly  1201 IGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTER----SDTVIVAATVS 1261
            :              ..|:|.|||...:|: :.....:|.|:.:..||.|    |...|.|..|.
Zfish   802 V--------------SGLQASTTYNCSVRS-SSYSSSSDPVHITVSTTVREMNPSVAAISALAVL 851

  Fly  1262 AVLLVAMV---LVVVYCQHRCQLIRRAS-----KLARMQDE--------------LAALPE---- 1300
            :|||::::   |:|:..:| .:|.|...     ..|..:.:              |..||.
Zfish   852 SVLLISLLVLFLLVLRKKH-MELSRECGAETFVNFASFERDGKLPYNWRRSLFAFLTLLPSCLWT 915

  Fly  1301 -----GYITP-----------NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFAN 1349
                 .||.|           ..||.:.||..:.:.|..||.::||.:|||||.||.|.:...|:
Zfish   916 DYLLAFYINPWSKTALKKRKLTSPVQLSDFEAYLKDMGKDSAYKFSLQFEELKSVGLDLSHEAAD 980

  Fly  1350 LPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWR 1414
            ||.||||||:|||||||.||.||..:.:|:|||||||||:||:|||||:|.|||||..||.:||:
Zfish   981 LPINRPKNRYTNILPYDFSRVKLISLHNDEGSDYINANYIPGYNSPREYIATQGPLPDTRNDFWK 1045

  Fly  1415 MCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCE 1479
            |..:.....|||||:|.|:.|.|||.|||.....:.||:|.|:::.:|...:|:|..|.::...|
Zfish  1046 MVLQQKVHIIVMLTQCNERRRVKCDHYWPFSDEPVAYGEISVEMLAETDSPEWTIRSFRLAYADE 1110

  Fly  1480 SRIMRHFHFTTWPDFGVP--EPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRIL 1542
            ::.:.||::|:|||.|||  ...:|:::||:..|..:.....||:|||||||||:||||:|||::
Zfish  1111 TQDVLHFNYTSWPDHGVPTVNAIESILQFVQIVRQQVNRSKGPIVVHCSAGVGRTGTFISLDRLM 1175

  Fly  1543 QHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHAND 1602
            |||.:.:|||:.|:|..||..|:.|||||:|||.||||:|.:.:.|:.      :.|.:|
Zfish  1176 QHIQEHEYVDVLGLVSDMRSHRLSMVQTEEQYVFIHQCVLLMWKKKKQ------QSHTSD 1229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	70/362 (19%)
		fn3	708..796	CDD:394996	25/114 (22%)
		fn3	902..978	CDD:394996	14/75 (19%)
		fn3	1013..1092	CDD:394996	13/84 (15%)
		PTP_tm	1127..1247	CDD:465889	19/119 (16%)
		R3-PTPc	1358..1579	CDD:350396	114/222 (51%)
ptpro	NP_001077283.1	FN3	<367..>628	CDD:442628	53/275 (19%)
		FN3	547..647	CDD:238020	21/112 (19%)
		FN3	744..812	CDD:214495	22/119 (18%)
		R-PTPc-O	973..1217	CDD:350462	127/243 (52%)