Protein Alignment Ptp4E and Ptp69D

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Alignment Length: 1272
• Identity: 281/1272 - (22%)
• Similarity: 492/1272 - (38%)
• Gaps: 261/1272 - (20%)

  Fly   528 TRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQD--RY-------EVHYQRNG--TREERTMATN 581
            |||.....|    |:|.|.|      |:.|..||  :|       :|:.:.:|  |...:|...:
  Fly    66 TRYKIRTEP----LKSNDDG------SENNDSQDFIKYKNVLALLDVNIKDSGNYTCTAQTGQNH 120

  Fly   582 ETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGS 646
            .|...:....|....:.....|...::.:...|  .:....|||   :|.:.|   |.| ..:||
  Fly   121 STEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLY--CLIEMYPQN---ETTNRN---LKW-LKDGS 176

  Fly   647 DFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLEL---NVTMP 708
            .| |::       ..:..||.|::..... .:.:.|.|..:..|....|.....||:   .:|:.
  Fly   177 QF-EFL-------DTFSSISKLNDTHLNF-TLEFTEVYKKENGTYKCTVFDDTGLEITSKEITLF 232

  Fly   709 PQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPS------- 766
            ...|..|         ::::.:..|....| |.|...|..|.:: |....|::..:|:
  Fly   233 VMEVPQV---------SIDFAKAVGANKIY-LNWTVNDGNDPIQ-KFFITLQEAGTPTFTYHKDF 286

  Fly   767 -----VRIPIEDLSPGRQYRFEVQASSNGIRSG-TTHLSTRTMPLIQSDVFIANAGHEQGQDETI 825
                 ....::...|...|...: ...|.|.:| .|........|....:||...........||
  Fly   287 INGSHTSYILDHFKPNTTYFLRI-VGKNSIGNGQPTQYPQGITTLSYDPIFIPKVETTGSTASTI 350

  Fly   826 TLSYTPTPADSTRFDIY---------------------RFSMGDPTIKDKEKLANDTE-RKLSFS 868
            |:.:.|.|.|...:..|                     :.|...|.:.||.|.|.|.| |..:.|
  Fly   351 TIGWNPPPPDLIDYIQYYELIVSESGEVPKVIEEAIYQQNSRNLPYMFDKLKTATDYEFRVRACS 415

  Fly   869 GLTP--GKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPA---GEYT 928
            .||.  |........|...|||:.|.....:.|...::       ....|.::|..|.   |:..
  Fly   416 DLTKTCGPWSENVNGTTMDGVATKPTNLSIQCHHDNVT-------RGNSIAINWDVPKTPNGKVV 473

  Fly   929 DFELQYL-----SADEE--APQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSV 986
            .:.:..|     :.|.|  .|::.:....:.:...:.:.|..|||.||              .::
  Fly   474 SYLIHLLGNPMSTVDREMWGPKIRRIDEPHHKTLYESVSPNTNYTVTV--------------SAI 524

  Fly   987 STLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLE---P--AEQHGPIDYF----- 1041
            :...::..|.:.|.....:.|..:.....|.|   .:..::.|:   |  :|::|||..:
  Fly   525 TRHKKNGEPATGSCLMPVSTPDAIGRTMWSKV---NLDSKYVLKLYLPKISERNGPICCYRLYLV 586

  Fly  1042 RITCQNAD----DAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQA----KSALGYGAEREHIQT 1098
            ||...|.:    :..::::|:      :...|.:...:.||..:.:    :..:..|.|:...:.
  Fly   587 RINNDNKELPDPEKLNIATYQ------EVHSDNVTRSSAYIAEMISSKYFRPEIFLGDEKRFSEN 645

  Fly  1099 MPIL-------------APPVPEPSV--TPLEVSRTSSTIE---ISFRQGYFSNAHGMVRSYTII 1145
            ..|:             .|.:.:|.:  .|.:.|.::|..|   :|.:......|:  :..:.:.
  Fly   646 NDIIRDNDEICRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEKDNLIKGAN--LTEHALK 708

  Fly  1146 IAE----DVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANC 1206
            |.|    |.....:..|.|               .:...||.:..:.|.:...:      |..:.
  Fly   709 ILESKLRDKRNAVTSDENP---------------ILSAVNPNVPLHDSSRDVFD------GEIDI 752

  Fly  1207 DKHQAGYC-------NGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPI-TTERSDTVI-VAATVSA 1262
            :.:..|:.       |..|.|.:.|         .|..|....:.|| :....|..: :.....|
  Fly   753 NSNYTGFLEIIVRDRNNALMAYSKY---------FDIITPATEAEPIQSLNNMDYYLSIGVKAGA 808

  Fly  1263 VLL-VAMVLVVVYCQH--RCQLIRRASKLARMQDELAALPEG--------YITPNR-------PV 1309
            ||| |.:|.:|::..|  :.:...:......::|.|:....|        :||...       |:
  Fly   809 VLLGVILVFIVLWVFHHKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDAGPI 873

  Fly  1310 HVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQP 1374
            |..|....|:....|:|:.|..|:|.|.:...|:....::|..|..|||:.:|..||.:|.||..
  Fly   874 HRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAV 938

  Fly  1375 VDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCD 1439
            ::....:||||||::.|:...::||..|||:.||.::||||.||.:...|||||...|..:.||.
  Fly   939 INGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCA 1003

  Fly  1440 QYWPVDRV--AMFYGDIKVQLIIDTHYHDWSISEFMVSRNC-------ESRIMRHFHFTTWPDFG 1495
            :||| ::|  ...:|||.|:...:....|:......||:|.       :.|.:..:|:.||.||.
  Fly  1004 KYWP-EKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFM 1067

  Fly  1496 VPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAM 1560
            .||.|..:::|:|....|......||:|||||||||:||.:|||.::|.:.:.|.|.|:..|..:
  Fly  1068 APEHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDL 1132

  Fly  1561 RKERVFMVQTEQQYVCIHQCLLAV-LEGKEHLLAD-------SLELHANDGYEVTKIYLERQPQT 1617
            |.:|.|:||:.:||:.:::.||.. ..|...:..|       ||:...|:|    |..||
  Fly  1133 RHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKPNEG----KCKLE----- 1188

  Fly  1618 KMGTLPIRASLAMAEKLDADLMTNKDEDEDQEQQQQQ 1654
                :.....||.|:::.......::|:.:.:.:.|:
  Fly  1189 ----VEFEKLLATADEISKSCSVGENEENNMKNRSQE 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	49/234 (21%)
		fn3	708..796	CDD:394996	16/100 (16%)
		fn3	902..978	CDD:394996	14/85 (16%)
		fn3	1013..1092	CDD:394996	16/96 (17%)
		PTP_tm	1127..1247	CDD:465889	19/131 (15%)
		R3-PTPc	1358..1579	CDD:350396	87/229 (38%)
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046	16/57 (28%)
		Ig_3	134..216	CDD:464046	19/99 (19%)
		fn3	237..321	CDD:394996	15/95 (16%)
		FN3	<300..>524	CDD:442628	49/245 (20%)
		PTPc	892..1155	CDD:214550	97/263 (37%)
		PTPc	1186..1449	CDD:214550	7/45 (16%)