Protein Alignment Ptp4E and Ptp52F

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Alignment Length: 1537
• Identity: 347/1537 - (22%)
• Similarity: 570/1537 - (37%)
• Gaps: 342/1537 - (22%)

  Fly   308 GLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDEAYTTSSSFR--VRWEPPRTYSE 370
            |.....|.:.|:..|.....|...|.|....|.|.:...||   ||:..|||  |..:||.:
  Fly    58 GFSISNEADYSIDKVICRNGSGSETEANAAHVCENLNPCTF---YTSVVSFRSNVSGKPPPS--- 116

  Fly   371 FDAYQVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPR 435
                                   |...:.|.:..:|..|...||.|
  Fly   117 -----------------------DQTIYAYTEYKQPKTTVTSVVAT------------------- 139

  Fly   436 PVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTL 500
                        :|.:.::|:..:....:|:.|:    ..|::....|      |:..:.:..|.
  Fly   140 ------------ANTIKVTWQTNDRACVESFGIT----AKATDYTKSF------QLLNDKSSQTF 182

  Fly   501 DSLLAGRRYLIAVQALSKG---VASNASDI-TRYTRPAAPLIQELRSIDQGL-MLSWRSDVNSRQ 560
            .:|.|...:.|.:...:..   |.::|:|: |:|..| ..|:..:.::..|: |::| .|.:.:.
  Fly   183 VNLSACLTHTITLDTRNNASVVVDTDATDVDTQYAEP-GDLVMNVTNLASGITMITW-GDPSEKN 245

  Fly   561 --DRYEVHYQRN--GTREERTMATN----ETSLTIHYL----------HPGSGYEVKVHAISHGV 607
              ..|...:|||  ||.:.:...|:    ||:..|.|:          .|..  |||........
  Fly   246 CISNYVFKWQRNDCGTDQNQDTTTDVPSTETTNEIDYVTTTPMETTPDTPSD--EVKCEWTDVSS 308

  Fly   608 RSEPHSY------------FQ-----------------------AVFPKPPQNLTLQTVHTNLVV 637
            ..:...|            ||                       ||:...|.....|
  Fly   309 DGKLREYLLTDLQGCDLYTFQVFINENSTAKASQTFTSAEKLVSAVYEPSPTAYPTQ-------- 365

  Fly   638 LHWQAPEGSDFSEYVVRYR-TDASPWQRISG------LHENEARIKDMHYGERYLVQV--NTVSF 693
            |||......:..:.|..|. |...|.||...      ..|..|...|:.....|||::  |.::
  Fly   366 LHWTWFSPQNHPKCVANYSVTLTGPIQRSENKTMNVITEETFAIFDDLDPCGIYLVEIVPNQLN- 429

  Fly   694 GVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLE--WPRP---DGHVDFYTLKWWPTD------E 747
            |.......|.:.....||.....|:|::...::|  |..|   |..:|.|.|..|..|      |
  Fly   430 GSAGTKYQEQSTVGEDQPSVIQDPVVEAEAYSMEVSWKTPEYADLCIDGYRLSGWMEDDKLVEVE 494

  Fly   748 EDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFI 812
            ...:..:|.|.:.|.:..:.::.|..:.|..:...:.|....|:.:....:....:.|     .:
  Fly   495 ALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYTKVKL-----EM 554

  Fly   813 ANAGHEQGQDETITLSYT---PTPADSTRFDIYRFSMGDPTIKDKEKLANDTER----------K 864
            .|||.|..........|.   ||        |:.....:.|.:.:...|   ||          .
  Fly   555 KNAGSEFIDLIAFNADYNNSCPT--------IFALFTCNATTQVRNPYA---ERYVEGHSKQGFN 608

  Fly   865 LSFSGLTPGKLY--NVTVWTVSGGVASLPV----QRLYRLHPLPISDLKAIQVAAREITLHWTAP 923
            .|.|.|:|...|  .|.::.|:|  .|.||    .......|.....:...:.....:..:|..|
  Fly   609 ASLSPLSPYATYVCKVILYNVAG--PSEPVVDADMHTTTYFPEQPESVMLEKSTVSSLLFNWQPP 671

  Fly   924 AGEYTDFELQYLSA---DEEAP-------QLLQNVTK-----NTEITLQGLRPYHNYTFTVVVRS 973
            .  ||:..::|..|   ..||.       .:::..||     :..:...||.|...|...|..::
  Fly   672 T--YTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSVNFTGLAPAVRYMMQVAAQN 734

  Fly   974 GSIQGTDFADVSVSTLMRSSAPISASYQTLTA-PPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGP 1037
            ....|.....|...||    ..:|.|...||. ..|.|:   .:.|....||..|.: |.:.:|.
  Fly   735 DFGMGVYTEPVIGITL----PAVSDSVTQLTVLTQGPVN---NNAVYEANVTITWKV-PCKSNGD 791

  Fly  1038 IDYFRITCQNADDAADVSSYEFPVNATQGKIDG--------LVPGNHYIFRIQAKSALGYGAERE 1094
            |:||::......:.....|:|..|....|...|        :.|...|...:..|:     .:.|
  Fly   792 IEYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQPQFDYTVEVSVKN-----RDVE 851

  Fly  1095 HIQT-------MPILAPPVPEPSVTPL------EVSRTSSTIEISFRQGYFSNAHGMVRSYTIII 1146
            .:.:       .|...|.:|...:...      |.|..:.|..:.......::|.|.::...::|
  Fly   852 QLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEETSNPTKTAIVRLPADIMTSASGDIKWMALMI 916

  Fly  1147 AEDVGKNASGLE------MPSWQDVQAY---------TVWLPYQAIEP-YNPFLTSNGSRKSSLE 1195
            ::   ||.:|:.      ...|..|.:|         ...|.||..|. ::|.......|...:.
  Fly   917 SQ---KNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEERWHPEPVQRQRRDGEVT 978

  Fly  1196 AEH---FTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVA 1257
            ::.   ||||...|.:.|..||||||...|.|.:.:|.|| ...::|....:..|.......::.
  Fly   979 SDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNVVVRLFT-ASGYSDAAVLNFKTKAAIKVTLIL 1042

  Fly  1258 ATVSAVLLVAMV--LVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRI 1320
            .:|.:.||:|.|  |.|::.:.|         ||..:|.    .:|...|...|..|:|:..|..
  Fly  1043 VSVCSCLLLAFVLGLTVLWVRKR---------LAWKRDS----GQGIEDPFGNVIAKNFAIFYTE 1094

  Fly  1321 MSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYIN 1385
            ::...  :.:.||:|:..|..:.:.|.:.|.|:  |||:.:|.|||.:|..|.  .|.:||||||
  Fly  1095 VAKPE--KLAREFKEITVVALELSYSASELGCH--KNRYADIFPYDKNRVILD--IDAEGSDYIN 1153

  Fly  1386 ANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMF 1450
            |:::.||...:|:|.||||...:..:||||..:.|.|.||.:|:..|....||.:|:|.: |...
  Fly  1154 ASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN-VRGL 1217

  Fly  1451 YGDIKVQLIID-------THYHD-WSISEFMVSRNCESRIMRHFHFTTWPDFGVPEPPQSLVRFV 1507
            ...||.:.:::       |..|| :.:.|.::          |::|..|||.||||.|..|:.||
  Fly  1218 TVTIKSKEVLELYDRTELTVVHDKYGLKEKVI----------HYYFKKWPDHGVPEDPMHLIMFV 1272

  Fly  1508 RAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQ 1572
            :..:........||:|||||||||:||||.||.|:|.:.....::||..|..:|.:|:.||||:|
  Fly  1273 KKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQ 1337

  Fly  1573 QYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKMGTLPIRASLAMAEKLDAD 1637
            ||..::.|...:::                 :::.:..|:...:.|..|:|...|.......|.|
  Fly  1338 QYTFLYACTYELVK-----------------HKIPRAALKMDGRPKSVTVPAIPSPKKVSFPDVD 1385

  Fly  1638 L---------MTNKDEDEDQEQQQQQQLQLATEVKPKGSNDD 1670
            :         :|:.|:.....|...:...|... .|.|.||:
  Fly  1386 VGSEYVSSAPITDLDDGRPIVQLPSRFSGLRRN-SPPGENDN 1426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	6/25 (24%)
		fn3	247..328	CDD:394996	4/19 (21%)
		FN3	319..>749	CDD:442628	99/509 (19%)
		fn3	708..796	CDD:394996	21/98 (21%)
		fn3	902..978	CDD:394996	15/90 (17%)
		fn3	1013..1092	CDD:394996	17/86 (20%)
		PTP_tm	1127..1247	CDD:465889	33/138 (24%)
		R3-PTPc	1358..1579	CDD:350396	88/228 (39%)
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	18/102 (18%)
		PTPc	1100..1345	CDD:214550	97/259 (37%)