Protein Alignment Ptp4E and IA-2

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Alignment Length: 1443
• Identity: 299/1443 - (20%)
• Similarity: 507/1443 - (35%)
• Gaps: 427/1443 - (29%)

  Fly   517 SKGVASNASDITR-----YTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREER 576
            ::|.|.:....|.     :::...|..|:.:..||......:...::.|:  .||:.|:..:.|.
  Fly    37 ARGTAGHQESATGECQQFWSKQRPPFDQQQQQEDQDPEQDPQQHPSTPQE--SVHHHRSPRQHEL 99

  Fly   577 TMATNETSLTIHYLHPGSGYEVKVHAISHGVR----------------------SEPHSYFQ--- 616
            .....:...|:    |..|.    |.||.|.|                      |.|....|
  Fly   100 LHHQRKVPPTL----PARGR----HLISEGARRREVRGCGAGGGGLLCCSLDALSRPAKLLQFGV 156

  Fly   617 ----------AVFPKPPQNLTLQTVHTNLVVLHWQ-APEGSDFSEYVVRYRTDASPWQRISGLHE 670
                      ....:...|:..|.|.| |.:.|.: ..:.:.|.:.:.....|....:: :.|.|
  Fly   157 LLLILLLATHGDLAQAEGNVGCQFVRT-LCIPHSEVCYDDNIFGKCIPTTGVDVEDIEK-TPLTE 219

  Fly   671 NEARIKDMHYGERYLVQVNTVSFGVESPH----------PLELNVTMPPQPVSNVVPLVDS---- 721
            :::|:.     ...|.::.....|.:.|:          .|:....:||...:|:.|....
  Fly   220 DQSRVL-----ATMLEELQGAGLGWDHPYVQCRIQGSLFSLQRQQQLPPNLCANLAPTPPEFGDP 279

  Fly   722 ----RNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRF 782
                ..:....|.|:..:|:|.....|......:..|.|.:.:          .:|:     |..
  Fly   280 ASALAYVRFTPPEPEAELDYYEQPAGPAQFYPALRKKQVRESD----------ADDM-----YLN 329

  Fly   783 EVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMG 847
            .:......:|...:.|          :.|....||.|                ||:.|.
  Fly   330 RMLQDRRRLRHDPSEL----------EHFGKMDGHGQ----------------STQLDA------ 362

  Fly   848 DPTIKD------------KEKLA---NDTERKLSFSGLTPGKLYNVTVWTVSGGVAS----LPVQ 893
             |:|.|            :::||   .|.:|:...:.|   :||.:.       .||    .|.|
  Fly   363 -PSIMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRL---ELYQIL-------AASEPDPQPYQ 416

  Fly   894 RLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLL--QNVTKNTEI-- 954
            |.....|..:..|:||              ..:....||:......:||..:  :.|.:::|:
  Fly   417 RKPAAQPNAMDQLEAI--------------VEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYF 467

  Fly   955 --------------------TLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISAS 999
                                .::..:|..::...:....|.:|........|.|      .:.|:
  Fly   468 PDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVET------EVDAT 526

  Fly  1000 YQTLTAPPGKVDYFQPSDV--QPGEVTFEW-----SLEPAEQHGPIDYFRITCQNADDAADVSSY 1057
            .:.:...|.......|.||  |..|:.||.     ||.|.|:.                |.::|.
  Fly   527 PELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEE----------------AMLASN 575

  Fly  1058 EFPVNA------TQGKI----------DGL---VPGNHYIFRIQAKSALGYGAEREHIQTM---P 1100
            .||..|      |:|.:          ||:   .|.|  :.:....:.||: |..|.:...   |
  Fly   576 SFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPEN--VKQSLLANMLGF-ARHERLDVKKPGP 637

  Fly  1101 ILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFS--------------NAHG----MVRSYTIIIA 1147
            :|.|    ||:...|:|....|.:...::|:.:              :||.    |.:.::   |
  Fly   638 LLGP----PSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHS---A 695

  Fly  1148 EDVGKNASGLE---------MPSWQD-------------VQAYTVWLPYQAIEPYNPFLTSNGSR 1190
            ||...:....|         :.||.|             :|.|..:|..|..|......::|..|
  Fly   696 EDHAPHTVDTEYVHVFVKNPIDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPER 760

  Fly  1191 KSSLEAEHFTI----GTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSS------- 1244
            |::.:... ||    |..|..:.:.|:.  .|.||....||       |....:|.||
  Fly   761 KTAGDVAR-TINENRGVKNNIQRRVGFY--VLHAGVGDVIK-------DLQDPSVSSSRIELAEQ 815

  Fly  1245 -PITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAA----------- 1297
             |..|.....:...|..:||:::.:.|:::. :|.    |:..||..:|..:|.
  Fly   816 GPDVTHIMAYMFAGAGAAAVIVIFVTLILIK-RHD----RKRDKLGGLQSGIAGAETCSKDYQEL 875

  Fly  1298 ---------------------------LPEGYIT------PNRPVHVK---------------DF 1314
                                       .|.|.||      ..||...:               |.
  Fly   876 CRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDI 940

  Fly  1315 SEHYRIMSADSDF-----RFSEEFEEL-KHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQ 1373
            |..:.::|...|.     |...|:|.| ::.....|...|:.|.....||....|||||||..|.
  Fly   941 STGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLN 1005

  Fly  1374 PVDDDDGSDYINANYMPGHNSPR--EFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGRE 1436
            .:.:.:|.||:||:.:..|: ||  .::..||||.||...||:|.||..:..||.|.|..|.|..
  Fly  1006 HLANAEGLDYVNASTITDHD-PRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEV 1069

  Fly  1437 KCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVS-------RNCESRIMRHFHFTTWPDF 1494
            .|.:||| :..|..|...:|.|:.:   |.| ..:::|.       |..|:|.:..|||.:||..
  Fly  1070 ACARYWP-EEGAEVYHIYEVHLVSE---HIW-CDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHM 1129

  Fly  1495 GVPEPPQSLVRFVR----AFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHK-SDYVDIF 1554
            |||...::|:.|.|    ::|   |....||:||.|||.||:|.:|.||.:|:.::| :..:||.
  Fly  1130 GVPAQAKALLDFRRKVNKSYR---GRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIA 1191

  Fly  1555 GIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKM 1619
            ..:..:|.:|..:|.|.||:..:   |:||.| :.|.:..:|.  ||...|  |..|::.|....
  Fly  1192 ATLEHLRDQRAGVVATRQQFEFV---LMAVAE-EVHAILKALP--ANTSGE--KRELDKDPVVGG 1248

  Fly  1620 GTLPIRASLAMAEKLDADLMTNKDEDEDQEQQQQQQLQLATEVKPKGSNDDEEDEEDDDDDDDDQ 1684
            |:    :|....|.|        .||:.||..:::....:::.......:.|:|::.::....||
  Fly  1249 GS----SSTTTKEPL--------KEDKAQEAAEEEAPTSSSKAAAAAKKEKEKDKDKEEKQAKDQ 1301

  Fly  1685 QPLNNETTATLSS 1697
            ..:....|...|:
  Fly  1302 AKVAEPRTPAKSA 1314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	47/290 (16%)
		fn3	708..796	CDD:394996	14/95 (15%)
		fn3	902..978	CDD:394996	11/99 (11%)
		fn3	1013..1092	CDD:394996	24/104 (23%)
		PTP_tm	1127..1247	CDD:465889	34/171 (20%)
		R3-PTPc	1358..1579	CDD:350396	84/234 (36%)
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	20/92 (22%)
		PTP_DSP_cys	942..1225	CDD:475123	99/295 (34%)