Protein Alignment Ptp4E and PTPN18

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_006712480.1
• Gene: PTPN18 / 26469
• HGNCID: 9649
• Length: 464
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 96/285 - (33%)
• Similarity: 141/285 - (49%)
• Gaps: 39/285 - (13%)

  Fly  1322 SADSDFRFSEEFEELKHVGRD-----------QACSFA------------NLPCNRPKNRFTNIL 1363
            |.||...|.|..|  ...||:           ||||.|            :.|.|..|||:.::|
Human     4 SLDSARSFLERLE--ARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYKDVL 66

  Fly  1364 PYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLT 1428
            |||.:|..|..:.::..|||||.|::.|.:....:|.|||||..|..:|||:.||...:.|:|..
Human    67 PYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMAC 131

  Fly  1429 RCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFM-----VSRNCESRIMRHFHF 1488
            |..|.||::|::||..::..:..|...:.||.:    .|...:.|     |:...|||.:....:
Human   132 REIENGRKRCERYWAQEQEPLQTGLFCITLIKE----KWLNEDIMLRTLKVTFQKESRSVYQLQY 192

  Fly  1489 TTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRI----LQHIHKSD 1549
            .:|||.|||..|..::..|...|.:.|:...|:.||||||.||:|....:|.:    |..:...|
Human   193 MSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPD 257

  Fly  1550 YVDIFGIVFAMRKERVFMVQTEQQY 1574
            : .:|.:|..|||:|...||||:||
Human   258 F-SLFDVVLKMRKQRPAAVQTEEQY 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628
		fn3	708..796	CDD:394996
		fn3	902..978	CDD:394996
		fn3	1013..1092	CDD:394996
		PTP_tm	1127..1247	CDD:465889
		R3-PTPc	1358..1579	CDD:350396	79/226 (35%)
PTPN18	XP_006712480.1	PTPc-N18	27..292	CDD:350451	88/260 (34%)