Protein Alignment Ptp4E and Ptprz1

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_037212.2
• Gene: Ptprz1 / 25613
• RGDID: 3455
• Length: 2316
• Species: Rattus norvegicus
• Alignment Length: 1959
• Identity: 439/1959 - (22%)
• Similarity: 681/1959 - (34%)
• Gaps: 640/1959 - (32%)

  Fly   116 KFSRALPGTEYNFWLYYTNSTHREQLTWTVNITTAPDPPANLSVQLRSSKSAFITWRPPGSGRYS 180
            ||||.:          :::.|.:|:    ::.......|.|:.....:..|..|||..|
  Rat   291 KFSRQV----------FSSYTGKEE----IHEAVCSSEPENVQADPENYTSLLITWERP------ 335

  Fly   181 GFRIRVLGLTDL--------PFE------RSYSLEGNETLQLSAKELTPGGSYQVQAYSVYQGKE 231
                ||:..|.:        |.|      ..:..:|.:.|......|.|..||.:|..::...
  Rat   336 ----RVVYDTMIEKFAVLYQPLEGNDQTKHEFLTDGYQDLGAILNNLIPNMSYVLQIVAICSN-- 394

  Fly   232 SVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYR----VSITPDDAIQSVLYV 292
                                                   |:|..|.    |.:..:|| :..|:.
  Rat   395 ---------------------------------------GLYGKYSDQLIVDMPTEDA-ELDLFP 419

  Fly   293 EREG-------EPPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPTTARYLTVPERVLNVTFDE 350
            |..|       |..|.......||.|||:   |.......:...|.||..|     ..:...::|
  Rat   420 ELIGTEEIIKEEDYGKGNEEDTGLNPGRD---SATNQIRKKEPQVSTTTHY-----NHMGTKYNE 476

  Fly   351 AYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVK 415
            |.|..|        |...|||.....:|:||                      |.|  |.:.|.:
  Rat   477 AKTNRS--------PTKGSEFSGKSDVLNTS----------------------LNP--TSQQVAE 509

  Fly   416 TIADNVNSWPASGEVTLRPRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNASEVP 480
            ...:...|.|:.....|.|..|......|:..|..|.:..:...:|..:|  ::....|...||.
  Rat   510 FNPEREMSLPSQIGTNLPPHSVEGTSASLNSGSKTLLVFPQMNLSGTAES--LNMVSITEYKEVS 572

  Fly   481 APFPVAAESQITTNLTEYTLD--------SLLAGRRYLIAVQALSKGVASNAS-------DITR- 529
            |..     |:....||::.||        |..|......:...||.|..|::.       |:.|
  Rat   573 ADL-----SEEENLLTDFKLDSGADDSSGSSPASSTVPFSTDNLSHGYTSSSDTPEAVTYDVLRP 632

  Fly   530 -YTRPA----APLIQELRSIDQGLM----------LSWRSDVNSRQDRYEVHYQRNGT--REERT 577
             .||.|    ||...|....|..|.          |:.:|:..|.::.:   .|.|.|  :.:.:
  Rat   633 ESTRNALEDSAPSGSEESLKDPSLEGSVWFPGSTDLTTQSETGSGREGF---LQVNSTDFQVDES 694

  Fly   578 MATNET-----------SLT----IHY---LHPGSGYEVKVHA---------------ISHGVRS 609
            ..|.||           |:|    .||   .:|.:  ||..||               |.|...:
  Rat   695 RETTETFSPDATASRGPSVTDMEMPHYSTFAYPPT--EVTPHAFTPSSRPLDLAPTSNILHSQTT 757

  Fly   610 EP---------HSYFQAVFP-KPPQNLTLQTVHTNLV------VLHWQAP----EGSDFSEYVVR 654
            :|         .||...||| ..|..|..||::|...      .|| ..|    .|..|...:..
  Rat   758 QPVYNGETPLQPSYSSEVFPLVTPLLLDNQTLNTTPAASSSDSALH-ATPVFPSVGVSFDSILSS 821

  Fly   655 YRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVE-SPHPLEL----NVTMPPQPV-- 712
            |  |.:|....|....:......:|...:.|.||.:.:...| |.|...|    ::.:.|..|
  Rat   822 Y--DDAPLLPFSSASFSSDLFHHLHTVSQTLPQVTSAAERDELSLHASLLVAGGDLLLEPSLVQY 884

  Fly   713 SNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKN--VTQLEDLSSPSVRIPIEDLS 775
            |:|:    |..:|:       |....||::   ..|..|.:|.  |:|:|   |||..:.:...|
  Rat   885 SDVM----SHQVTI-------HAASDTLEF---GSESAVLYKTSMVSQIE---SPSSDVVMHAYS 932

  Fly   776 PGRQYRFEVQAS----------------SNGIRS------GTTHLS-------TRTMPLIQSDVF 811
            .|.:..:.::.|                |.|:..      ..:|:|       |.|..|:|....
  Rat   933 SGPETSYAIEGSHHVLTVSSSSAIPVHDSIGVADQGSLLINPSHISLPESSFITPTASLLQLPPA 997

  Fly   812 IANAGHEQGQD-------------ETITLSYTPTPADSTRFDIYRFSM-GD---PTIKDKEKLAN 859
            ::..|...|..             .|:.:|...:.||.|    |..|: ||   |..|.:....|
  Rat   998 LSGDGEWSGASSDSELLLPDTDGLRTLNMSSPVSVADFT----YTTSVSGDDIKPLSKGEMMYGN 1058

  Fly   860 DTERKL-SFSGL--------TPGKLYNVTVWT-----VSGGVASL----------PVQRLY--RL 898
            :||.|: |||.:        .|.....|..|:     .|..|:|:          |:.:::  .:
  Rat  1059 ETELKMSSFSDMAYPSKSTVVPKMSDIVNKWSESLKETSVSVSSINSVFTESLVYPITKVFDQEI 1123

  Fly   899 HPLP--ISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLLQNVTK----------N 951
            ..:|  |..:|....|::.....|..| |..|:.|...  :|..:.::|...|:          |
  Rat  1124 SRVPEIIFPVKPTHTASQASGDTWLKP-GLSTNSEPAL--SDTASSEVLHPSTQPLLYEAASPFN 1185

  Fly   952 TEITLQGLRPYHN-----------------YTFT-VVVRSGSIQGTDFADVSV---STLMRSSAP 995
            ||..||...|..:                 .|.| :|.:|.|......|..|.   |||..:|.|
  Rat  1186 TEALLQPSFPASDVDTLLKTALPSGPRDPVLTETPMVEQSSSSMSLPLASESASSKSTLHFTSVP 1250

  Fly   996 I---------SASYQTLTAPPGKVDYFQ--------PSDVQP----------------------- 1020
            :         ..|.|.||.|..:.:||:        |..|.|
  Rat  1251 VLNMSPSDVHPTSLQRLTVPHSREEYFEQGLLKSKSPQQVLPSLHSHDEFFQTAHLDISQAYPPK 1315

  Fly  1021 GEVTFEWSL----EP---------------------------------------AEQH------G 1036
            |...|...:    ||                                       |..|      |
  Rat  1316 GRHAFATPILSIDEPQNTLISRLVYSEDIFMHPEISITDKALTGLPTTVSDVLIATDHSVPLGSG 1380

  Fly  1037 PIDYFRITCQNADDAA-----------------------------------------DVSSYEFP 1060
            ||....:: .|.||:.                                         |:.|..||
  Rat  1381 PISMTTVS-PNRDDSVTTTKLLLPSKATSKPTHSARSDADLVGGGEDGDDYDDDDYDDIDSDRFP 1444

  Fly  1061 VN---------ATQGK------------IDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAP 1104
            ||         .:|.|            :|...|.:|.:.....:...|.|..|  :...|..:|
  Rat  1445 VNKCMSCSPYRESQEKVMNDSDTQESSLVDQSDPISHLLSENTEEENGGTGVTR--VDKSPDKSP 1507

  Fly  1105 PVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASG------------- 1156
            |   ||:.|.:.:......:|........:..|. :::.::.:::...:..|
  Rat  1508 P---PSMLPQKHNDGREDRDIQMGSAVLPHTPGS-KAWAVLTSDEESGSGQGTSDSLNDNETSTD 1568

  Fly  1157 LEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAG 1221
            ...|...:..|..|      :|..:..:.....|.|:........|.:|..:.:|...:...|.|
  Rat  1569 FSFPDVNEKDADGV------LEADDTGIAPGSPRSSTPSVTSGHSGVSNSSEAEASNSSHESRIG 1627

  Fly  1222 TTYRIKIRAFTDEDKFTDTVYSSPITTERSDTV--IVAATVSAVLLVAMVLVVVYCQHRCQLIRR 1284
                                .:..:.:|:...:  ::.:.::.:.||.:|.:::|.       |:
  Rat  1628 --------------------LAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYW-------RK 1665

  Fly  1285 ASKLARMQDELAALPEGYITPNRPVH----------VKDFSEHYRIMSADSDFRFSEEFEELKHV 1339
            ..:.|....|....|....||..|:.          :|.|.:|...:.|.:.  |:||||.||..
  Rat  1666 CFQTAHFYLEDNTSPRVISTPPTPIFPISDDIGAIPIKHFPKHVADLHASNG--FTEEFETLKEF 1728

  Fly  1340 GRD-QACSF--------ANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDG--SDYINANYMPGHN 1393
            .:: |:|:.        :|.|.|:.|||:.||:.|||||.||..:.:.||  :|||||||:.|:|
  Rat  1729 YQEVQSCTVDLGITADSSNHPDNKHKNRYVNIVAYDHSRVKLTQLAEKDGKLTDYINANYVDGYN 1793

  Fly  1394 SPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDI---- 1454
            .|:.:|..||||.||.|:||||.||.|...|||:|...||||.|||||||.|. :..||..
  Rat  1794 RPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPTDG-SEEYGSFLVNQ 1857

  Fly  1455 -KVQLIIDTHYHDWSISEFMVSRNCE-----SRIMRHFHFTTWPDFGVPEPPQSLVRFVR----A 1509
             .||::......::::....:.:..:     .|::..:|:|.|||.||||....::.|||    |
  Rat  1858 KNVQVLAYYTVRNFTLRNTKIKKGSQKGRSSGRLVTQYHYTQWPDMGVPEYSLPVLAFVRKTAQA 1922

  Fly  1510 FRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQY 1574
            .|..:|    |::|||||||||:||:|.||.:||.|.....|:|||.:..:|.:|.::||||:||
  Rat  1923 KRHAVG----PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQY 1983

  Fly  1575 VCIHQCLLAVLEGKEHLLADSLELHANDGYEVT--------KIYLERQPQTKMGTLPIRASLAMA 1631
            |.||..|:..:..||..:.|| .:|:   |..|        |..||:|.|.          |:.:
  Rat  1984 VFIHDTLVEAILSKETEVPDS-HIHS---YVNTLLIPGPSGKTKLEKQFQL----------LSQS 2034

  Fly  1632 EKLDADLMT 1640
            ..|.:|..|
  Rat  2035 NILQSDYST 2043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	44/242 (18%)
		fn3	247..328	CDD:394996	17/91 (19%)
		FN3	319..>749	CDD:442628	111/522 (21%)
		fn3	708..796	CDD:394996	23/113 (20%)
		fn3	902..978	CDD:394996	23/105 (22%)
		fn3	1013..1092	CDD:394996	29/220 (13%)
		PTP_tm	1127..1247	CDD:465889	13/132 (10%)
		R3-PTPc	1358..1579	CDD:350396	105/236 (44%)
Ptprz1	NP_037212.2	alpha_CARP_receptor_like	45..298	CDD:239396	4/16 (25%)
		fn3	313..401	CDD:394996	21/138 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..499		20/81 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	518..537		4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	586..624		8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	636..720		18/86 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1141..1172		7/33 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1204..1228		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1401..1521		20/124 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1545..1622		10/82 (12%)
		PTP_DSP_cys	1718..1995	CDD:475123	121/281 (43%)
		R-PTP-Z-2	2078..2281	CDD:350507