Protein Alignment Ptp4E and Ptpro

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_036021846.1
• Gene: Ptpro / 19277
• MGIID: 1097152
• Length: 1261
• Species: Mus musculus
• Alignment Length: 1345
• Identity: 332/1345 - (24%)
• Similarity: 530/1345 - (39%)
• Gaps: 386/1345 - (28%)

  Fly   445 DDRSNALHISWEPAE------------TGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTE 497
            ||  |.:.:|.|.::            .|...:|...:.|..:....|..|.....
Mouse    71 DD--NNIVVSLEASDIVSPASVYVVRVAGESKNYFFEFEEFNSTLPPPVVFKATYH--------- 124

  Fly   498 YTLDSLLAGRRYLIAVQALSKGVASNAS-DITRYTRP----AAPLIQELRSIDQGLMLSWRSDVN 557
                    |..|:|.:..::..|.:..| .||..|:|    :..:.....|.:.|::
Mouse   125 --------GLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVL-------- 173

  Fly   558 SRQDRYEVHYQRNGT------------REERTMATNE----TSLTIHYLHPGSGY-EVKVHAISH 605
                 :|:||.....            |:.|||...:    .::..|:| ||..| .:....:|.
Mouse   174 -----FEIHYPEKYNVFSRVNISYWEGRDFRTMLYKDFFKGKTVFNHWL-PGLCYSNITFQLVSE 232

  Fly   606 ------------GVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTD 658
                        ||..||..:..|  |.||:|::::.|  ||...:|:.|.||...:..::...|
Mouse   233 ATFNKSTLVEYSGVSHEPKQHRTA--PYPPRNISVRFV--NLNKNNWEEPSGSFPEDSFIKPPQD 293

  Fly   659 ASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNVTMPPQPVSNVVPLVDSRN 723
            :.            .|.:..|:.|             |:|.       .||..||:..|   ..|
Mouse   294 SI------------GRDRRFHFPE-------------ETPE-------TPPSNVSSGSP---PSN 323

  Fly   724 LTLEWPRPDGHVDFYTLK---WW------PTDEEDRV-----EFKNVTQLEDLSSPSV----RIP 770
            ::..||.|:. .|:.:..   ||      |.:|||.|     ::...|.|:....|:.    ..|
Mouse   324 VSSAWPDPNS-TDYESTSQPFWWDSASAAPENEEDFVSALPADYDTETTLDRTEKPTADPFSAFP 387

  Fly   771 IE------------------------------------------DLSPGRQYRFEVQA-SSNGIR 792
            ::                                          :|....:|:..|.. ||:|..
Mouse   388 VQMTLSWLPPKPPTAFDGFNILIEREENFTDYLTVDEEAHEFVAELKEPGKYKLSVTTFSSSGAC 452

  Fly   793 SGTTHLSTRTMPLIQSDVFIANAGH------EQGQ--------DETITLSYTPTPADSTRFDIYR 843
            ......|.:::     ..:|:..|.      |:.|        ..|..:|:|.:..:.....:..
Mouse   453 ETRKSQSAKSL-----SFYISPTGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSV 512

  Fly   844 FSMGDPTIKDKEKLAND-----TERKLSFSGLTPGKLYNVTVWTVSG---GVASLPVQRLYRLHP 900
            .|:.....|:.::|...     ...|.....|.||..|.|.::...|   |..|.||  .:.:.|
Mouse   513 VSLTCQKQKESQRLEKQYCTQVNSSKPVIENLVPGAQYQVVMYLRKGPLIGPPSDPV--TFAIVP 575

  Fly   901 LPISDLKAIQVAAREITLHWTAP-AGEYTDF--ELQYLSADEEAP------QLLQNVTKNTEITL 956
            ..|.||....:....:.|.||.| .|.:..:  |:.|.:......      ::...|:....:.:
Mouse   576 TGIKDLMLYPLGPTAVVLSWTRPILGVFRKYVVEMFYFNPTTMTSEWTTYYEIAATVSLTASVRI 640

  Fly   957 QGLRP--YHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQ 1019
            ..|.|  |:|:..|:|.         :.|..:|..  .|:.||    .:|||           |.
Mouse   641 ASLLPAWYYNFRVTMVT---------WGDPELSCC--DSSTIS----FITAP-----------VA 679

  Fly  1020 PGEVTFEWSLEPAEQHGPIDYFR----ITCQNADDAADVS---SYEFPVNATQGK---------- 1067
            | |:|            .::||.    |:....|...|:|   ...:.|.|...|
Mouse   680 P-EIT------------SVEYFNSLLYISWTYGDATTDLSHSRMLHWMVVAEGRKKIKKSVTRNV 731

  Fly  1068 ---IDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISF-R 1128
               |..|.||:.|...:.|.:      ||....::|.|....|.|..:...|::|.:::.:.: .
Mouse   732 MTAILSLPPGDIYNLSVTACT------ERGSNTSLPRLVKLEPAPPKSLFAVNKTQTSVTLLWVE 790

  Fly  1129 QGYFSNAHGMVRSYTIIIAEDVGKNASG-LEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKS 1192
            :|        |..:..:..:.:|...:| |:.|  ..|.::.|
Mouse   791 EG--------VADFFEVFCQQLGSGHNGKLQEP--VAVSSHVV---------------------- 823

  Fly  1193 SLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDT-VYSSPITTERSDTVIV 1256
                   ||.:              |...|.|...:.:|:.:.....| :..|.:.||.:..|:|
Mouse   824 -------TISS--------------LLPATAYNCSVTSFSHDTPSVPTFIAVSTMVTEVNPNVVV 867

  Fly  1257 AATVS--AVLLVAMVLV--VVYCQHRCQLIRRAS-----KLARMQDE--------------LAAL 1298
            .:.::  :.||:.::||  |:..:...|:.|...     ..|.::.|              |..|
Mouse   868 ISVLAILSTLLIGLLLVTLVILRKKHLQMARECGAGTFVNFASLEREGKLPYSWRRSVFALLTLL 932

  Fly  1299 PE---------GYITP-----------NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQ 1343
            |.         .||.|           ..||.:.||..:.:.|:.|||::||.:|||||.:|.|.
Mouse   933 PSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDSYIKDMAKDSDYKFSLQFEELKLIGLDI 997

  Fly  1344 ACSFANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHST 1408
            ....|:||.||.|||:|||||||.||.:|..:::::|:|||||||:||:|||:|:|.|||||..|
Mouse   998 PHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPET 1062

  Fly  1409 REEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFM 1473
            |.:||:|..:..|..|||||:|.||.|.|||.|||.....:.||||.|:::.:....||:...|.
Mouse  1063 RNDFWKMVLQQKSHIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMVSEEEEEDWASRHFR 1127

  Fly  1474 VSRNCESRIMRHFHFTTWPDFGVP--EPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFI 1536
            ::...|::.:.||::|.|||.|||  ...:|:::||...|........|:|:||||||||:||||
Mouse  1128 INYADEAQDVMHFNYTAWPDHGVPPANAAESILQFVFTVRQQAAKSKGPMIIHCSAGVGRTGTFI 1192

  Fly  1537 ALDRILQHIHKSDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCL 1581
            ||||:||||...::|||.|:|..||..|:.|||||:||:.||||:
Mouse  1193 ALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	70/358 (20%)
		fn3	708..796	CDD:394996	27/148 (18%)
		fn3	902..978	CDD:394996	17/86 (20%)
		fn3	1013..1092	CDD:394996	19/98 (19%)
		PTP_tm	1127..1247	CDD:465889	16/122 (13%)
		R3-PTPc	1358..1579	CDD:350396	112/222 (50%)
Ptpro	XP_036021846.1	FN3	479..571	CDD:238020	19/93 (20%)
		FN3	575..675	CDD:238020	23/114 (20%)
		fn3	770..850	CDD:394996	17/132 (13%)
		R-PTPc-O	996..1240	CDD:350462	123/242 (51%)