Protein Alignment Ptp4E and Ptprn2

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_035345.2
• Gene: Ptprn2 / 19276
• MGIID: 107418
• Length: 1001
• Species: Mus musculus
• Alignment Length: 1435
• Identity: 298/1435 - (20%)
• Similarity: 456/1435 - (31%)
• Gaps: 561/1435 - (39%)

  Fly   260 LLVLWQPPFPAGIYTHYRVSITPDDAIQSVLYVEREGEPPGPAQAAFKGLVPGR-----EYNI-- 317
            ||:|..||.|..:                          |.||.|..:.| |||     |..:
Mouse     9 LLLLLPPPLPRAL--------------------------PAPASARGRQL-PGRLGCLFEDGLCG 46

  Fly   318 SVQTVSED----ETSSVPT--TARYLTVPERVLN--VTFDEAYTTSSSFRVRWEPPRTYSEFDAY 374
            |::|...|    ....||.  |.||...|..:|:  ||..:...|..:    |:.
Mouse    47 SLETCVNDGVFGRCQKVPVMDTYRYEVPPGALLHLKVTLQKLSRTGFT----WQD---------- 97

  Fly   375 QVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRS 439
                                    ||        |..|:.:.:|:...::...||.:   .|.||
Mouse    98 ------------------------DY--------TQRVIAQELANLPKAYLWHGEAS---GPARS 127

  Fly   440 LGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLL 504
            |      :.||.:..|                           |.:..|..:...|
Mouse   128 L------QQNADNEKW---------------------------FSLEREVALAKTL--------- 150

  Fly   505 AGRRYLIAVQALSKGVASNA-SDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQ 568
              ||||..::.||:...:|| |.|...||||                       ..:|
Mouse   151 --RRYLPYLELLSQTPTANAHSRIDHETRPA-----------------------KGED------- 183

  Fly   569 RNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNL-----TL 628
                      ::.|..||         |.....|:         :|..|...|.|.||     .|
Mouse   184 ----------SSPENILT---------YVAHTSAL---------TYPPATRAKYPDNLLRPFSRL 220

  Fly   629 QTVHTNLVVLHWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSF 693
            |....:..|       ..|..:..:.....|...||:.|.::.|         .||||.
Mouse   221 QPDELSPKV-------DGDIDKQKLIAALGAYTAQRLPGENDPE---------PRYLVH------ 263

  Fly   694 GVESPHPLELNVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQ 758
                      .....|:|.|       :..|:..||.|.|..     |..|:.::|.:   ..:.
Mouse   264 ----------GSARAPRPFS-------ATALSQRWPPPPGDA-----KDSPSMDDDTL---LQSL 303

  Fly   759 LEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHE----- 818
            |:||...|   .::.|.|.::.:.:..|.:                 ||||.  |....|
Mouse   304 LKDLQQNS---EVDRLGPLKEEKADSVAGA-----------------IQSDP--AEGSQESHGRG 346

  Fly   819 -QGQDETITLSYTPTPADSTRFDIYRFS-MGDPTIKDKEKLA---NDTERKLSFSGLTPGKLYNV 878
             :||..      ..|.|..|....:|.| :.||..|:..:|:   .|..:......|..|.|
Mouse   347 AEGQPR------EQTDAPETMLQDHRLSEVDDPVYKEVNRLSFQLGDLLKDYGSPLLPEGPL--- 402

  Fly   879 TVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQ 943
                                          ::.::||.......|.        :.||::||...
Mouse   403 ------------------------------LEKSSREEIKKSEQPE--------EVLSSEEETAG 429

  Fly   944 LLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQ-------------GTDFADVSVSTLMRSSAP 995
             :::|...|            |:..:..|..:.:             ..:..:...|..:.:..|
Mouse   430 -VEHVRSRT------------YSKDLFERKPNSEPQPRRLEDQFQNRAPELWEDEESLKLAAQGP 481

  Fly   996 ISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFP 1060
            .|...|.              :|||.|          ||.|.|    :|..|            |
Mouse   482 PSGGLQL--------------EVQPSE----------EQQGYI----LTGNN------------P 506

  Fly  1061 VNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEI 1125
            ::..:||  .|:....:|.|:.:          .....:.:|.|.|               |.::
Mouse   507 LSPEKGK--QLMDQVAHILRVPS----------SFFADIKVLGPAV---------------TFKV 544

  Fly  1126 SFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSR 1190
            |      :|...|..:..|..|.|   |...||
Mouse   545 S------ANIQNMTTADVIKAAAD---NKDQLE-------------------------------- 568

  Fly  1191 KSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVI 1255
                :|...||                |::|...:.|::....:::..|:.         ...::
Mouse   569 ----KATGLTI----------------LQSGIRPKGKLKLLPHQEEQEDST---------KFILL 604

  Fly  1256 VAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARM-QDELAALPEGY---ITPNRPVHVKDFSE 1316
            ...:::.:|.|.:...:.||.......:...||:.: .|..|...|.|   ......:..:|.||
Mouse   605 TFLSIACILGVLLASSLAYCLRHNSHYKLKDKLSGLGADPSADATEAYQELCRQRMAIRPQDRSE 669

  Fly  1317 --H-YRIMSADSDF---------------RFSEE------------------FEELKHVGR---- 1341
              | .||.|..|.|               .:|||                  .:.||:..|
Mouse   670 GPHTSRINSVSSQFSDGPMPSPSARSSTSSWSEEPVQSNMDISTGHMILAYMEDHLKNKNRLEKE 734

  Fly  1342 -DQACSFANLPC---------NRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPR 1396
             :..|::...|.         |.||||...:|.|||||..|:..:....||||||:.:..|: ||
Mouse   735 WEALCAYQAEPNSSLVAQREENAPKNRSLAVLTYDHSRILLKSQNSHGSSDYINASPIMDHD-PR 798

  Fly  1397 E--FIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLI 1459
            .  :|.|||||.:|..:||:|.|||....|||||...|.|..:|..||| |..:..|...:|.|:
Mouse   799 NPAYIATQGPLPATVADFWQMVWESGCAVIVMLTPLSENGVRQCHHYWP-DEGSNLYHVYEVNLV 862

  Fly  1460 IDTHYHDWSISEFMVS-------RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTD 1517
            .:   |.| ..:|:|.       :..|:|.:..|||.:|.|.|||...:||:.|.|.........
Mouse   863 SE---HIW-CQDFLVRSFYLKNLQTNETRTVTQFHFLSWYDQGVPSSTRSLLDFRRKVNKCYRGR 923

  Fly  1518 MRPIIVHCSAGVGRSGTFIALDRILQHIHK-SDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCL 1581
            ..|||||||.|.|||||::.:|.:|..:.| :..:||...:..:|.:|..||||::|:   ...|
Mouse   924 SCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQF---EFAL 985

  Fly  1582 LAVLE 1586
            .||.|
Mouse   986 TAVAE 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	20/86 (23%)
		fn3	247..328	CDD:394996	18/78 (23%)
		FN3	319..>749	CDD:442628	79/443 (18%)
		fn3	708..796	CDD:394996	18/87 (21%)
		fn3	902..978	CDD:394996	11/88 (13%)
		fn3	1013..1092	CDD:394996	16/78 (21%)
		PTP_tm	1127..1247	CDD:465889	15/119 (13%)
		R3-PTPc	1358..1579	CDD:350396	88/230 (38%)
Ptprn2	NP_035345.2	Involved in localization to secretory granules, interaction with CPE. /evidence=ECO:0000269|PubMed:21210912	1..407		124/683 (18%)
		RESP18	<80..>126	CDD:464394	12/94 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..296		9/36 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	308..359		14/78 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..459		14/118 (12%)
		Receptor_IA-2	495..583	CDD:463293	30/191 (16%)
		Tyrosine-based internalization motif. /evidence=ECO:0000250|UniProtKB:Q63475	652..661		1/8 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..705		12/41 (29%)
		R-PTP-N2	713..995	CDD:350458	101/287 (35%)
		Leucine-based sorting signal. /evidence=ECO:0000305|PubMed:16262730	990..996		1/1 (100%)